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Dlg1 Gene Detail
Summary
  • Symbol
    Dlg1
  • Name
    discs, large homolog 1 (Drosophila)
  • Synonyms
    B130052P05Rik, Dlgh1, SAP97
  • Feature Type
    protein coding gene
  • IDs
    MGI:107231
    NCBI Gene: 13383
  • Gene Overview
    MyGene.info: DLG1
Location & Maps
more
  • Sequence Map
    Chr16:31663443-31873350 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      209908 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.40 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DLG1, discs large MAGUK scaffold protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLG1, discs large MAGUK scaffold protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ1061C18.1.1, DLGH1, hdlg, SAP97, SAP-97
  • Links
    NCBI Gene ID: 1739
    neXtProt AC: NX_Q12959
    UniProt: Q12959

  • Chr Location
    3q29; chr3:197042560-197299272 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 8 alleles in 9 genetic backgrounds
    4 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit neonatal lethality, craniofacial defects, and abnormal eye morphology. Mice homozygous for knock-out alleles exhibit neonatal lethality, kidney defects, reproductive organ morphology, and cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    134
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    201
  • Tissues
    94
  • cDNA Data
    155
  • Literature Summary
    20
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016269 VEGA Gene Model | MGI Sequence Detail 209908 C57BL/6J ±  kb
transcript OTTMUST00000039019 VEGA | MGI Sequence Detail 4663 Not Applicable  
polypeptide OTTMUSP00000017432 VEGA | MGI Sequence Detail 927 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    892 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 157
    cDNA 157

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35696, MGI:2444750
References
more
  • Summaries
    All 97
    Developmental Gene Expression 20
    Gene Ontology 31
    Phenotypes 31
  • Earliest
    J:34777 Burgess DL, et al., Dlgh1, a mouse homolog of the drosophila discs-large gene, is located on chromosome 16. Mamm Genome. 1996 Aug;7(8):623-4
  • Latest
    J:239017 Steinmetz CC, et al., Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell Rep. 2016 Sep 06;16(10):2711-22
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory