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Sfrp2
Gene Detail
Symbol

Name
ID
Sfrp2
secreted frizzled-related protein 2
MGI:108078
Synonyms
Sdf5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
37.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:83766321-83774316 bp, + strand
From VEGA annotation of GRCm38

  7996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SFRP2
Protein SuperFamily: secreted frizzled-related protein
Gene Tree: Sfrp2

Human
homologs
SFRP2, secreted frizzled-related protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6423
neXtProt AC: NX_Q96HF1

Human Synonyms: FRP-2, SARP1, SDF-5

Human Chr (Location): 4q31.3; chr4:153780590-153789076 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit background-sensitive syndactyly.
 
Interactions
Sfrp2 interacts with 192 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (106 records)
Data Summary: Results (377)    Tissues (282)    Images (136)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 324
Northern blot 4
RT-PCR 49
cDNA source data(53)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SFRP2 ; Xenbase sfrp2 ; ZFIN sfrp2    NEW 
Molecular
reagents
All nucleic(69) cDNA(55) Primer pair(6) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021261 (Evidence)
Ensembl Gene Model ENSMUSG00000027996 (Evidence)
Entrez Gene 20319 (Evidence)
UniGene 19155
DFCI TC1575182
DoTS DT.55100405, DT.111066781, DT.101160312, DT.91401783
NIA Mouse Gene Index U003371
Consensus CDS Project CCDS17434.1
International Mouse Phenotyping Consortium Status Sfrp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021261 VEGA Gene Model | MGI Sequence Detail 7996 C57BL/6J ±  kb
transcript OTTMUST00000050381 VEGA | MGI Sequence Detail 2003 Not Applicable 
polypeptide OTTMUSP00000023506 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR026558 Secreted frizzled-related protein 2
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000014745 secreted frizzled-related protein 2
References
(Earliest) J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
(Latest) J:220152 Marcos S, et al., Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms. J Neurosci. 2015 Mar 18;35(11):4729-40
All references(159)
Other
accession IDs
MGD-MRK-37115, MGI:2139824

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory