Nkx3-2
Gene Detail

Symbol Name ID

Nkx3-2 NK3 homeobox 2 MGI:108015

Synonyms

Bapx1, Nkx-3.2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

22.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:41761483-41764496 bp, - strand From VEGA annotation of GRCm38   3014 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68168  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Nkx3-2

Human homologs

Human Homolog		NKX3-2, NK3 homeobox 2
NCBI Gene ID		579
neXtProt AC		NX_P78367
Human Synonyms		BAPX1, NKX3.2, NKX3B, SMMD
Human Chr (Location)		4p16.3; chr4:13542454-13546114 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NKX3-2

Alleles and phenotypes

All alleles(14) : Targeted(14)
 

Homozygous null mutants are perinatal lethal, lack a spleen, and display skeletal dysplasia of the vertebral column and cranium.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	determination of left/right symmetry, digestive system development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (285)    Tissues (199)    Images (97)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	263
In situ reporter (knock in)	17
Northern blot	2
RT-PCR	3

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(3) cDNA(11) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036567 (Evidence)
Ensembl Gene Model	ENSMUSG00000049691 (Evidence)
Entrez Gene	12020 (Evidence)
UniGene	2530
DFCI	TC1590178
DoTS	DT.87058833
NIA Mouse Gene Index	U026147
Consensus CDS Project	CCDS19259.1
International Mouse Knockout Project Status	Nkx3-2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036567	VEGA Gene Model | MGI Sequence Detail	3014	C57BL/6J
transcript	OTTMUST00000093782	VEGA | MGI Sequence Detail	1713	Not Applicable
polypeptide	OTTMUSP00000052105	VEGA | MGI Sequence Detail	333	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000011249	homeobox protein Nkx-3.2

References

(Earliest) J:37599 Wightman PJ, et al., The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997 Sep;8(9):700-1
(Latest) J:190564 Tavares AL, et al., Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol. 2012 Nov 1;371(1):47-56
All references(80)

Other accession IDs

MGD-MRK-37050