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Bcl6 Gene Detail
Summary
  • Symbol
    Bcl6
  • Name
    B cell leukemia/lymphoma 6
  • Synonyms
    Bcl5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107187
    NCBI Gene: 12053
  • Gene Overview
    MyGene.info: BCL6
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:23965052-23988612 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 15.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107187
protein coding gene Chr16:23965052-23988852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022688
protein coding gene Chr16:21570539-21594975 (-)
A/J MGP_AJ_G0022650
protein coding gene Chr16:20551755-20575819 (-)
AKR/J MGP_AKRJ_G0022624
protein coding gene Chr16:21418129-21441797 (-)
BALB/cJ MGP_BALBcJ_G0022655
protein coding gene Chr16:20749511-20773346 (-)
C3H/HeJ MGP_C3HHeJ_G0022419
protein coding gene Chr16:21539807-21563794 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023104
protein coding gene Chr16:22105576-22130646 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020622
protein coding gene Chr16:21178543-21202239 (-)
CAST/EiJ MGP_CASTEiJ_G0021948
protein coding gene Chr16:21540292-21569763 (-)
CBA/J MGP_CBAJ_G0022390
protein coding gene Chr16:23022799-23051865 (-)
DBA/2J MGP_DBA2J_G0022522
protein coding gene Chr16:20507732-20531357 (-)
FVB/NJ MGP_FVBNJ_G0022498
protein coding gene Chr16:20507085-20532309 (-)
LP/J MGP_LPJ_G0022590
protein coding gene Chr16:21372959-21398450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022517
protein coding gene Chr16:22491523-22515246 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023116
protein coding gene Chr16:21374124-21400344 (-)
PWK/PhJ MGP_PWKPhJ_G0021687
protein coding gene Chr16:20785748-20809999 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021518
protein coding gene Chr16:21108619-21134832 (-)
WSB/EiJ MGP_WSBEiJ_G0021992
protein coding gene Chr16:21330260-21356097 (-)



Homology
more
  • Human Ortholog
    BCL6, BCL6, transcription repressor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCL6, BCL6, transcription repressor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
  • Links
    NCBI Gene ID: 604
    neXtProt AC: NX_P41182
    UniProt: P41182

  • Chr Location
    3q27.3; chr3:187721377-187745725 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7640
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BCL6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 9 alleles in 13 genetic backgrounds
    8 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants develop myocarditis and pulmonary vasculitis, show impaired germinal center formation in the spleen, and display T helper 2 cell hyperimmune responsiveness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12053 NCBI Gene Model | MGI Sequence Detail 23561 C57BL/6J ±  kb
    transcript NM_001348026 RefSeq | MGI Sequence Detail 4744 C57BL/6  
    polypeptide P41183 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 54
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35648, MGI:1277984
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 20
      Gene Ontology 36
      Phenotypes 97
    • Earliest
      J:29534 Fukuda T, et al., The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. Oncogene. 1995 Oct 19;11(8):1657-63
    • Latest
      J:259699 Gaddis DE, et al., Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. Nat Commun. 2018 Mar 15;9(1):1095

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory