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Fzd4 Gene Detail
Summary
  • Symbol
    Fzd4
  • Name
    frizzled class receptor 4
  • Synonyms
    Fz4
  • Feature Type
    protein coding gene
  • IDs
    MGI:108520
    NCBI Gene: 14366
  • Gene Overview
    MyGene.info: FZD4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:89404355-89413134 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8780 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 49.32 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FZD4, frizzled class receptor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD4, frizzled class receptor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD344, EVR1, FEVR, Fz4, Fz-4, FZD4S, FzE4, GPCR, hFz4
  • Links
    NCBI Gene ID: 8322
    neXtProt AC: NX_Q9ULV1
    UniProt: Q9ULV1

  • Chr Location
    11q14.2; chr11:86945675-86955398 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Fzd4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in hearing, locomotion, retinal morphology, and degeneration of the cerebellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059643 VEGA Gene Model | MGI Sequence Detail 8780 C57BL/6J ±  kb
    transcript OTTMUST00000146243 VEGA | MGI Sequence Detail 6720 Not Applicable  
    polypeptide OTTMUSP00000076168 VEGA | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      63 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 1
      cDNA 29
      Primer pair 9
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-37564
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 21
      Phenotypes 44
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:253067 Sigal M, et al., Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory