About   Help   FAQ
Gdnf Gene Detail
Summary
  • Symbol
    Gdnf
  • Name
    glial cell line derived neurotrophic factor
  • Synonyms
    glial cell line-derived neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:107430
    NCBI Gene: 14573
Location & Maps
more
  • Sequence Map
    Chr15:7811011-7837575 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26565 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.80 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GDNF, glial cell derived neurotrophic factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GDNF, glial cell derived neurotrophic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATF, ATF1, ATF2, HFB1-GDNF, HSCR3
  • Links
    NCBI Gene ID: 2668
    neXtProt AC: NX_P39905

  • Chr Location
    5p13.2; chr5:37812677-37839680 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gdnf mouse models; 3 with human GDNF associations

Human Disease Mouse Models
       Hirschsprung Disease, Susceptibility to, 3; HSCR3   OMIM: 613711 View 3 models
       Central Hypoventilation Syndrome, Congenital; CCHS   OMIM: 209880
Pheochromocytoma   OMIM: 171300
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 7 alleles in 12 genetic backgrounds
    12 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Targeted
    10
  • Transgenic
    4
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Gdnf
Homozygous inactivation of this gene leads to lack of ureteric bud induction, bilateral renal agenesis, absence of enteric neurons, and neonatal death. Heterozygotes show renal phenotypes ranging from two small kidneys, often with abnormal shapes and cortical cysts, to unilateral renal agenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022144 Ensembl Gene Model | MGI Sequence Detail 26565 C57BL/6J ±  kb
transcript ENSMUST00000022744 Ensembl | MGI Sequence Detail 3509 Not Applicable  
polypeptide ENSMUSP00000022744 Ensembl | MGI Sequence Detail 240 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    33 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 4
    cDNA 18
    Primer pair 9
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35901, MGI:2145987
References
more
  • Summaries
    All 277
    Developmental Gene Expression 163
    Diseases 3
    Gene Ontology 19
    Phenotypes 87
  • Earliest
    J:38540 Lin LF, et al., GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]. Science. 1993 May 21;260(5111):1130-2
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory