Gdnf
Gene Detail

Symbol Name ID

Gdnf glial cell line derived neurotrophic factor MGI:107430

Synonyms

glial cell line-derived neurotrophic factor

Feature Type

protein coding gene

Genetic Map

Chromosome 15

3.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:7811011-7837575 bp, + strand From NCBI annotation of GRCm38   26565 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glial cell line-derived neurotrophic factor
Gene Tree: Gdnf

Human homologs

Human Homolog		GDNF, glial cell derived neurotrophic factor
NCBI Gene ID		2668
neXtProt AC		NX_P39905
Human Synonyms		ATF1, ATF2, HFB1-GDNF, HSCR3
Human Chr (Location)		5p13.1-p12; chr5:37812779-37839782 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human GDNF

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygous inactivation of this gene leads to lack of ureteric bud induction, bilateral renal agenesis, absence of enteric neurons, and neonatal death. Heterozygotes show renal phenotypes ranging from two small kidneys, often with abnormal shapes and cortical cysts, to unilateral renal agenesis.

 
Human Diseases Modeled Using Mouse Gdnf (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	branching involved in ureteric bud morphogenesis, cell proliferation, ...
Component	extracellular region, extracellular space, ...
Function	glial cell line-derived neurotrophic factor receptor binding, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (135 records)
Data Summary: Results (365)    Tissues (174)    Images (89)
Theiler Stages: 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	183
In situ reporter (knock in)	1
RT-PCR	181

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(4) cDNA(17) Primer pair(8) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022144 (Evidence)
Entrez Gene	14573 (Evidence)
UniGene	4679
DFCI	TC1591077, TC1679564
DoTS	DT.481635, DT.91446648
NIA Mouse Gene Index	U016047
Consensus CDS Project	CCDS27371.1
International Mouse Knockout Project Status	Gdnf

Sequences

Length	Strain/Species
genomic	14573	NCBI Gene Model | MGI Sequence Detail	26565	C57BL/6J
transcript	NM_010275	RefSeq | MGI Sequence Detail	3509	C57BL/6
polypeptide	P48540	UniProt | EBI | MGI Sequence Detail	211	Not Applicable

All sequences(22) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016649	Glial cell line-derived neurotrophic factor
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
Protein Ontology	PR:000007928	glial cell line-derived neurotrophic factor

Graphical View of Protein Domain Structure

References

(Earliest) J:38540 Lin LF, et al., GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]. Science. 1993 May 21;260(5111):1130-2
(Latest) J:192870 Biau S, et al., Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biol Open. 2013;2:144-155
All references(242)

Other accession IDs

MGD-MRK-35901, MGI:2145987