Sfrp2 MGI Mouse Gene Detail - MGI:108078 - secreted frizzled-related protein 2

Sfrp2 Gene Detail

Symbol

Sfrp2
Name

secreted frizzled-related protein 2
Synonyms

Sdf5

Feature Type

protein coding gene
IDs

MGI:108078
NCBI Gene: 20319
Gene Overview

MyGene.info: SFRP2

Sequence Map

Chr3:83766321-83774316 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

7996 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 37.37 cM
Mapping Data

2 experiments

Human Ortholog

SFRP2, secreted frizzled related protein 2

Vertebrate Orthologs

9

Human Ortholog

SFRP2, secreted frizzled related protein 2
Orthology source: HomoloGene, HGNC
Synonyms

FRP-2, SARP1, SDF-5
Links

HGNC:10777

NCBI Gene ID: 6423

neXtProt AC: NX_Q96HF1

UniProt: Q96HF1
Chr Location

4q31.3; chr4:153780590-153789076 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56438
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SFRP2
Protein SuperFamily

secreted frizzled-related protein
Gene Tree

Sfrp2

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References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 6 alleles in 9 genetic backgrounds
21 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

2
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Sfrp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a null allele exhibit background-sensitive syndactyly.

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All GO Annotations

87
GO References

30

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

573
Tissues

372
cDNA Data

56
Literature Summary

119

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SFRP2

Xenbase sfrp2

ZFIN sfrp2

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Sfrp2 interacts with 192 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

25
RefSeq

4
UniProt

3
CCDS

CCDS17434.1
UniGene

19155

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021261	VEGA Gene Model \| MGI Sequence Detail	7996	C57BL/6J	± kb
transcript	OTTMUST00000050381	VEGA \| MGI Sequence Detail	2003	Not Applicable
polypeptide	OTTMUSP00000023506	VEGA \| MGI Sequence Detail	295	Not Applicable

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SNPs within 2kb

26 from dbSNP Build 142

RFLP

1

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UniProt

3 Sequences
Protein Ontology

PR:000014745 secreted frizzled-related protein 2

(term hierarchy)
InterPro Domains

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR026558 Secreted frizzled-related protein 2

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

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All nucleic 75

cDNA 59

Primer pair 7

Other 9

Microarray probesets 3

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MGD-MRK-37115, MGI:2139824

Summaries

All 176

Developmental Gene Expression 119

Diseases 1

Gene Ontology 30

Phenotypes 32
Earliest

J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
Latest

J:240026 Minegishi K, et al., A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017 Mar 13;40(5):439-452.e4

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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