Adam8 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adam8
a disintegrin and metallopeptidase domain 8
MGI:107825

12 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adam8^tm1.1Mdz/Adam8^tm1.1Mdz DBA/1LacJ-Adam8^tm1.1Mdz	decreased susceptibility to induced arthritis	J:155243
Adam8^tm1.1Mdz/Adam8^tm1.1Mdz DBA/1LacJ-Adam8^tm1.1Mdz	normal immune system phenotype	J:155243
Adam8^tm1.1Rood/Adam8^tm1.1Rood involves: 129/Sv * C57BL/6 * FVB/N	abnormal osteoclast differentiation	J:172936
	abnormal response/metabolism to endogenous compounds	J:172936
	normal skeleton phenotype	J:172936
Adam8^tm1Bbl/Adam8^tm1Bbl involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:95366
Tg(Acp5-Adam8)#Rood/0 involves: BALB/c * C57BL/6	abnormal osteoclast differentiation	J:172936
	abnormal osteoclast morphology	J:172936
	abnormal trabecular bone morphology	J:172936
	decreased bone mineral density	J:172936
	decreased bone volume	J:172936
	increased bone resorption	J:172936
	increased osteoclast cell number	J:172936

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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