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Fzd4
Gene Detail
Symbol

Name
ID
Fzd4
frizzled homolog 4 (Drosophila)
MGI:108520
Synonyms
Fz4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
49.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:89404366-89410110 bp, + strand
From Ensembl annotation of GRCm38

  5745 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd4

Human
homologs
Human Homolog FZD4, frizzled class receptor 4
NCBI Gene ID 8322
neXtProt AC  NX_Q9ULV1
Human Synonyms  CD344, EVR1, FEVR, Fz4, Fz-4, FZD4S, FzE4, GPCR, hFz4
Human Chr (Location)  11q14.2; chr11:86945675-86955398 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FZD4
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display abnormalities in hearing, locomotion, retinal morphology, and degeneration of the cerebellum.
 
Human Diseases Modeled Using Mouse Fzd4 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Fzd4 interacts with 291 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process blood vessel development, canonical Wnt signaling pathway, ...
Component cell-cell junction, cell surface, ...
Function cytokine binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (360)    Tissues (205)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 290
RT-PCR 65
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(28) Primer pair(8) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000049791 (Evidence)
Entrez Gene14366 (Evidence)
UniGene86755
DFCITC1581042
DoTSDT.529597, DT.486707
NIA Mouse Gene IndexU042832
Consensus CDS ProjectCCDS21441.1
International Mouse Knockout Project StatusFzd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049791 Ensembl Gene Model | MGI Sequence Detail 5745 C57BL/6J ±  kb
transcript ENSMUST00000058755 Ensembl | MGI Sequence Detail 3685 Not Applicable 
polypeptide ENSMUSP00000049852 Ensembl | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026551 Frizzled-4
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000001454 frizzled-4
References
(Earliest) J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
(Latest) J:202907 Grigoryan T, et al., Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
All references(85)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-37564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory