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Ccl12 Gene Detail
Summary
  • Symbol
    Ccl12
  • Name
    chemokine (C-C motif) ligand 12
  • Synonyms
    MCP-5, Scya12
  • Feature Type
    protein coding gene
  • IDs
    MGI:108224
    NCBI Gene: 20293
Location & Maps
more
  • Sequence Map
    Chr11:82101845-82103400 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1556 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 49.90 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CCL2, C-C motif chemokine ligand 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCL2, C-C motif chemokine ligand 2
    Orthology source: HomoloGene
  • Synonyms
    GDCF-2, HC11, HSMCR30, MCAF, MCP1, MCP-1, SCYA2, SMC-CF
  • Links
    NCBI Gene ID: 6347
    neXtProt AC: NX_P13500

  • Chr Location
    17q11.2-q12; chr17:34255277-34257203 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    14 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ccl12
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele are viable, fertile and developmentally normal with no apparent alterations in monocyte homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000861 VEGA Gene Model | MGI Sequence Detail 1556 C57BL/6J ±  kb
transcript OTTMUST00000001671 VEGA | MGI Sequence Detail 537 Not Applicable  
polypeptide OTTMUSP00000000792 VEGA | MGI Sequence Detail 104 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006165 C-C motif chemokine 12
  • InterPro Domains
    IPR000827 CC chemokine, conserved site
    IPR001811 Chemokine interleukin-8-like domain
Molecular
Reagents
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  • All nucleic 22
    Genomic 3
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-37263
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:36581 Jia GQ, et al., Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996 Nov 1;184(5):1939-51
  • Latest
    J:209816 Severa M, et al., The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J Immunol. 2014 Mar 1;192(5):2291-304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory