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Sfrp2 Gene Detail
Summary
  • Symbol
    Sfrp2
  • Name
    secreted frizzled-related protein 2
  • Synonyms
    Sdf5
  • Feature Type
    protein coding gene
  • IDs
    MGI:108078
    NCBI Gene: 20319
  • Gene Overview
    MyGene.info: SFRP2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:83766321-83774316 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108078
protein coding gene Chr3:83766158-83774316 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027336
protein coding gene Chr3:83626522-83634509 (+)
A/J MGP_AJ_G0027300
protein coding gene Chr3:80876512-80884511 (+)
AKR/J MGP_AKRJ_G0027266
protein coding gene Chr3:82778716-82786704 (+)
BALB/cJ MGP_BALBcJ_G0027309
protein coding gene Chr3:80946123-80954119 (+)
C3H/HeJ MGP_C3HHeJ_G0027053
protein coding gene Chr3:83075449-83083441 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027755
protein coding gene Chr3:86768232-86776227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025108
protein coding gene Chr3:76532809-76540599 (+)
CAST/EiJ MGP_CASTEiJ_G0026500
protein coding gene Chr3:83262784-83270771 (+)
CBA/J MGP_CBAJ_G0027028
protein coding gene Chr3:89681592-89689591 (+)
DBA/2J MGP_DBA2J_G0027164
protein coding gene Chr3:80397972-80405969 (+)
FVB/NJ MGP_FVBNJ_G0027132
protein coding gene Chr3:78677139-78685142 (+)
LP/J MGP_LPJ_G0027272
protein coding gene Chr3:84594756-84602748 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027151
protein coding gene Chr3:96068535-96076531 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027813
protein coding gene Chr3:82576994-82584962 (+)
PWK/PhJ MGP_PWKPhJ_G0026234
protein coding gene Chr3:80158157-80166165 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026050
protein coding gene Chr3:81755794-81763841 (+)
WSB/EiJ MGP_WSBEiJ_G0026578
protein coding gene Chr3:82923665-82931657 (+)



Homology
more
  • Human Ortholog
    SFRP2, secreted frizzled related protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SFRP2, secreted frizzled related protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRP-2, SARP1, SDF-5
  • Links
    NCBI Gene ID: 6423
    neXtProt AC: NX_Q96HF1
    UniProt: Q96HF1

  • Chr Location
    4q31.3; chr4:153780590-153789076 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 9 genetic backgrounds
    21 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit background-sensitive syndactyly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027996 Ensembl Gene Model | MGI Sequence Detail 7996 C57BL/6J ±  kb
    transcript ENSMUST00000029625 Ensembl | MGI Sequence Detail 2003 Not Applicable  
    polypeptide ENSMUSP00000029625 Ensembl | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 60
      Primer pair 7
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37115, MGI:2139824
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 127
      Diseases 1
      Gene Ontology 32
      Phenotypes 32
    • Earliest
      J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
    • Latest
      J:266242 Desmaris E, et al., DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. J Neurosci. 2018 Oct 17;38(42):9105-9121

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory