Tnfsf10 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
MGI:107414

22 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tnfsf10^{tm1b(KOMP)Wtsi}/Tnfsf10^{tm1b(KOMP)Wtsi} C57BL/6N-Tnfsf10^{tm1b(KOMP)Wtsi}/Ucd	increased circulating alanine transaminase level	J:211773
Tnfsf10^tm1Mjs/Tnfsf10^tm1Mjs B6.129-Tnfsf10^tm1Mjs	abnormal negative T cell selection	J:82145
	normal hematopoietic system phenotype	J:84838
	normal immune system phenotype	J:84838
	increased IgG1 level	J:82145
	increased IgG2a level	J:82145
	increased interferon-gamma secretion	J:82145
	increased interleukin-2 secretion	J:82145
	increased susceptibility to autoimmune diabetes	J:82145
	increased susceptibility to experimental autoimmune encephalomyelitis	J:101672
	increased susceptibility to induced arthritis	J:82145
	thymus hyperplasia	J:82145
Tnfsf10^tm1Mjs/Tnfsf10^tm1Mjs C.129-Tnfsf10^tm1Mjs	abnormal negative T cell selection	J:82145
	decreased susceptibility to bacterial infection	J:87620
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:87620
	normal hematopoietic system phenotype	J:84838
	normal immune system phenotype	J:84838
	impaired natural killer cell mediated cytotoxicity	J:73948
	increased incidence of induced tumors	J:73948
	increased incidence of tumors by chemical induction	J:73948
	liver inflammation	J:87620
	thymus hyperplasia	J:82145, J:84838
Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg B6.129-Tnfsf10^tm1Sdg	normal immune system phenotype	J:79085
Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg B6.129-Tnfsf10^tm1Sdg	normal neoplasm	J:79085
Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg C.129-Tnfsf10^tm1Sdg	increased susceptibility to induced morbidity/mortality	J:79085
Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg C.129-Tnfsf10^tm1Sdg	increased tumor growth/size	J:79085
Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg involves: 129 * C57BL/6	normal immune system phenotype	J:79085
Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg involves: 129 * C57BL/6	normal skeleton phenotype	J:79085

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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