Sfrp2 MGI Mouse Gene Detail - MGI:108078 - secreted frizzled-related protein 2

Symbol

Sfrp2
Name

secreted frizzled-related protein 2
Synonyms

Sdf5

Feature Type

protein coding gene
IDs

MGI:108078
NCBI Gene: 20319
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:83673628-83681621 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 37.37 cM
Mapping Data

2 experiments

SNPs within 2kb

348 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108078	protein coding gene	Chr3:83673628-83681623 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027336	protein coding gene	Chr3:83626522-83634509 (+)
A/J	MGP_AJ_G0027300	protein coding gene	Chr3:80876512-80884511 (+)
AKR/J	MGP_AKRJ_G0027266	protein coding gene	Chr3:82778716-82786704 (+)
BALB/cJ	MGP_BALBcJ_G0027309	protein coding gene	Chr3:80946123-80954119 (+)
C3H/HeJ	MGP_C3HHeJ_G0027053	protein coding gene	Chr3:83075449-83083441 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027755	protein coding gene	Chr3:86768232-86776227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025108	protein coding gene	Chr3:76532809-76540599 (+)
CAST/EiJ	MGP_CASTEiJ_G0026500	protein coding gene	Chr3:83262784-83270771 (+)
CBA/J	MGP_CBAJ_G0027028	protein coding gene	Chr3:89681592-89689591 (+)
DBA/2J	MGP_DBA2J_G0027164	protein coding gene	Chr3:80397972-80405969 (+)
FVB/NJ	MGP_FVBNJ_G0027132	protein coding gene	Chr3:78677139-78685142 (+)
LP/J	MGP_LPJ_G0027272	protein coding gene	Chr3:84594756-84602748 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027151	protein coding gene	Chr3:96068535-96076531 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027813	protein coding gene	Chr3:82576994-82584962 (+)
PWK/PhJ	MGP_PWKPhJ_G0026234	protein coding gene	Chr3:80158157-80166165 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026050	protein coding gene	Chr3:81755794-81763841 (+)
WSB/EiJ	MGP_WSBEiJ_G0026578	protein coding gene	Chr3:82923665-82931657 (+)

Human Ortholog

SFRP2, secreted frizzled related protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFRP2, secreted frizzled related protein 2
Synonyms

FRP-2, SARP1, SDF-5
Links

HGNC:10777

NCBI Gene ID: 6423

UniProt: Q96HF1
Chr Location

4q31.3; chr4:153780591-153789083 (-) GRCh38

MGI Vertebrate Homology

Sfrp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFRP2
Gene Tree

Sfrp2

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References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 6 alleles in 10 genetic backgrounds
23 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

1
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Sfrp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit background-sensitive syndactyly.

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All GO Annotations

121
GO References

32

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1445
Tissues

443
cDNA Data

61
Literature Summary

162

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SFRP2

Xenbase sfrp2

ZFIN sfrp2

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS17434.1

Ensembl

ENSMUSG00000027996 (Evidence)
NCBI Gene

20319

			Length	Strain/Species	Flank
genomic	20319	NCBI Gene Model \| MGI Sequence Detail	7994	C57BL/6J	± kb
transcript	NM_009144	RefSeq \| MGI Sequence Detail	2001	Not Specified
polypeptide	P97299	UniProt \| EBI \| MGI Sequence Detail	295	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014745 secreted frizzled-related protein 2

(term hierarchy)
InterPro Domains

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR041764 SFRP2, cysteine-rich domain

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

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All nucleic 96

cDNA 65

Primer pair 16

Other 15

Microarray probesets 3

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MGD-MRK-37115, MGI:2139824

Summaries

All 234

Developmental Gene Expression 162

Diseases 1

Gene Ontology 32

Phenotypes 39
Earliest

J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
Latest

J:368673 Mulvaney JF, et al., Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea. Cells. 2025 Jun 12;14(12)

TSS for Sfrp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29718	Chr3:83673480-83673494 (+)	-141 bp
Tssr29719	Chr3:83673607-83673638 (+)	-5 bp
Tssr29720	Chr3:83673909-83673920 (+)	287 bp
Tssr29721	Chr3:83673923-83673928 (+)	298 bp
Tssr29722	Chr3:83673935-83673946 (+)	313 bp
Tssr29723	Chr3:83673968-83673979 (+)	346 bp
Tssr29724	Chr3:83674286-83674297 (+)	664 bp
Tssr29725	Chr3:83681154-83681167 (+)	7,533 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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