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Sfrp2 Gene Detail
Summary
  • Symbol
    Sfrp2
  • Name
    secreted frizzled-related protein 2
  • Synonyms
    Sdf5
  • Feature Type
    protein coding gene
  • IDs
    MGI:108078
    NCBI Gene: 20319
  • Gene Overview
    MyGene.info: SFRP2
Location & Maps
more
  • Sequence Map
    Chr3:83766321-83774316 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7996 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.37 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SFRP2, secreted frizzled related protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SFRP2, secreted frizzled related protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRP-2, SARP1, SDF-5
  • Links
    NCBI Gene ID: 6423
    neXtProt AC: NX_Q96HF1

  • Chr Location
    4q31.3; chr4:153780590-153789076 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 6 alleles in 9 genetic backgrounds
    21 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Sfrp2
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a null allele exhibit background-sensitive syndactyly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    87
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    525
  • Tissues
    361
  • cDNA Data
    54
  • Literature Summary
    113
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021261 VEGA Gene Model | MGI Sequence Detail 7996 C57BL/6J ±  kb
transcript OTTMUST00000050381 VEGA | MGI Sequence Detail 2003 Not Applicable  
polypeptide OTTMUSP00000023506 VEGA | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    26 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014745 secreted frizzled-related protein 2
  • InterPro Domains
    IPR020067 Frizzled domain
    IPR015526 Frizzled/secreted frizzled-related protein
    IPR001134 Netrin domain
    IPR018933 Netrin module, non-TIMP type
    IPR026558 Secreted frizzled-related protein 2
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Molecular
Reagents
less
  • All nucleic 72
    cDNA 57
    Primer pair 6
    Other 9

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37115, MGI:2139824
References
more
  • Summaries
    All 166
    Developmental Gene Expression 113
    Gene Ontology 30
    Phenotypes 28
  • Earliest
    J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
  • Latest
    J:231601 de Melo J, et al., Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory