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Kcnj11 Gene Detail
Summary
  • Symbol
    Kcnj11
  • Name
    potassium inwardly rectifying channel, subfamily J, member 11
  • Synonyms
    Kir6.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107501
    NCBI Gene: 16514
  • Gene Overview
    MyGene.info: KCNJ11
Location & Maps
more
  • Sequence Map
    Chr7:46098725-46099897 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1173 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.66 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KCNJ11, potassium voltage-gated channel subfamily J member 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ11, potassium voltage-gated channel subfamily J member 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3
  • Links
    NCBI Gene ID: 3767
    neXtProt AC: NX_Q14654

  • Chr Location
    11p15.1; chr11:17364824-17389331 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Kcnj11 mouse models; 5 with human KCNJ11 associations

Human Disease Mouse Models
       Diabetes Mellitus, Permanent Neonatal; PNDM   OMIM: 606176 View 3 models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853
Diabetes Mellitus, Transient Neonatal, 3   OMIM: 610582
Hyperinsulinemic Hypoglycemia, Familial, 2; HHF2   OMIM: 601820
Maturity-Onset Diabetes of the Young, Type 13; MODY13   OMIM: 616329
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 5 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    1 images
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    2
  • Targeted
    8
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit impaired insulin secretion, mild glucose intolerance, reduced glucagon secretion in response to hypoglycemia, hypoxia-induced seizure susceptibility, and stress-induced arrhythmia and sudden death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000096146 Ensembl Gene Model | MGI Sequence Detail 1173 C57BL/6J ±  kb
transcript ENSMUST00000180081 Ensembl | MGI Sequence Detail 1173 Not Applicable  
polypeptide ENSMUSP00000136002 Ensembl | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001980 ATP-sensitive inward rectifier potassium channel 11
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003279 Potassium channel, inwardly rectifying, Kir6.2
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 9
    Genomic 3
    cDNA 5
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36069, MGI:2142042, MGI:2142236
References
more
  • Summaries
    All 127
    Developmental Gene Expression 9
    Diseases 5
    Gene Ontology 10
    Phenotypes 83
  • Earliest
    J:30315 Sakura H, et al., Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett. 1995 Dec 27;377(3):338-44
  • Latest
    J:228179 Marquard J, et al., Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nat Med. 2015 Apr;21(4):363-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory