About   Help   FAQ
Tnfsf10 Gene Detail
Summary
  • Symbol
    Tnfsf10
  • Name
    tumor necrosis factor (ligand) superfamily, member 10
  • Synonyms
    A330042I21Rik, APO-2L, Trail
  • Feature Type
    protein coding gene
  • IDs
    MGI:107414
    NCBI Gene: 22035
  • Gene Overview
    MyGene.info: TNFSF10
Location & Maps
more
  • Sequence Map
    Chr3:27317028-27342427 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25400 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 10.82 cM, cytoband A3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TNFSF10, tumor necrosis factor superfamily member 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNFSF10, tumor necrosis factor superfamily member 10
    Orthology source: HomoloGene
  • Synonyms
    Apo-2L, APO2L, CD253, TL2, TNLG6A, TRAIL
  • Links
    NCBI Gene ID: 8743
    neXtProt AC: NX_P50591

  • Chr Location
    3q26; chr3:172505508-172523507 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 5 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Tnfsf10
Homozygotes for a null allele show thymus hyperplasia, abnormal negative T cell selection, increased susceptibility to autoimmune diseases and to tumor initiation and metastasis, and resistance to induced hepatitis. Homozygotes for another null allele are unable to control A20 lymphoma progression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037571 VEGA Gene Model | MGI Sequence Detail 25400 C57BL/6J ±  kb
transcript OTTMUST00000096865 VEGA | MGI Sequence Detail 4993 Not Applicable  
polypeptide OTTMUSP00000054176 VEGA | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    174 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002106 tumor necrosis factor ligand superfamily member 10
  • InterPro Domains
    IPR021184 Tumour necrosis factor, conserved site
    IPR006052 Tumour necrosis factor domain
    IPR017355 Tumour necrosis factor ligand 10/11
    IPR008983 Tumour necrosis factor-like domain
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35883, MGI:2139709
References
more
  • Summaries
    All 109
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 63
  • Earliest
    J:30253 Wiley SR, et al., Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995 Dec;3(6):673-82
  • Latest
    J:232163 Collison A, et al., Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease. Am J Respir Cell Mol Biol. 2014 Jul;51(1):86-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory