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Tnfsf10
Gene Detail
 Symbol
Name
ID
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
MGI:107414
Synonyms A330042I21Rik, APO-2L, Trail
Feature Type protein coding gene
Genetic Map
Chromosome 3
10.82 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:27317028-27342427 bp, + strand
From VEGA annotation of GRCm38

  25400 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor ligand superfamily member, 10/11 types
Gene Tree: Tnfsf10

Human
homologs
Human Homolog TNFSF10, tumor necrosis factor (ligand) superfamily, member 10
NCBI Gene ID 8743
neXtProt AC  NX_P50591
Human Synonyms  Apo-2L, APO2L, CD253, TL2, TRAIL
Human Chr (Location)  3q26; chr3:172505508-172523507 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygotes for a null allele show thymus hyperplasia, abnormal negative T cell selection, increased susceptibility to autoimmune diseases and to tumor initiation and metastasis, and resistance to induced hepatitis. Homozygotes for another null allele are unable to control A20 lymphoma progression.
 
Interactions
Tnfsf10 interacts with 343 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, immune response, ...
Component extracellular space, extracellular vesicular exosome, ...
Function cytokine activity, tumor necrosis factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (66)    Tissues (43)    Images (15)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 66
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000037571 (Evidence)
Ensembl Gene ModelENSMUSG00000039304 (Evidence)
Entrez Gene22035 (Evidence)
UniGene1062
DFCITC1587074, TC1623777
DoTSDT.101293201, DT.40148778, DT.60102805, DT.97400490
NIA Mouse Gene IndexU003094
Consensus CDS ProjectCCDS17272.1
International Mouse Knockout Project StatusTnfsf10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037571 VEGA Gene Model | MGI Sequence Detail 25400 C57BL/6J ±  kb
transcript OTTMUST00000096865 VEGA | MGI Sequence Detail 4993 Not Applicable 
polypeptide OTTMUSP00000054176 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(178 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR017355 Tumour necrosis factor ligand 10/11
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000002106 tumor necrosis factor ligand superfamily member 10
References (Earliest) J:30253 Wiley SR, et al., Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995 Dec;3(6):673-82
(Latest) J:208773 Afshar-Sterle S, et al., Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med. 2014 Mar;20(3):283-90
All references(107)
Other
accession IDs
MGD-MRK-35883, MGI:2139709

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory