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Irgm1 Gene Detail
Summary
  • Symbol
    Irgm1
  • Name
    immunity-related GTPase family M member 1
  • Synonyms
    Ifi1, Iigp3, Irgm, LRG-47
  • Feature Type
    protein coding gene
  • IDs
    MGI:107567
    NCBI Gene: 15944
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:48865245-48871454 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 28.84 cM, cytoband B1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107567
protein coding gene Chr11:48861968-48871683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018207
protein coding gene Chr11:47893178-47902866 (-)
A/J MGP_AJ_G0018178
protein coding gene Chr11:45985939-45995684 (-)
AKR/J MGP_AKRJ_G0018144
protein coding gene Chr11:47425432-47435137 (-)
BALB/cJ MGP_BALBcJ_G0018147
protein coding gene Chr11:46201582-46211240 (-)
C3H/HeJ MGP_C3HHeJ_G0017961
protein coding gene Chr11:47426895-47436520 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018601
protein coding gene Chr11:49334616-49344765 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016256
protein coding gene Chr11:43849980-43860111 (-)
CAST/EiJ MGP_CASTEiJ_G0017524
protein coding gene Chr11:47589295-47601112 (-)
CBA/J MGP_CBAJ_G0017933
protein coding gene Chr11:51598995-51609455 (-)
DBA/2J MGP_DBA2J_G0018043
protein coding gene Chr11:45841706-45851351 (-)
FVB/NJ MGP_FVBNJ_G0018037
protein coding gene Chr11:45433611-45443239 (-)
LP/J MGP_LPJ_G0018115
protein coding gene Chr11:48140802-48150551 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018061
protein coding gene Chr11:53049545-53060088 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018640
protein coding gene Chr11:47582563-47592262 (-)
PWK/PhJ MGP_PWKPhJ_G0017304
protein coding gene Chr11:46235132-46245289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017097
protein coding gene Chr11:47309458-47319615 (-)
WSB/EiJ MGP_WSBEiJ_G0017574
protein coding gene Chr11:47212991-47222658 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
In the absence of infection, mice show no overt phenotype. Resistance to protozoan parasitic infection and bacterial infection is impaired in homozygous mutant mice, whereas resistance to viral infection is normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15944 NCBI Gene Model | MGI Sequence Detail 6210 C57BL/6J ±  kb
    transcript NM_008326 RefSeq | MGI Sequence Detail 2321 C57BL/6  
    polypeptide Q60766 UniProt | EBI | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 65
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36139
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 32
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257085 Rogala AR, et al., Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. Dis Model Mech. 2018 Feb 7;11(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory