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Adam8
Gene Detail
Symbol

Name
ID
Adam8
a disintegrin and metallopeptidase domain 8
MGI:107825
Synonyms
CD156, CD156a, E430039A18Rik, MS2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
84.96 cM, cytoband F3-F5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:139978932-139992562 bp, - strand
From VEGA annotation of GRCm38

  13631 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Gene Tree: Adam8

Human
homologs
Human Homolog ADAM8, ADAM metallopeptidase domain 8
NCBI Gene ID 101
neXtProt AC  NX_P78325
Human Synonyms  CD156, CD156a, MS2
Human Chr (Location)  10q26.3; chr10:133262416-133276903 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice do not exhibit any morphological or pathological abnormalities. Mice homozygous for a different knock-out allele exhibit reduced osteoclast differentiation and calvarial fibrosis in response to TNF-alpha treatment.
 
Interactions
Adam8 interacts with 73 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (4 records)
Data Summary: Results (47)    Tissues (31)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
In situ reporter (knock in) 8
Western blot 3
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(2) cDNA(54)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021266 (Evidence)
Ensembl Gene ModelENSMUSG00000025473 (Evidence)
Entrez Gene11501 (Evidence)
UniGene15969
DFCITC1605319, TC1573387, TC1713528
NIA Mouse Gene IndexU029415
EC3.4.24.-
Consensus CDS ProjectCCDS21959.1, CCDS72064.1
International Mouse Knockout Project StatusAdam8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021266 VEGA Gene Model | MGI Sequence Detail 13631 C57BL/6J ±  kb
transcript OTTMUST00000050398 VEGA | MGI Sequence Detail 3117 Not Applicable 
polypeptide OTTMUSP00000023515 VEGA | MGI Sequence Detail 826 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(9) UniProt(23)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000001280 disintegrin and metalloproteinase domain-containing protein 8
References
(Earliest) J:11115 Yoshida S, et al., Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage. Int Immunol. 1990;2(6):585-91
(Latest) J:214181 Guaiquil VH, et al., A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease. Invest Ophthalmol Vis Sci. 2013 Aug;54(8):5294-302
All references(59)
Other
accession IDs
MGD-MRK-36402, MGI:2443633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory