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Tnfsf10
Gene Detail
Symbol

Name
ID
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
MGI:107414
Synonyms
A330042I21Rik, APO-2L, Trail
Feature Type
protein coding gene
Genetic Map
Chromosome 3
10.82 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:27317028-27342973 bp, + strand
From VEGA annotation of GRCm38

  25946 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TNFSF10
Protein SuperFamily: tumor necrosis factor ligand superfamily member, 10/11 types
Gene Tree: Tnfsf10

Human
homologs
TNFSF10, tumor necrosis factor (ligand) superfamily, member 10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8743
neXtProt AC: NX_P50591

Human Synonyms: Apo-2L, APO2L, CD253, TL2, TRAIL

Human Chr (Location): 3q26; chr3:172505508-172523507 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygotes for a null allele show thymus hyperplasia, abnormal negative T cell selection, increased susceptibility to autoimmune diseases and to tumor initiation and metastasis, and resistance to induced hepatitis. Homozygotes for another null allele are unable to control A20 lymphoma progression.
 
Interactions
Tnfsf10 interacts with 342 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, immune response, ...
Component extracellular exosome, extracellular space, ...
Function cytokine activity, tumor necrosis factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (66)    Tissues (43)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tnfsf10    NEW 
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000037571 (Evidence)
Ensembl Gene Model ENSMUSG00000039304 (Evidence)
Entrez Gene 22035 (Evidence)
UniGene 1062
DFCI TC1587074, TC1623777
DoTS DT.97400490, DT.60102805, DT.40148778, DT.101293201
NIA Mouse Gene Index U003094
Consensus CDS Project CCDS17272.1
International Mouse Phenotyping Consortium Status Tnfsf10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037571 VEGA Gene Model | MGI Sequence Detail 25946 C57BL/6J ±  kb
transcript OTTMUST00000096865 VEGA | MGI Sequence Detail 4993 Not Applicable 
polypeptide OTTMUSP00000054176 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR017355 Tumour necrosis factor ligand 10/11
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002106 tumor necrosis factor ligand superfamily member 10
References
(Earliest) J:30253 Wiley SR, et al., Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995 Dec;3(6):673-82
(Latest) J:215206 Lin YC, et al., Characterization of the role of tumor necrosis factor apoptosis inducing ligand (TRAIL) in spermatogenesis through the evaluation of trail gene-deficient mice. PLoS One. 2014;9(4):e93926
All references(109)
Other
accession IDs
MGD-MRK-35883, MGI:2139709

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory