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Gdnf
Gene Detail
Symbol

Name
ID
Gdnf
glial cell line derived neurotrophic factor
MGI:107430
Synonyms
glial cell line-derived neurotrophic factor
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:7811011-7837575 bp, + strand
From Ensembl annotation of GRCm38

  26565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GDNF
Protein SuperFamily: glial cell line-derived neurotrophic factor
Gene Tree: Gdnf

Human
homologs
GDNF, glial cell derived neurotrophic factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2668
neXtProt AC: NX_P39905

Human Synonyms: ATF1, ATF2, HFB1-GDNF, HSCR3

Human Chr (Location): 5p13.1-p12; chr5:37812677-37839680 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human GDNF

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(9) Transposon induced(1)
Genomic Mutations involving Gdnf (1)
 
Homozygous inactivation of this gene leads to lack of ureteric bud induction, bilateral renal agenesis, absence of enteric neurons, and neonatal death. Heterozygotes show renal phenotypes ranging from two small kidneys, often with abnormal shapes and cortical cysts, to unilateral renal agenesis.
 
Human Diseases Modeled in Mice Using Gdnf (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Gdnf interacts with 287 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (152 records)
Data Summary: Results (367)    Tissues (176)    Images (90)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 183
In situ reporter (knock in) 1
RT-PCR 183
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GDNF ZFIN gdnfa    NEW 
Molecular
reagents
All nucleic(31) Genomic(4) cDNA(17) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022144 (Evidence)
Entrez Gene 14573 (Evidence)
UniGene 4679
DFCI TC1666746, TC1591077, TC1679564
DoTS DT.91446648, DT.481635
NIA Mouse Gene Index U149303, U016047
Consensus CDS Project CCDS27371.1
International Mouse Phenotyping Consortium Status Gdnf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022144 Ensembl Gene Model | MGI Sequence Detail 26565 C57BL/6J ±  kb
transcript ENSMUST00000022744 Ensembl | MGI Sequence Detail 3509 Not Applicable 
polypeptide ENSMUSP00000022744 Ensembl | MGI Sequence Detail 240 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016649 Glial cell line-derived neurotrophic factor
InterPro IPR001839 Transforming growth factor-beta, C-terminal
Protein Ontology PR:000007928 glial cell line-derived neurotrophic factor
References
(Earliest) J:38540 Lin LF, et al., GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]. Science. 1993 May 21;260(5111):1130-2
(Latest) J:219797 Ranghini EJ, et al., Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol. 2015 Mar 15;399(2):296-305
All references(263)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-35901, MGI:2145987

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory