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Dctn1
Gene Detail
 Symbol
Name
ID
Dctn1
dynactin 1
MGI:107745
Synonyms Glued, p150, p150glued
Feature Type protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:83165920-83200117 bp, + strand
From VEGA annotation of GRCm38

  34198 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3011  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dctn1

Human
homologs
Human Homolog DCTN1, dynactin 1
NCBI Gene ID 1639
neXtProt AC  NX_Q14203
Human Synonyms  DAP-150, DP-150, P135
Human Chr (Location)  2p13; chr2:74361154-74392087 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human DCTN1
Alleles
and
phenotypes
All alleles(20) : Gene trapped(16) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality and developmental arrest at E7.5 associated with increased apoptosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process melanosome transport, microtubule-based transport, ...
Component cell, cell leading edge, ...
Function dynein binding, motor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (11)    Tissues (6)    Images (1)
Theiler Stages: 17, 21, 24, 26, 28
Assay TypeResults
Western blot 11
cDNA source data(205)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(210) Genomic(3) cDNA(207)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024506 (Evidence)
Ensembl Gene ModelENSMUSG00000031865 (Evidence)
Entrez Gene13191 (Evidence)
UniGene6919
DFCITC1572689, TC1607218, TC1633717
DoTSDT.101153840, DT.101257806, DT.103568647, DT.110475323, DT.40157415, DT.87072552
NIA Mouse Gene IndexU007080, U077623
Consensus CDS ProjectCCDS39532.1, CCDS57432.1, CCDS57433.1
International Mouse Knockout Project StatusDctn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024506 VEGA Gene Model | MGI Sequence Detail 34198 C57BL/6J ±  kb
transcript OTTMUST00000060251 VEGA | MGI Sequence Detail 4292 Not Applicable 
polypeptide OTTMUSP00000029381 VEGA | MGI Sequence Detail 1281 Not Applicable 

For the selected sequences
All sequences(113) RefSeq(30) UniProt(10)
Polymorphisms RFLP(2) : SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000938 CAP Gly-rich domain
InterPro IPR022157 Dynein associated protein
Protein Ontology PR:000006323 dynactin subunit 1
References (Earliest) J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
(Latest) J:207807 Kodani A, et al., Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013 Feb 20;32(4):597-607
All references(56)
Other
accession IDs
MGD-MRK-36321, MGI:2144338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory