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Sfrp2
Gene Detail
 Symbol
Name
ID
Sfrp2
secreted frizzled-related protein 2
MGI:108078
Synonyms Sdf5
Feature Type protein coding gene
Genetic Map
Chromosome 3
37.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:83766321-83774316 bp, + strand
From VEGA annotation of GRCm38

  7996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: secreted frizzled-related protein
Gene Tree: Sfrp2

Human
homologs
Human Homolog SFRP2, secreted frizzled-related protein 2
NCBI Gene ID 6423
neXtProt AC  NX_Q96HF1
Human Synonyms  FRP-2, SARP1, SDF-5
Human Chr (Location)  4q31.3; chr4:153780590-153789076 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Chemically induced (ENU)(2) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit background-sensitive syndactyly.
 
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process anterior/posterior pattern specification, apoptotic process, ...
Component cytoplasm, extracellular region, ...
Function endopeptidase activator activity, metalloenzyme activator activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (99 records)
Data Summary: Results (377)    Tissues (281)    Images (136)
Theiler Stages: 2, 3, 5, 8, 9, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 324
Northern blot 4
RT-PCR 49
cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(69) cDNA(55) Primer pair(6) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021261 (Evidence)
Ensembl Gene ModelENSMUSG00000027996 (Evidence)
Entrez Gene20319 (Evidence)
UniGene19155
DFCITC1575182
DoTSDT.101160312, DT.111066781, DT.55100405, DT.91401783
NIA Mouse Gene IndexU003371
Consensus CDS ProjectCCDS17434.1
International Mouse Knockout Project StatusSfrp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021261 VEGA Gene Model | MGI Sequence Detail 7996 C57BL/6J ±  kb
transcript OTTMUST00000050381 VEGA | MGI Sequence Detail 2003 Not Applicable 
polypeptide OTTMUSP00000023506 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR026558 Secreted frizzled-related protein 2
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000014745 secreted frizzled-related protein 2
References (Earliest) J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(152)
Other
accession IDs
MGD-MRK-37115, MGI:2139824

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory