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Ccl12
Gene Detail
Symbol

Name
ID
Ccl12
chemokine (C-C motif) ligand 12
MGI:108224
Synonyms
MCP-5, Scya12
Feature Type
protein coding gene
Genetic Map
Chromosome 11
49.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:82101845-82103400 bp, + strand
From VEGA annotation of GRCm38

  1556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2245  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CCL2
Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl12

Human
homologs
CCL2, chemokine (C-C motif) ligand 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6347
neXtProt AC: NX_P13500

Human Synonyms: GDCF-2, HC11, HSMCR30, MCAF, MCP1, MCP-1, SCYA2, SMC-CF

Human Chr (Location): 17q11.2-q12; chr17:34255277-34257203 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human CCL2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Ccl12 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele are viable, fertile and developmentally normal with no apparent alterations in monocyte homeostasis.
 
Interactions
Ccl12 interacts with 22 markers (Mir10b, Mir18b, Mir130a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process angiogenesis, astrocyte cell migration, ...
Component extracellular region, extracellular space, ...
Function CCR2 chemokine receptor binding, chemokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (41)    Tissues (28)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000861 (Evidence)
Ensembl Gene Model ENSMUSG00000035352 (Evidence)
Entrez Gene 20293 (Evidence)
UniGene 867
DFCI TC1585562
DoTS DT.486425
NIA Mouse Gene Index U013064
Consensus CDS Project CCDS36247.1
International Mouse Phenotyping Consortium Status Ccl12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000861 VEGA Gene Model | MGI Sequence Detail 1556 C57BL/6J ±  kb
transcript OTTMUST00000001671 VEGA | MGI Sequence Detail 537 Not Applicable 
polypeptide OTTMUSP00000000792 VEGA | MGI Sequence Detail 104 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000827 CC chemokine, conserved site
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000006165 C-C motif chemokine 12
References
(Earliest) J:36581 Jia GQ, et al., Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996 Nov 1;184(5):1939-51
(Latest) J:209816 Severa M, et al., The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J Immunol. 2014 Mar 1;192(5):2291-304
All references(38)
Other
accession IDs
MGD-MRK-37263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory