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Adam8 Gene Detail
Summary
  • Symbol
    Adam8
  • Name
    a disintegrin and metallopeptidase domain 8
  • Synonyms
    CD156, CD156a, E430039A18Rik, MS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107825
    NCBI Gene: 11501
  • Gene Overview
    MyGene.info: ADAM8
Location & Maps
more
  • Sequence Map
    Chr7:139978932-139992562 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13631 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 84.96 cM, cytoband F3-F5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAM8, ADAM metallopeptidase domain 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADAM8, ADAM metallopeptidase domain 8
    Orthology source: HomoloGene
  • Synonyms
    CD156, CD156a, MS2
  • Links
    NCBI Gene ID: 101
    neXtProt AC: NX_P78325

  • Chr Location
    10q26.3; chr10:133262416-133276903 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    1 involving Adam8
  • Incidental Mutations
Homozygous mutant mice do not exhibit any morphological or pathological abnormalities. Mice homozygous for a different knock-out allele exhibit reduced osteoclast differentiation and calvarial fibrosis in response to TNF-alpha treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021266 VEGA Gene Model | MGI Sequence Detail 13631 C57BL/6J ±  kb
transcript OTTMUST00000050398 VEGA | MGI Sequence Detail 3117 Not Applicable  
polypeptide OTTMUSP00000023515 VEGA | MGI Sequence Detail 826 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    46 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 56
    Genomic 2
    cDNA 54

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36402, MGI:2443633
References
more
  • Summaries
    All 58
    Developmental Gene Expression 4
    Gene Ontology 17
    Phenotypes 21
  • Earliest
    J:11115 Yoshida S, et al., Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage. Int Immunol. 1990;2(6):585-91
  • Latest
    J:217682 Nishimura D, et al., Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration. Mech Dev. 2015 Feb;135:58-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory