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Tbr1
Gene Detail
 Symbol
Name
ID
Tbr1
T-box brain gene 1
MGI:107404
Feature Type protein coding gene
Genetic Map
Chromosome 2
35.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:61802930-61814114 bp, + strand
From VEGA annotation of GRCm38

  11185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tbr1

Human
homologs
Human Homolog TBR1, T-box, brain, 1
NCBI Gene ID 10716
neXtProt AC  NX_Q16650
Human Synonyms  TBR-1, TES-56
Human Chr (Location)  2q24; chr2:161416109-161425062 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null allele fail to feed and die on the second postnatal day displaying disrupted forebrain morphology and a hypoplastic olfactory bulb that lacks normal mitral and tufted cells and shows a striking reduction in mature olfactory bulb projection neurons.
 
Phenotype Images(2)
Interactions
Tbr1 interacts with 311 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process axon guidance, commitment of neuronal cell to specific neuron type in forebrain, ...
Component intracellular, nucleus
Function DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (315 records)
Data Summary: Results (295)    Tissues (206)    Images (57)
Theiler Stages: 9, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 21
RNA in situ 259
Northern blot 2
RT-PCR 13
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(13) Primer pair(6) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000013075 (Evidence)
Ensembl Gene ModelENSMUSG00000035033 (Evidence)
Entrez Gene21375 (Evidence)
DFCITC1579064, TC1626989
DoTSDT.60101040, DT.91314753, DT.97389757
NIA Mouse Gene IndexU001812, U328427
Consensus CDS ProjectCCDS16063.1
International Mouse Knockout Project StatusTbr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013075 VEGA Gene Model | MGI Sequence Detail 11185 C57BL/6J ±  kb
transcript OTTMUST00000031566 VEGA | MGI Sequence Detail 3977 Not Applicable 
polypeptide OTTMUSP00000014072 VEGA | MGI Sequence Detail 681 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016140 T-box brain protein 1
References (Earliest) J:27413 Bulfone A, et al., T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron. 1995 Jul;15(1):63-78
(Latest) J:209564 Karaca E, et al., Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 2014 Apr 24;157(3):636-50
All references(348)
Other
accession IDs
MGD-MRK-35872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory