Dlg1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dlg1
discs large MAGUK scaffold protein 1
MGI:107231

78 phenotypes from 8 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dlg1^{Gt(gt1.8geo)1Ber}/Dlg1^{Gt(gt1.8geo)1Ber} involves: 129S1/Sv * 129X1/SvJ * ICR	abnormal kidney development	J:114313
	abnormal lens epithelium morphology	J:86871
	abnormal palatal shelf elevation	J:67360
	absent gastric milk in neonates	J:67360
	cleft secondary palate	J:67360
	curly tail	J:67360
	cyanosis	J:67360
	decreased body size	J:67360
	decreased embryo weight	J:114313
	decreased fetal size	J:114313
	decreased nephron number	J:114313
	decreased renal glomerulus number	J:114313
	distended abdomen	J:67360
	domed cranium	J:67360
	fetal growth retardation	J:67360
	kinked tail	J:67360
	mandible hypoplasia	J:67360
	meteorism	J:67360
	neonatal lethality, complete penetrance	J:67360
	premaxilla hypoplasia	J:67360
	short snout	J:67360
	small metanephros	J:114313
Dlg1^{Gt(RRN196)Byg}/Dlg1^{Gt(RRN196)Byg} involves: 129P2/OlaHsd * C57BL/6J	neonatal lethality, complete penetrance	J:191788
Dlg1^tm1.1Agri/Dlg1^tm1.1Agri involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	normal vision/eye phenotype	J:151538
Dlg1^tm1.1Agri/Dlg1^tm1.1Agri Tg(Cryaa-cre)10Mlr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal lens development	J:151538
	abnormal lens epithelium morphology	J:151538
	abnormal lens fiber morphology	J:151538
	abnormal lens morphology	J:151538
	cataract	J:151538
	disorganized lens bow	J:151538
	increased lens epithelium apoptosis	J:151538
	increased lens fiber apoptosis	J:151538
Dlg1^tm1.1Agri/Dlg1^tm1.1Agri Tg(Cryaa-cre,Tyr)39Mlr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal lens development	J:151538
	abnormal lens fiber morphology	J:151538
	abnormal lens morphology	J:151538
	disorganized lens bow	J:151538
	increased lens fiber apoptosis	J:151538
Dlg1^tm1.2Agri/Dlg1^tm1.2Agri involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal craniofacial morphology	J:151538
	abnormal lens morphology	J:151538
Dlg1^tm1Jhm/Dlg1^tm1Jhm involves: 129 * C57BL/6J	abnormal ureter development	J:118250
	abnormal ureter morphology	J:118250
	abnormal ureter smooth muscle morphology	J:118250
	abnormal ureteric bud morphology	J:118250
	decreased nephron number	J:118250
	dilated kidney collecting duct	J:118250
	hydronephrosis	J:118250
	hydroureter	J:118250
	impaired branching involved in ureteric bud morphogenesis	J:118250
	impaired smooth muscle contractility	J:118250
	impaired ureteric peristalsis	J:118250
	neonatal lethality, complete penetrance	J:118250
	renal hypoplasia	J:118250
	respiratory distress	J:118250
	short ureter	J:118250
	single kidney	J:118250
Dlg1^tm1Jhm/Dlg1^tm1Jhm Tg(Vil1-cre)997Gum/0 involves: 129 * C57BL/6 * SJL	abnormal enterocyte morphology	J:146174
Dlg1^tm1Rlh/Dlg1^tm1.1Rlh Tg(Mpz-cre)26Mes/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac	normal nervous system phenotype	J:202688
Dlg1^tm1Rlh/Dlg1^tm1Rlh Mnx1^tm4(cre)Tmj/Mnx1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal dendrite morphology	J:141127
Dlg1^tm1Rlh/Dlg1^tm1Rlh Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:191788
	abnormal cytokine secretion	J:191788
	abnormal T-helper 1 physiology	J:191788
	abnormal T-helper 2 physiology	J:191788
	decreased interferon-gamma secretion	J:191788
	decreased interleukin-2 secretion	J:191788
	decreased tumor necrosis factor secretion	J:191788
	increased interleukin-4 secretion	J:191788
	increased interleukin-5 secretion	J:191788
Dlg1^tm1Rlh/Dlg1^tm1Rlh Tg(CMV-cre)1Nagy/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal craniofacial morphology	J:141127
	neonatal lethality	J:141127
Dlg1^tm1Rlh/Dlg1^tm1Rlh Tg(Mpz-cre)26Mes/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac	hypermyelination	J:202688
Dlg1^tm1Taki/Dlg1^tm1Taki involves: C57BL/6 * CBA	abnormal intestine morphology	J:121262
	abnormal metanephric mesenchyme morphology	J:121262
	abnormal Mullerian duct morphology	J:121262
	abnormal reproductive system morphology	J:121262
	abnormal ureter development	J:121262
	abnormal ureter morphology	J:121262
	abnormal ureter urothelium morphology	J:121262
	abnormal uterus morphology	J:121262
	abnormal Wolffian duct morphology	J:121262
	absent seminal vesicle	J:121262
	absent vagina	J:121262
	bifid ureter	J:121262
	blind uterus	J:121262
	cleft palate	J:121262
	cryptorchism	J:121262
	decreased body length	J:121262
	decreased lung weight	J:121262
	dilated ureter	J:121262
	ectopic ovary	J:121262
	hydronephrosis	J:121262
	large ureter	J:121262
	neonatal lethality, complete penetrance	J:121262
	renal hypoplasia	J:121262
	ureter hypoplasia	J:121262

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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