Sfrp2 MGI Mouse Gene Detail - MGI:108078 - secreted frizzled-related protein 2

Symbol

Sfrp2
Name

secreted frizzled-related protein 2
Synonyms

Sdf5

Feature Type

protein coding gene
IDs

MGI:108078
NCBI Gene: 20319
Gene Overview

MyGene.info: SFRP2
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:83766321-83774316 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 37.37 cM
Mapping Data

2 experiments

SNPs within 2kb

26 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108078	protein coding gene	Chr3:83766158-83774316 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027336	protein coding gene	Chr3:83626522-83634509 (+)
A/J	MGP_AJ_G0027300	protein coding gene	Chr3:80876512-80884511 (+)
AKR/J	MGP_AKRJ_G0027266	protein coding gene	Chr3:82778716-82786704 (+)
BALB/cJ	MGP_BALBcJ_G0027309	protein coding gene	Chr3:80946123-80954119 (+)
C3H/HeJ	MGP_C3HHeJ_G0027053	protein coding gene	Chr3:83075449-83083441 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027755	protein coding gene	Chr3:86768232-86776227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025108	protein coding gene	Chr3:76532809-76540599 (+)
CAST/EiJ	MGP_CASTEiJ_G0026500	protein coding gene	Chr3:83262784-83270771 (+)
CBA/J	MGP_CBAJ_G0027028	protein coding gene	Chr3:89681592-89689591 (+)
DBA/2J	MGP_DBA2J_G0027164	protein coding gene	Chr3:80397972-80405969 (+)
FVB/NJ	MGP_FVBNJ_G0027132	protein coding gene	Chr3:78677139-78685142 (+)
LP/J	MGP_LPJ_G0027272	protein coding gene	Chr3:84594756-84602748 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027151	protein coding gene	Chr3:96068535-96076531 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027813	protein coding gene	Chr3:82576994-82584962 (+)
PWK/PhJ	MGP_PWKPhJ_G0026234	protein coding gene	Chr3:80158157-80166165 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026050	protein coding gene	Chr3:81755794-81763841 (+)
WSB/EiJ	MGP_WSBEiJ_G0026578	protein coding gene	Chr3:82923665-82931657 (+)

Human Ortholog

SFRP2, secreted frizzled related protein 2

Vertebrate Orthologs

9

Human Ortholog

SFRP2, secreted frizzled related protein 2
Orthology source: HomoloGene, HGNC
Synonyms

FRP-2, SARP1, SDF-5
Links

HGNC:10777

NCBI Gene ID: 6423

neXtProt AC: NX_Q96HF1

UniProt: Q96HF1
Chr Location

4q31.3; chr4:153780590-153789076 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56438
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SFRP2
Protein SuperFamily

secreted frizzled-related protein
Gene Tree

Sfrp2

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References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 6 alleles in 9 genetic backgrounds
21 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

2
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Sfrp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit background-sensitive syndactyly.

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All GO Annotations

89
GO References

30

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

582
Tissues

379
cDNA Data

57
Literature Summary

130

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SFRP2

Xenbase sfrp2

ZFIN sfrp2

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Sfrp2 interacts with 192 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

38
RefSeq

4
UniProt

3
CCDS

CCDS17434.1
UniGene

19155

Ensembl

ENSMUSG00000027996 (Evidence)
NCBI Gene

20319

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027996	Ensembl Gene Model \| MGI Sequence Detail	7996	C57BL/6J	± kb
transcript	ENSMUST00000029625	Ensembl \| MGI Sequence Detail	2003	Not Applicable
polypeptide	ENSMUSP00000029625	Ensembl \| MGI Sequence Detail	295	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014745 secreted frizzled-related protein 2

(term hierarchy)
InterPro Domains

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR026558 Secreted frizzled-related protein 2

IPR041764 SFRP2, cysteine-rich domain

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

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All nucleic 77

cDNA 60

Primer pair 7

Other 10

Microarray probesets 3

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MGD-MRK-37115, MGI:2139824

Summaries

All 190

Developmental Gene Expression 130

Diseases 1

Gene Ontology 30

Phenotypes 32
Earliest

J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
Latest

J:277244 LaHaye S, et al., Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24;12(6)

TSS for Sfrp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29718	Chr3:83766173-83766187 (+)	-141 bp
Tssr29719	Chr3:83766300-83766331 (+)	-5 bp
Tssr29720	Chr3:83766602-83766613 (+)	287 bp
Tssr29721	Chr3:83766616-83766621 (+)	298 bp
Tssr29722	Chr3:83766628-83766639 (+)	313 bp
Tssr29723	Chr3:83766661-83766672 (+)	346 bp
Tssr29724	Chr3:83766979-83766990 (+)	664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14