Dctn1
Gene Detail

Symbol Name ID

Dctn1 dynactin 1 MGI:107745

Synonyms

Glued, p150, p150

Feature Type

protein coding gene

Genetic Map

Chromosome 6

35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:83165920-83200117 bp, + strand From VEGA annotation of GRCm38   34198 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Dctn1 ± 2 cM)

Gene Tree: Dctn1

Human ortholog

DCTN1 dynactin 1 NCBI Gene ID 1639
Human Synonyms: DAP-150, DP-150, P135
Human Chr2:74588281-74619214 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human DCTN1 (3)

Alleles and phenotypes

All alleles(20) : Targeted(4) Gene trapped(16)
 

Mice homozygous for a null allele exhibit embryonic lethality and developmental arrest at E7.5 associated with increased apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	transport
Component	cell leading edge, centrosome, ...
Function	motor activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (11)    Tissues (6)    Images (1)
Theiler Stages: 17, 21, 24, 26, 28

Assay Type	Results
Western blot	11

cDNA source data(205)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(210) Genomic(3) cDNA(207)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024506 (Evidence)
Ensembl Gene Model	ENSMUSG00000031865 (Evidence)
Entrez Gene	13191 (Evidence)
UniGene	6919
DFCI	TC1572689, TC1607218, TC1633717
DoTS	DT.101153840, DT.101257806, DT.103568647, DT.110475323, DT.40157415, DT.87072552
NIA Mouse Gene Index	U007080, U077623
Consensus CDS Project	CCDS39532.1, CCDS57432.1, CCDS57433.1
International Mouse Knockout Project Status	Dctn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024506	VEGA Gene Model | MGI Sequence Detail	34198	C57BL/6J
transcript	OTTMUST00000060251	VEGA | MGI Sequence Detail	4292	Not Applicable
polypeptide	OTTMUSP00000029381	VEGA | MGI Sequence Detail	1281	Not Applicable

All sequences(89) RefSeq(6) UniProt(10)

Polymorphisms

RFLP(2) : SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000938	CAP Gly-rich domain
InterPro	IPR022157	Dynein associated protein
Protein Ontology	PR:000006323	dynactin subunit 1

References

(Earliest) J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
(Latest) J:188383 Moughamian AJ, et al., Dynactin is required for transport initiation from the distal axon. Neuron. 2012 Apr 26;74(2):331-43
All references(50)

Other accession IDs

MGD-MRK-36321, MGI:2144338