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Adam8 Gene Detail
Summary
  • Symbol
    Adam8
  • Name
    a disintegrin and metallopeptidase domain 8
  • Synonyms
    CD156, CD156a, E430039A18Rik, MS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107825
    NCBI Gene: 11501
  • Gene Overview
    MyGene.info: ADAM8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:139978932-139992562 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13631 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 84.96 cM, cytoband F3-F5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADAM8, ADAM metallopeptidase domain 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADAM8, ADAM metallopeptidase domain 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD156, CD156a, MS2
  • Links
    NCBI Gene ID: 101
    neXtProt AC: NX_P78325
    UniProt: P78325

  • Chr Location
    10q26.3; chr10:133262416-133276903 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice do not exhibit any morphological or pathological abnormalities. Mice homozygous for a different knock-out allele exhibit reduced osteoclast differentiation and calvarial fibrosis in response to TNF-alpha treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021266 VEGA Gene Model | MGI Sequence Detail 13631 C57BL/6J ±  kb
    transcript OTTMUST00000050398 VEGA | MGI Sequence Detail 3117 Not Applicable  
    polypeptide OTTMUSP00000023515 VEGA | MGI Sequence Detail 826 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      46 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 2
      cDNA 54
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36402, MGI:2443633
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 5
      Gene Ontology 17
      Phenotypes 23
    • Earliest
      J:11115 Yoshida S, et al., Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage. Int Immunol. 1990;2(6):585-91
    • Latest
      J:256626 Theodorou K, et al., Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Sci Rep. 2017 Sep 15;7(1):11670

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory