Analysis Tools
behavior/neurological
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• in the tail suspension test, 6- and 9-month-old males and 15-month-old females show longer periods of immobility indicating depression-like behavior
• however, mice show no deficit in exploratory behavior in the open-field indicating no apathy-like behavior
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• in the beam walking test, females at 9 months, but not 6 months, show an increase in traversing time of beam
• however, male mice show no difference in traversing the beam and mice of both sexes and all ages show no difference in latency to fall on the rotarod
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bradykinesia
(
J:375720
)
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• 9-month-old females take longer to perform a turn (t-turn) or a descent (t-descent) in the pole test and 15-month-old females show a longer t-descent, indicative of parkinsonian bradykinesia
• however, 9-month-old males only show a tendency of extended t-turn
• heavier body weight of males compared to females may suggest that this heavier weight prevents detection of motor dysfunction in males as correlation between body weight and reduction in motor performance are detected
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nervous system
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• males, but not females, exhibit reduced tyrosine hydroxylase signal intensity in cell bodies in the substantia nigra pars compacta and neurites in the substantia nigra reticulum, indicating a reduction of catecholaminergic, including dopaminergic neurons in the substantia nigra
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growth/size/body
| N |
• mice do not exhibit weight loss
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muscle
| N |
• mice show no differences in the traction-meter test indicating normal muscle strength and suggesting no obvious muscle atrophy
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Perry syndrome | DOID:0060486 |
OMIM:168605 |
J:375720 | |
