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Gene Detail
discs, large homolog 1 (Drosophila)
Synonyms B130052P05Rik, Dlgh1, SAP97
Feature Type protein coding gene
Genetic Map
Chromosome 16
22.40 cM
Detailed Genetic Map ± 1 cM

Mapping data(5)
Sequence Map
Chr16:31663443-31873350 bp, + strand
From VEGA annotation of GRCm38

  209908 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20869  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg1

Human Homolog DLG1, discs, large homolog 1 (Drosophila)
NCBI Gene ID 1739
neXtProt AC  NX_Q12959
Human Synonyms  dJ1061C18.1.1, DLGH1, hdlg, SAP97, SAP-97
Human Chr (Location)  3q29; chr3:197042560-197298631 (-)  GRCh38
alleles, and
All mutations/alleles(36) : Gene trapped(25) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a gene trap allele exhibit neonatal lethality, craniofacial defects, and abnormal eye morphology. Mice homozygous for knock-out alleles exhibit neonatal lethality, kidney defects, reproductive organ morphology, and cleft palate.
Phenotype Images(4)
Dlg1 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (105 annotations)
Process actin filament organization, activation of protein kinase activity, ...
Component basal lamina, basal plasma membrane, ...
Function ion channel binding, ionotropic glutamate receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (16 records)
Data Summary: Results (201)    Tissues (94)    Images (47)
Theiler Stages: 13, 15, 17, 19, 20, 22, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 111
In situ reporter (knock in) 71
Northern blot 6
Western blot 2
cDNA source data(155)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(157) cDNA(157)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000016269 (Evidence)
Ensembl Gene ModelENSMUSG00000022770 (Evidence)
Entrez Gene13383 (Evidence)
DFCITC1575056, TC1587181, TC1590440, TC1599465, TC1623031, TC1630234
DoTSDT.101258203, DT.101739534, DT.110718532, DT.110718548, DT.492563, DT.91591755, DT.94140620, DT.94326012, DT.97384214
NIA Mouse Gene IndexU043513
Consensus CDS ProjectCCDS28107.1, CCDS57025.1, CCDS57026.1, CCDS57027.1
International Mouse Knockout Project StatusDlg1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016269 VEGA Gene Model | MGI Sequence Detail 209908 C57BL/6J ±  kb
transcript OTTMUST00000039019 VEGA | MGI Sequence Detail 4663 Not Applicable 
polypeptide OTTMUSP00000017432 VEGA | MGI Sequence Detail 927 Not Applicable 

For the selected sequences
All sequences(135) RefSeq(40) UniProt(11)
Polymorphisms RFLP(2) : SNPs within 2kb(903 from dbSNP Build 137)
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR004172 L27
InterPro IPR015143 L27-1
InterPro IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro IPR016313 Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro IPR019583 PDZ-associated domain of NMDA receptors
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006511 disks large homolog 1
References (Earliest) J:34777 Burgess DL, et al., Dlgh1, a mouse homolog of the drosophila discs-large gene, is located on chromosome 16. Mamm Genome. 1996 Aug;7(8):623-4
(Latest) J:212403 Kim ST, et al., DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis. Dev Biol. 2014 Jun 15;390(2):160-9
All references(90)
accession IDs
MGD-MRK-35696, MGI:2444750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory