Kcnj11
Gene Detail

Symbol Name ID

Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 MGI:107501

Synonyms

Kir6.2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:46098725-46099897 bp, - strand From Ensembl annotation of GRCm38   1173 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj11

Human homologs

Human Homolog		KCNJ11, potassium inwardly-rectifying channel, subfamily J, member 11
NCBI Gene ID		3767
neXtProt AC		NX_Q14654
Human Synonyms		BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Human Chr (Location)		11p15.1; chr11:17406795-17410878 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human KCNJ11

Alleles and phenotypes

All alleles(6) : Targeted(4) Chemically induced(2)
 

Homozygotes for a targeted null mutation exhibit impaired insulin secretion, mild glucose intolerance, reduced glucagon secretion in response to hypoglycemia, hypoxia-induced seizure susceptibility, and stress-induced arrhythmia and sudden death.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	glucose metabolic process, ion transport, ...
Component	ATP-sensitive potassium channel complex, endoplasmic reticulum, ...
Function	ankyrin binding, ATP-activated inward rectifier potassium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (31)    Tissues (7)    Images (21)
Theiler Stages: 22, 23, 25, 28

Assay Type	Results
RNA in situ	26
RT-PCR	5

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(3) cDNA(12) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000096146 (Evidence)
Entrez Gene	16514 (Evidence)
UniGene	333863
DFCI	TC1582596
DoTS	DT.55282641, DT.99849525
NIA Mouse Gene Index	U028550
Consensus CDS Project	CCDS21274.1
International Mouse Knockout Project Status	Kcnj11

Sequences

Length	Strain/Species
genomic	ENSMUSG00000096146	Ensembl Gene Model | MGI Sequence Detail	1173	C57BL/6J
transcript	ENSMUST00000180081	Ensembl | MGI Sequence Detail	1173	Not Applicable
polypeptide	ENSMUSP00000136002	Ensembl | MGI Sequence Detail	390	Not Applicable

All sequences(25) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR016449	Potassium channel, inwardly rectifying, Kir
InterPro	IPR003279	Potassium channel, inwardly rectifying, Kir6.2
InterPro	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology	PR:000001980	ATP-sensitive inward rectifier potassium channel 11

References

(Earliest) J:30315 Sakura H, et al., Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle. FEBS Lett. 1995 Dec 27;377(3):338-44
(Latest) J:192283 Zhou Y, et al., Enhanced MK-801-induced locomotion in Kir6.2 knockout mice. Neurosci Res. 2012 Dec;74(3-4):195-9
All references(118)

Other accession IDs

MGD-MRK-36069, MGI:2142042, MGI:2142236