Sfrp2
Gene Detail

Symbol

Name
ID

Sfrp2
secreted frizzled-related protein 2
MGI:108078

Synonyms

Sdf5

Feature Type

protein coding gene

Genetic Map

Chromosome 3
37.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:83766321-83774316 bp, + strand From VEGA annotation of GRCm38   7996 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: secreted frizzled-related protein
Gene Tree: Sfrp2

Human
homologs

Human Homolog		SFRP2, secreted frizzled-related protein 2
NCBI Gene ID		6423
neXtProt AC		NX_Q96HF1
Human Synonyms		FRP-2, SARP1, SDF-5
Human Chr (Location)		4q31.3; chr4:153780590-153789076 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Chemically induced (ENU)(2) Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit background-sensitive syndactyly.

 

Interactions

Sfrp2 interacts with 192 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (82 annotations)

Process	anterior/posterior pattern specification, apoptotic process, ...
Component	extracellular region, extracellular space
Function	endopeptidase activator activity, metalloenzyme activator activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (105 records)

Data Summary: Results (377)    Tissues (282)    Images (136)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	324
Northern blot	4
RT-PCR	49

cDNA source data(53)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(69) cDNA(55) Primer pair(6) Other(8)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000021261 (Evidence)
Ensembl Gene Model	ENSMUSG00000027996 (Evidence)
Entrez Gene	20319 (Evidence)
UniGene	19155
DFCI	TC1575182
DoTS	DT.101160312, DT.111066781, DT.91401783, DT.55100405
NIA Mouse Gene Index	U003371
Consensus CDS Project	CCDS17434.1
International Mouse Knockout Project Status	Sfrp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021261	VEGA Gene Model | MGI Sequence Detail	7996	C57BL/6J
transcript	OTTMUST00000050381	VEGA | MGI Sequence Detail	2003	Not Applicable
polypeptide	OTTMUSP00000023506	VEGA | MGI Sequence Detail	295	Not Applicable

All sequences(31) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR020067	Frizzled domain
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR001134	Netrin domain
InterPro	IPR018933	Netrin module, non-TIMP type
InterPro	IPR026558	Secreted frizzled-related protein 2
InterPro	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology	PR:000014745	secreted frizzled-related protein 2

References

(Earliest) J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
(Latest) J:216214 Raspopovic J, et al., Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients. Science. 2014 Aug 1;345(6196):566-70
All references(158)

Other
accession IDs

MGD-MRK-37115, MGI:2139824