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Irgm1
Gene Detail
Symbol

Name
ID
Irgm1
immunity-related GTPase family M member 1
MGI:107567
Synonyms
Ifi1, Iigp3, Irgm, LRG-47
Feature Type
protein coding gene
Genetic Map
Chromosome 11
28.84 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:48861968-48871683 bp, - strand
From VEGA annotation of GRCm38

  9716 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134089  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Irgm1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
In the absence of infection, mice show no overt phenotype. Resistance to protozoan parasitic infection and bacterial infection is impaired in homozygous mutant mice, whereas resistance to viral infection is normal.
 
Interactions
Irgm1 interacts with 108 markers (Mir7b, Mir15b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process autophagy, defense response, ...
Component cell projection, cytoplasmic vesicle, ...
Function GTP binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (92)    Tissues (45)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 92
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) cDNA(64) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005518 (Evidence)
Ensembl Gene ModelENSMUSG00000046879 (Evidence)
Entrez Gene15944 (Evidence)
UniGene29938
DFCITC1578819
DoTSDT.50316949, DT.94405348
NIA Mouse Gene IndexU032710
EC3.6.5.-
Consensus CDS ProjectCCDS24588.1
International Mouse Knockout Project StatusIrgm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005518 VEGA Gene Model | MGI Sequence Detail 9716 C57BL/6J ±  kb
transcript OTTMUST00000012269 VEGA | MGI Sequence Detail 2259 Not Applicable 
polypeptide OTTMUSP00000005664 VEGA | MGI Sequence Detail 409 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007743 Interferon-inducible GTPase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000033996 immunity-related GTPase family M protein 1
References
(Earliest) J:29047 Sorace JM, et al., Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family. J Leukoc Biol. 1995 Oct;58(4):477-84
(Latest) J:208845 Pilla DM, et al., Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51
All references(57)
Other
accession IDs
MGD-MRK-36139

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory