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Gdnf Gene Detail
Summary
  • Symbol
    Gdnf
  • Name
    glial cell line derived neurotrophic factor
  • Synonyms
    glial cell line-derived neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:107430
    NCBI Gene: 14573
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:7810846-7837575 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26730 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.80 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GDNF, glial cell derived neurotrophic factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GDNF, glial cell derived neurotrophic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATF, ATF1, ATF2, HFB1-GDNF, HSCR3
  • Links
    NCBI Gene ID: 2668
    neXtProt AC: NX_P39905
    UniProt: P39905

  • Chr Location
    5p13.2; chr5:37812677-37840044 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gdnf mouse models; 3 with human GDNF associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    73 phenotypes from 7 alleles in 12 genetic backgrounds
    12 phenotypes from multigenic genotypes
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to lack of ureteric bud induction, bilateral renal agenesis, absence of enteric neurons, and neonatal death. Heterozygotes show renal phenotypes ranging from two small kidneys, often with abnormal shapes and cortical cysts, to unilateral renal agenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022144 Ensembl Gene Model | MGI Sequence Detail 26730 C57BL/6J ±  kb
    transcript ENSMUST00000022744 Ensembl | MGI Sequence Detail 3674 Not Applicable  
    polypeptide ENSMUSP00000022744 Ensembl | MGI Sequence Detail 240 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      33 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 4
      cDNA 20
      Primer pair 13
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35901, MGI:2145987
    References
    more
    • Summaries
      All 329
      Developmental Gene Expression 180
      Diseases 3
      Gene Ontology 20
      Phenotypes 98
    • Earliest
      J:38540 Lin LF, et al., GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]. Science. 1993 May 21;260(5111):1130-2
    • Latest
      J:263559 Yun K, et al., Constitutive metanephric mesenchyme-specific expression of interferon-gamma causes renal dysplasia by regulating Sall1 expression. PLoS One. 2018;13(5):e0197356

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory