Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in cerebral cortex development; chromatin remodeling; and gene expression. Acts upstream of or within several processes, including brain development; conditioned taste aversion; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study autism spectrum disorder. Orthologous to human TBR1 (T-box brain transcription factor 1).