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Nkx3-2
Gene Detail
 Symbol
Name
ID
Nkx3-2
NK3 homeobox 2
MGI:108015
Synonyms Bapx1, Nkx-3.2
Feature Type protein coding gene
Genetic Map
Chromosome 5
22.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:41761483-41764496 bp, - strand
From VEGA annotation of GRCm38

  3014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68168  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Nkx3-2

Human
homologs
Human Homolog NKX3-2, NK3 homeobox 2
NCBI Gene ID 579
neXtProt AC  NX_P78367
Human Synonyms  BAPX1, NKX3.2, NKX3B, SMMD
Human Chr (Location)  4p16.3; chr4:13540830-13544490 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NKX3-2
Alleles
and
phenotypes
All alleles(14) : Targeted(14)
 
Homozygous null mutants are perinatal lethal, lack a spleen, and display skeletal dysplasia of the vertebral column and cranium.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process determination of left/right symmetry, digestive system development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (289)    Tissues (200)    Images (101)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 267
In situ reporter (knock in) 17
Northern blot 2
RT-PCR 3
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(11) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036567 (Evidence)
Ensembl Gene ModelENSMUSG00000049691 (Evidence)
Entrez Gene12020 (Evidence)
UniGene2530
DFCITC1590178
DoTSDT.87058833
NIA Mouse Gene IndexU026147
Consensus CDS ProjectCCDS19259.1
International Mouse Knockout Project StatusNkx3-2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036567 VEGA Gene Model | MGI Sequence Detail 3014 C57BL/6J ±  kb
transcript OTTMUST00000093782 VEGA | MGI Sequence Detail 1713 Not Applicable 
polypeptide OTTMUSP00000052105 VEGA | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011249 homeobox protein Nkx-3.2
References (Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:199664 Huang H, et al., Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14;288(24):17589-96
All references(82)
Other
accession IDs
MGD-MRK-37050

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory