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Ccl12 Gene Detail
Summary
  • Symbol
    Ccl12
  • Name
    chemokine (C-C motif) ligand 12
  • Synonyms
    MCP-5, Scya12
  • Feature Type
    protein coding gene
  • IDs
    MGI:108224
    NCBI Gene: 20293
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr11:82101845-82103399 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 49.90 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108224
protein coding gene Chr11:82101845-82103400 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018824
protein coding gene Chr11:83350697-83352252 (+)
A/J MGP_AJ_G0018791
protein coding gene Chr11:80144908-80146463 (+)
AKR/J MGP_AKRJ_G0018761
protein coding gene Chr11:82543483-82545038 (+)
BALB/cJ MGP_BALBcJ_G0018764
protein coding gene Chr11:80538146-80539701 (+)
C3H/HeJ MGP_C3HHeJ_G0018578
protein coding gene Chr11:82591559-82593114 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019216
protein coding gene Chr11:85848941-85850496 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016850
protein coding gene Chr11:77115545-77117108 (+)
CAST/EiJ MGP_CASTEiJ_G0018133
protein coding gene Chr11:83149999-83151555 (+)
CBA/J MGP_CBAJ_G0018549
protein coding gene Chr11:89617217-89618772 (+)
DBA/2J MGP_DBA2J_G0018657
protein coding gene Chr11:79707070-79708625 (+)
FVB/NJ MGP_FVBNJ_G0018646
protein coding gene Chr11:79253342-79254897 (+)
LP/J MGP_LPJ_G0018727
protein coding gene Chr11:83878094-83879649 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018673
protein coding gene Chr11:89796565-89798120 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019256
protein coding gene Chr11:82808239-82809794 (+)
PWK/PhJ MGP_PWKPhJ_G0017903
protein coding gene Chr11:80533742-80535298 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017694
protein coding gene Chr11:82422673-82424232 (+)
WSB/EiJ MGP_WSBEiJ_G0018185
protein coding gene Chr11:82685458-82687014 (+)



Homology
more
  • Human Ortholog
    CCL2, C-C motif chemokine ligand 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCL2, C-C motif chemokine ligand 2
    Orthology source: HomoloGene
  • Synonyms
    GDCF-2, HC11, HSMCR30, MCAF, MCP1, MCP-1, SCYA2, SMC-CF
  • Links
    NCBI Gene ID: 6347
    neXtProt AC: NX_P13500
    UniProt: P13500

  • Chr Location
    17q12; chr17:34255277-34257203 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    14 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ccl12
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele are viable, fertile and developmentally normal with no apparent alterations in monocyte homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20293 NCBI Gene Model | MGI Sequence Detail 1555 C57BL/6J ±  kb
transcript NM_011331 RefSeq | MGI Sequence Detail 536 C57BL/6  
polypeptide Q62401 UniProt | EBI | MGI Sequence Detail 104 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 3
    cDNA 19
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37263
References
more
  • Summaries
    All 50
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:239310 Rhee C, et al., ARID3A is required for mammalian placenta development. Dev Biol. 2017 Feb 15;422(2):83-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory