Analysis Tools
behavior/neurological
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• mice show reduced habituation to the novel open-field environment
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• mice spend an increased amount of time in the center of the open-field test, indicating anxiolytic-like behavior
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• 3 month old males exhibit enhanced anxiety-like behavior, spending more time in the closed arms and less time in the open arms of the elevated plus-maze test and spending less time in the light chamber of the light-dark test
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• mice show modestly increased repetitive self-grooming during the light-off period, but not during the light-on period
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• mice show an increase in rearing in Laboras cages during the light-off period, but not during the light-on period
• however, mice show normal levels of locomotor activity in the open-field test
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• in Laboras cages, mice show modest hyperactivity during the first 6 hours on day 1 (light-off period), although total locomotion over 3 days does not change in light-off or light-on periods
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• 3 month old males exhibit reduced social interaction in direct social-interaction
• however, mice show normal social approach and social novelty recognition in the three-chamber test for social interaction and pups show normal levels of social communication by USVs upon separation from their mothers
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nervous system
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• the number of parvalbumin (PV)+ interneurons in superficial cortical layers of the cortex is decreased at 3 months of age, whereas their number is increased in deep cortical layers
• however, no differences in the total numbers of SST+, PV+, or VIP+ interneurons are seen and no difference in the thickness of the neocortex in the prelimbic region of the medial prefrontal cortex at P5
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• increase in frequency, but not amplitude, of spontaneous excitatory postsynaptic currents (sEPSCs) in layer 6 pyramidal neurons at 11-12 weeks of age
• however, no differences in neuronal excitability of mPFC layer 6 pyramidal neurons is seen
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• increase in the frequency, but not amplitude, of miniature inhibitory postsynaptic currents (mIPSCs) in layer 6 pyramidal neurons at 11-12 weeks of age indicating that inhibitory synaptic transmission onto medial prefrontal cortex (mPFC) layer 6 pyramidal neurons is increased
• increase in the frequency, but not amplitude, of spontaneous inhibitory postsynaptic currents (sIPSCs) in layer 6 pyramidal neurons at 11-12 weeks of age
• however, no differences in the frequency or amplitude of mEPSCs is seen
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:281878 | ||
