Sequence Detail

ID/Version

Q60766 Q3TJ73 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Immunity-related GTPase family M protein 1 {ECO:0000305}; EC=3.6.5.- {ECO:0000269|PubMed:19620982};AltName: Full=Interferon-inducible GTPase 3;AltName: Full=Interferon-inducible protein 1 {ECO:0000303|PubMed:17911638};AltName: Full=L

Provider

SWISS-PROT

Sequence

Polypeptide 409 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irgm1	immunity-related GTPase family M member 1	92	98	2	8

Sequence references in MGI

J:29047 Sorace JM, et al., Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family. J Leukoc Biol. 1995 Oct;58(4):477-84
J:87364 Feng CG, et al., Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol. 2004 Jan 15;172(2):1163-8
J:87535 Collazo CM, et al., Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med. 2001 Jul 16;194(2):181-8
J:92658 Martens S, et al., Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis. J Immunol. 2004 Aug 15;173(4):2594-606
J:99144 Butcher BA, et al., p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Infect Immun. 2005 Jun;73(6):3278-86
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122278 Santiago HC, et al., Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. J Immunol. 2005 Dec 15;175(12):8165-72
J:142840 Feng CG, et al., The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol. 2008 Nov;9(11):1279-87
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:149806 Feng CG, et al., The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell. 2008 Jan 10;2(1):83-9
J:151541 Tiwari S, et al., Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol. 2009 Aug;10(8):907-17
J:153019 Bafica A, et al., The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. J Immunol. 2007 Oct 15;179(8):5514-22
J:153857 Henry SC, et al., Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). J Immunol. 2007 Nov 15;179(10):6963-72
J:157117 Henry SC, et al., Regulation of macrophage motility by Irgm1. J Leukoc Biol. 2010 Feb;87(2):333-43
J:157238 Zhao YO, et al., Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. PLoS One. 2010;5(1):e8648
J:176619 Traver MK, et al., Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. J Biol Chem. 2011 Sep 2;286(35):30471-80
J:176943 King KY, et al., Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood. 2011 Aug 11;118(6):1525-33
J:241380 Schmidt EA, et al., Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. J Biol Chem. 2017 Mar 17;292(11):4651-4662
J:243244 Xu Y, et al., Irgm1 is required for the inflammatory function of M1 macrophage in early experimental autoimmune encephalomyelitis. J Leukoc Biol. 2017 Feb;101(2):507-517
J:271759 Mehto S, et al., The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. Mol Cell. 2019 Feb 7;73(3):429-445.e7
J:292423 Taylor GA, et al., Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium. PLoS Pathog. 2020 May;16(5):e1008553
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298776 Jena KK, et al., Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response. EMBO Rep. 2020 Sep 3;21(9):e50051
J:305209 Rai P, et al., IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol. 2021 Mar;22(3):312-321
J:317923 Haldar AK, et al., IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. PLoS Pathog. 2013;9(6):e1003414
J:318620 Fang S, et al., Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development. Atherosclerosis. 2016 Aug;251:282-290
J:328106 Fan Y, et al., Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis. Cell Death Differ. 2022 Sep;29(9):1673-1688
J:329066 He S, et al., Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke. Autophagy. 2012 Nov;8(11):1621-7
J:332981 Maric-Biresev J, et al., Loss of the interferon-gamma-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection. BMC Biol. 2016 Apr 20;14:33
J:332983 Nath P, et al., Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. EMBO Rep. 2021 Nov 4;22(11):e52948
J:332984 Henry SC, et al., Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission. PLoS One. 2014;9(4):e95021