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Kcnj11
Gene Detail
 Symbol
Name
ID
Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
MGI:107501
Synonyms Kir6.2
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:46098725-46099897 bp, - strand
From Ensembl annotation of GRCm38

  1173 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj11

Human
homologs
Human Homolog KCNJ11, potassium inwardly-rectifying channel, subfamily J, member 11
NCBI Gene ID 3767
neXtProt AC  NX_Q14654
Human Synonyms  BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Human Chr (Location)  11p15.1; chr11:17385237-17389331 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human KCNJ11
Alleles
and
phenotypes
All alleles(6) : Chemically induced (ENU)(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impaired insulin secretion, mild glucose intolerance, reduced glucagon secretion in response to hypoglycemia, hypoxia-induced seizure susceptibility, and stress-induced arrhythmia and sudden death.
 
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process glucose metabolic process, ion transport, ...
Component ATP-sensitive potassium channel complex, axolemma, ...
Function ankyrin binding, ATP-activated inward rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (31)    Tissues (7)    Images (21)
Theiler Stages: 22, 23, 25, 28
Assay TypeResults
RNA in situ 26
RT-PCR 5
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(5) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000096146 (Evidence)
Entrez Gene16514 (Evidence)
DFCITC1582596
DoTSDT.55282641, DT.99849525
NIA Mouse Gene IndexU028550
Consensus CDS ProjectCCDS21274.1
International Mouse Knockout Project StatusKcnj11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000096146 Ensembl Gene Model | MGI Sequence Detail 1173 C57BL/6J ±  kb
transcript ENSMUST00000180081 Ensembl | MGI Sequence Detail 1173 Not Applicable 
polypeptide ENSMUSP00000136002 Ensembl | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003279 Potassium channel, inwardly rectifying, Kir6.2
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000001980 ATP-sensitive inward rectifier potassium channel 11
References (Earliest) J:30315 Sakura H, et al., Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett. 1995 Dec 27;377(3):338-44
(Latest) J:203488 Li JB, et al., Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels. J Biol Chem. 2013 Aug 9;288(32):23038-49
All references(122)
Other
accession IDs
MGD-MRK-36069, MGI:2142042, MGI:2142236

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory