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Kcnj11
Gene Detail
Symbol

Name
ID
Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
MGI:107501
Synonyms
Kir6.2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:46098725-46099897 bp, - strand
From Ensembl annotation of GRCm38

  1173 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNJ11
Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj11

Human
homologs
KCNJ11, potassium channel, inwardly rectifying subfamily J, member 11
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3767
neXtProt AC: NX_Q14654

Human Synonyms: BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3

Human Chr (Location): 11p15.1; chr11:17364824-17389331 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human KCNJ11

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impaired insulin secretion, mild glucose intolerance, reduced glucagon secretion in response to hypoglycemia, hypoxia-induced seizure susceptibility, and stress-induced arrhythmia and sudden death.
 
Human Diseases Modeled in Mice Using Kcnj11 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Kcnj11 interacts with 11 markers (Mir194-1, Mir194-2, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process glucose metabolic process, ion transport, ...
Component ATP-sensitive potassium channel complex, axolemma, ...
Function ankyrin binding, ATP-activated inward rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (31)    Tissues (8)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 5
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(5) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000096146 (Evidence)
Entrez Gene 16514 (Evidence)
DFCI TC1582596
DoTS DT.99849525, DT.55282641
NIA Mouse Gene Index U028550
Consensus CDS Project CCDS21274.1
International Mouse Phenotyping Consortium Status Kcnj11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000096146 Ensembl Gene Model | MGI Sequence Detail 1173 C57BL/6J ±  kb
transcript ENSMUST00000180081 Ensembl | MGI Sequence Detail 1173 Not Applicable 
polypeptide ENSMUSP00000136002 Ensembl | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003279 Potassium channel, inwardly rectifying, Kir6.2
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000001980 ATP-sensitive inward rectifier potassium channel 11
References
(Earliest) J:30315 Sakura H, et al., Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett. 1995 Dec 27;377(3):338-44
(Latest) J:218743 Lutas A, et al., Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47
All references(126)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-36069, MGI:2142042, MGI:2142236

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory