Irgm1
Gene Detail

Symbol Name ID

Irgm1 immunity-related GTPase family M member 1 MGI:107567

Synonyms

Ifi1, Iigp3, Irgm, LRG-47

Feature Type

protein coding gene

Genetic Map

Chromosome 11

28.84 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:48861968-48871683 bp, - strand From VEGA annotation of GRCm38   9716 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:78363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 3 dog

Gene Tree: Irgm1

Human homologs

Human Homolog		IRGM, immunity-related GTPase family, M
NCBI Gene ID		345611
neXtProt AC		NX_A1A4Y4
Human Synonyms		IFI1, IRGM1, LRG47, LRG-47
Human Chr (Location)		5q33.1; chr5:150226085-150228231 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IRGM

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)
 

In the absence of infection, mice show no overt phenotype. Resistance to protozoan parasitic infection and bacterial infection is impaired in homozygous mutant mice, whereas resistance to viral infection is normal.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	autophagy, defense response, ...
Component	cell projection, cytoplasmic vesicle, ...
Function	GTP binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (92)    Tissues (45)    Images (2)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	92

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(64) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005518 (Evidence)
Ensembl Gene Model	ENSMUSG00000046879 (Evidence)
Entrez Gene	15944 (Evidence)
UniGene	29938
DFCI	TC1578819
DoTS	DT.50316949, DT.94405348
NIA Mouse Gene Index	U032710
EC	3.6.5.-
Consensus CDS Project	CCDS24588.1
International Mouse Knockout Project Status	Irgm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005518	VEGA Gene Model | MGI Sequence Detail	9716	C57BL/6J
transcript	OTTMUST00000012269	VEGA | MGI Sequence Detail	2259	Not Applicable
polypeptide	OTTMUSP00000005664	VEGA | MGI Sequence Detail	409	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007743	Interferon-inducible GTPase
Protein Ontology	PR:000033996	immunity-related GTPase family M protein 1

References

(Earliest) J:29047 Sorace JM, et al., Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family. J Leukoc Biol. 1995 Oct;58(4):477-84
(Latest) J:190883 Tischler AD, et al., Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation To Resist Host Immunity. Infect Immun. 2013 Jan;81(1):317-28
All references(53)

Other accession IDs

MGD-MRK-36139