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Fzd4 Gene Detail
Summary
  • Symbol
    Fzd4
  • Name
    frizzled class receptor 4
  • Synonyms
    Fz4
  • Feature Type
    protein coding gene
  • IDs
    MGI:108520
    NCBI Gene: 14366
  • Gene Overview
    MyGene.info: FZD4
Location & Maps
more
  • Sequence Map
    Chr7:89404355-89413134 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8780 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 49.32 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FZD4, frizzled class receptor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD4, frizzled class receptor 4
    Orthology source: HomoloGene
  • Synonyms
    CD344, EVR1, FEVR, Fz4, Fz-4, FZD4S, FzE4, GPCR, hFz4
  • Links
    NCBI Gene ID: 8322
    neXtProt AC: NX_Q9ULV1

  • Chr Location
    11q14.2; chr11:86945675-86955398 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Fzd4 mouse models; 1 with human FZD4 associations

Human Disease Mouse Models
       Exudative Vitreoretinopathy 1; EVR1   OMIM: 133780 View 1 model
       Norrie Disease; ND   OMIM: 310600 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    3
  • Targeted
    6
  • Genomic Mutations
    4 involving Fzd4
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene display abnormalities in hearing, locomotion, retinal morphology, and degeneration of the cerebellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059643 VEGA Gene Model | MGI Sequence Detail 8780 C57BL/6J ±  kb
transcript OTTMUST00000146243 VEGA | MGI Sequence Detail 6720 Not Applicable  
polypeptide OTTMUSP00000076168 VEGA | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 1
    cDNA 28
    Primer pair 8
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-37564
References
more
  • Summaries
    All 86
    Developmental Gene Expression 39
    Diseases 2
    Gene Ontology 18
    Phenotypes 39
  • Earliest
    J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
  • Latest
    J:221356 Snowball J, et al., Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015 May 15;401(2):264-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory