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Fzd4
Gene Detail
Symbol

Name
ID
Fzd4
frizzled homolog 4 (Drosophila)
MGI:108520
Synonyms
Fz4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
49.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:89404366-89410110 bp, + strand
From Ensembl annotation of GRCm38

  5745 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FZD4
Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd4

Human
homologs
FZD4, frizzled class receptor 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8322
neXtProt AC: NX_Q9ULV1

Human Synonyms: CD344, EVR1, FEVR, Fz4, Fz-4, FZD4S, FzE4, GPCR, hFz4

Human Chr (Location): 11q14.2; chr11:86945675-86955398 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FZD4

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display abnormalities in hearing, locomotion, retinal morphology, and degeneration of the cerebellum.
 
Human Diseases Modeled in Mice Using Fzd4 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Fzd4 interacts with 290 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process blood vessel development, canonical Wnt signaling pathway, ...
Component cell-cell junction, cell surface, ...
Function cytokine binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (360)    Tissues (205)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 290
RT-PCR 65
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FZD4 ; Xenbase fzd4 ; ZFIN fzd4    NEW 
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(28) Primer pair(8) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000049791 (Evidence)
Entrez Gene 14366 (Evidence)
UniGene 86755
DFCI TC1581042
DoTS DT.529597, DT.486707
NIA Mouse Gene Index U042832
Consensus CDS Project CCDS21441.1
International Mouse Phenotyping Consortium Status Fzd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049791 Ensembl Gene Model | MGI Sequence Detail 5745 C57BL/6J ±  kb
transcript ENSMUST00000058755 Ensembl | MGI Sequence Detail 3685 Not Applicable 
polypeptide ENSMUSP00000049852 Ensembl | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026551 Frizzled-4
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000001454 frizzled-4
References
(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:215763 Zhou Y, et al., Canonical WNT signaling components in vascular development and barrier formation. J Clin Invest. 2014 Sep 2;124(9):3825-46
All references(84)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-37564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory