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Supt4a Gene Detail
Summary
  • Symbol
    Supt4a
  • Name
    suppressor of Ty 4A
  • Synonyms
    Supt4h, Supt4h1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107416
    NCBI Gene: 20922
  • Gene Overview
    MyGene.info: SUPT4H1
Location & Maps
more
  • Sequence Map
    Chr11:87737552-87743623 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6072 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 52.20 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SUPT4H1, SPT4 homolog, DSIF elongation factor subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SUPT4H1, SPT4 homolog, DSIF elongation factor subunit
    Orthology source: HomoloGene
  • Synonyms
    SPT4, SPT4H, Supt4a, SUPT4H
  • Links
    NCBI Gene ID: 6827
    neXtProt AC: NX_P63272

  • Chr Location
    17q22; chr17:58345175-58352238 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    5
  • Genomic Mutations
    2 involving Supt4a
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit embryonic lethality at E7.5. Mice heterozygous for a knock-out allele partially suppress the motor defects and premature death associated with Tg(HDexon1)62Gpb.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001315 VEGA Gene Model | MGI Sequence Detail 6072 C57BL/6J ±  kb
transcript OTTMUST00000002643 VEGA | MGI Sequence Detail 706 Not Applicable  
polypeptide OTTMUSP00000001305 VEGA | MGI Sequence Detail 117 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    21 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030299 transcription elongation factor SPT4
  • InterPro Domains
    IPR029040 RNA polymerase subunit RPABC4/transcription elongation factor Spt4
    IPR022800 Spt4/RpoE2 zinc finger
    IPR009287 Transcription initiation Spt4
    IPR016046 Transcription initiation Spt4-like
Molecular
Reagents
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  • All nucleic 118
    Genomic 1
    cDNA 115
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-35885, MGI:2143709
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:33855 Chiang PW, et al., Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene. Genomics. 1996 Jun 15;34(3):368-75
  • Latest
    J:224237 Cheng HM, et al., Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown. PLoS Genet. 2015 Mar;11(3):e1005043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory