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Dlg1 Gene Detail
Summary
  • Symbol
    Dlg1
  • Name
    discs large MAGUK scaffold protein 1
  • Synonyms
    B130052P05Rik, Dlgh1, SAP97
  • Feature Type
    protein coding gene
  • IDs
    MGI:107231
    NCBI Gene: 13383
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:31482261-31692174 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.40 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    880 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107231
 protein coding gene Chr16:31482261-31693947 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022721
 protein coding gene Chr16:29654533-29868928 (+)
A/J MGP_AJ_G0022686
 protein coding gene Chr16:28293758-28501832 (+)
AKR/J MGP_AKRJ_G0022659
 protein coding gene Chr16:29332459-29537749 (+)
BALB/cJ MGP_BALBcJ_G0022688
 protein coding gene Chr16:28445400-28653807 (+)
C3H/HeJ MGP_C3HHeJ_G0022453
 protein coding gene Chr16:29452112-29661558 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023137
 protein coding gene Chr16:30295079-30518563 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020655
 protein coding gene Chr16:28668243-28869828 (+)
CAST/EiJ MGP_CASTEiJ_G0021981
 protein coding gene Chr16:29561529-29777705 (+)
CBA/J MGP_CBAJ_G0022423
 protein coding gene Chr16:31547171-31773562 (+)
DBA/2J MGP_DBA2J_G0022556
 protein coding gene Chr16:28144450-28348764 (+)
FVB/NJ MGP_FVBNJ_G0022531
 protein coding gene Chr16:28117894-28331802 (+)
LP/J MGP_LPJ_G0022623
 protein coding gene Chr16:29449858-29665148 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022550
 protein coding gene Chr16:31024376-31241454 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023149
 protein coding gene Chr16:29299161-29509119 (+)
PWK/PhJ MGP_PWKPhJ_G0021720
 protein coding gene Chr16:28450060-28660255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021551
 protein coding gene Chr16:29068839-29293187 (+)
WSB/EiJ MGP_WSBEiJ_G0022025
 protein coding gene Chr16:29233995-29452939 (+)



Homology
more
  • Human Ortholog
    DLG1, discs large MAGUK scaffold protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLG1, discs large MAGUK scaffold protein 1
  • Synonyms
    DLGH1, hdlg, SAP97, SAP-97
  • Links
    NCBI Gene ID: 1739
    neXtProt AC: NX_Q12959
    UniProt: Q12959

  • Chr Location
    3q29; chr3:197042560-197299272 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human DLG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 8 alleles in 9 genetic backgrounds
    4 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit neonatal lethality, craniofacial defects, and abnormal eye morphology. Mice homozygous for knock-out alleles exhibit neonatal lethality, kidney defects, reproductive organ morphology, and cleft palate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    167
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    133
  • cDNA Data
    157
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13383 NCBI Gene Model | MGI Sequence Detail 209914 C57BL/6J ±  kb
    transcript NM_007862 RefSeq | MGI Sequence Detail 4777 C57BL/6  
    polypeptide Q811D0 UniProt | EBI | MGI Sequence Detail 905 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 162
      cDNA 159
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35696, MGI:2444750
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 28
      Gene Ontology 35
      Phenotypes 45
    • Earliest
      J:34777 Burgess DL, et al., Dlgh1, a mouse homolog of the drosophila discs-large gene, is located on chromosome 16. Mamm Genome. 1996 Aug;7(8):623-4
    • Latest
      J:325117 Romero DM, et al., Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development. Nat Commun. 2022 May 18;13(1):2746
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/09/2022
    MGI 6.21     		The Jackson Laboratory