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Nkx3-2
Gene Detail
Symbol

Name
ID
Nkx3-2
NK3 homeobox 2
MGI:108015
Synonyms
Bapx1, Nkx-3.2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
22.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:41761483-41764501 bp, - strand
From VEGA annotation of GRCm38

  3019 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68168  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NKX3-2
Gene Tree: Nkx3-2

Human
homologs
NKX3-2, NK3 homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 579
neXtProt AC: NX_P78367

Human Synonyms: BAPX1, NKX3.2, NKX3B, SMMD

Human Chr (Location): 4p16.3; chr4:13540830-13544490 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NKX3-2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Radiation induced(2) Targeted(14)
Genomic Mutations involving Nkx3-2 (3)
Incidental mutations (data from CvDC )
 
Homozygous null mutants are perinatal lethal, lack a spleen, and display skeletal dysplasia of the vertebral column and cranium.
 
Mutations Annotated to Human Diseases (3)    Phenotype Images(9)
Interactions
Nkx3-2 interacts with 6 markers (Mir214, Mir761, Mir876, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (42 records)
Data Summary: Results (289)    Tissues (200)    Images (101)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 267
In situ reporter (knock in) 17
Northern blot 2
RT-PCR 3
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN nkx3.2    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(11) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036567 (Evidence)
Ensembl Gene Model ENSMUSG00000049691 (Evidence)
Entrez Gene 12020 (Evidence)
UniGene 2530
DFCI TC1590178
DoTS DT.87058833
NIA Mouse Gene Index U026147
Consensus CDS Project CCDS19259.1
International Mouse Phenotyping Consortium Status Nkx3-2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036567 VEGA Gene Model | MGI Sequence Detail 3019 C57BL/6J ±  kb
transcript OTTMUST00000093782 VEGA | MGI Sequence Detail 1718 Not Applicable 
polypeptide OTTMUSP00000052105 VEGA | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011249 homeobox protein Nkx-3.2
References
(Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:222691 Kitazawa T, et al., Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids. Nat Commun. 2015;6:6853
All references(84)
Other
accession IDs
MGD-MRK-37050

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory