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Dctn1
Gene Detail
Symbol

Name
ID
Dctn1
dynactin 1
MGI:107745
Synonyms
Glued, p150, p150glued
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:83165920-83200117 bp, + strand
From VEGA annotation of GRCm38

  34198 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3011  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DCTN1
Gene Tree: Dctn1

Human
homologs
DCTN1, dynactin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1639
neXtProt AC: NX_Q14203

Human Synonyms: DAP-150, DP-150, P135

Human Chr (Location): 2p13; chr2:74361154-74392087 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human DCTN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(16) Spontaneous(1) Targeted(4) Transgenic(1)
Genomic Mutations involving Dctn1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit embryonic lethality and developmental arrest at E7.5 associated with increased apoptosis.
 
Interactions
Dctn1 interacts with 67 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process melanosome transport, microtubule-based transport, ...
Component cell, cell leading edge, ...
Function dynein binding, motor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (11)    Tissues (6)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 11
cDNA source data(205)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dctn1 ; ZFIN dctn1a    NEW 
Molecular
reagents
All nucleic(210) Genomic(3) cDNA(207)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024506 (Evidence)
Ensembl Gene Model ENSMUSG00000031865 (Evidence)
Entrez Gene 13191 (Evidence)
UniGene 6919
DFCI TC1572689, TC1607218, TC1633717
DoTS DT.101153840, DT.101257806, DT.103568647, DT.110475323, DT.40157415, DT.87072552
NIA Mouse Gene Index U007080, U077623
Consensus CDS Project CCDS39532.1, CCDS57432.1, CCDS57433.1
International Mouse Phenotyping Consortium Status Dctn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024506 VEGA Gene Model | MGI Sequence Detail 34198 C57BL/6J ±  kb
transcript OTTMUST00000060251 VEGA | MGI Sequence Detail 4292 Not Applicable 
polypeptide OTTMUSP00000029381 VEGA | MGI Sequence Detail 1281 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(30) UniProt(10)
Polymorphisms
RFLP(2) : SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000938 CAP Gly-rich domain
InterPro IPR027663 Dynactin subunit 1
InterPro IPR022157 Dynein associated protein
Protein Ontology PR:000006323 dynactin subunit 1
References
(Earliest) J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
(Latest) J:207807 Kodani A, et al., Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013 Feb 20;32(4):597-607
All references(56)
Other
accession IDs
MGD-MRK-36321, MGI:2144338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory