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Bcl6 Gene Detail
Summary
  • Symbol
    Bcl6
  • Name
    B cell leukemia/lymphoma 6
  • Synonyms
    Bcl5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107187
    NCBI Gene: 12053
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
  • Regulated by
    Rr394 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr16:23783802-23807602 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 15.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    484 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107187
 protein coding gene Chr16:23780058-23807602 (-)
129S1/SvImJ ENSMUSG00200036007
 protein coding gene Chr16:20787903-20811706 (-)
A/J ENSMUSG00195028095
 protein coding gene Chr16:20342484-20366295 (-)
AKR/J ENSMUSG00220027652
 protein coding gene Chr16:20661919-20685725 (-)
BALB/cJ ENSMUSG00180028409
 protein coding gene Chr16:20583062-20606871 (-)
C3H/HeJ ENSMUSG00175034991
 protein coding gene Chr16:20736694-20760509 (-)
C57BL/6NJ ENSMUSG00215010814
 protein coding gene Chr16:20455158-20478965 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020622
 protein coding gene Chr16:21178543-21202239 (-)
CAST/EiJ ENSTCUG00005030867
 protein coding gene Chr16:21058901-21082682 (-)
CBA/J ENSMUSG00210031385
 protein coding gene Chr16:20758351-20782159 (-)
DBA/2J ENSMUSG00185018598
 protein coding gene Chr16:20697143-20720948 (-)
FVB/NJ ENSMUSG00205020198
 protein coding gene Chr16:20689114-20712933 (-)
JF1/MsJ ENSUMUG00000016623
 protein coding gene Chr16:20922838-20946681 (-)
LP/J ENSMUSG00230031537
 protein coding gene Chr16:23267321-23291115 (-)
NOD/ShiLtJ ENSMUSG00190023677
 protein coding gene Chr16:20829763-20853569 (-)
NZO/HlLtJ ENSMUSG00225036780
 protein coding gene Chr16:26518547-26542351 (-)
PWK/PhJ ENSLUMG00010031349
 protein coding gene Chr16:20732836-20756734 (-)
SPRET/EiJ ENSMSPG00010017625
 protein coding gene Chr16:20630661-20654363 (-)
WSB/EiJ ENSIUOG00005031501
 protein coding gene Chr16:20949603-20973360 (-)



Homology
more
  • Human Ortholog
    BCL6, BCL6 transcription repressor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL6, BCL6 transcription repressor
  • Synonyms
    BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
  • Links
    NCBI Gene ID: 604
    UniProt: P41182

  • Chr Location
    3q27.3; chr3:187721377-187745725 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BCL6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 8 alleles in 13 genetic backgrounds
    20 phenotypes from multigenic genotypes
    239 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants develop myocarditis and pulmonary vasculitis, show impaired germinal center formation in the spleen, and display T helper 2 cell hyperimmune responsiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    112
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    173
  • cDNA Data
    57
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022508 Ensembl Gene Model | MGI Sequence Detail 23801 C57BL/6J ±  kb
    transcript ENSMUST00000023151 Ensembl | MGI Sequence Detail 3525 Not Applicable  
    polypeptide ENSMUSP00000023151 Ensembl | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 58
      Primer pair 7
      Other 4
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35648, MGI:1277984
    References
    more
    • Summaries
      All 445
      Developmental Gene Expression 29
      Gene Ontology 36
      Phenotypes 239
    • Earliest
      J:29534 Fukuda T, et al., The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. Oncogene. 1995 Oct 19;11(8):1657-63
    • Latest
      J:390490 Pelzer B, et al., SPEN Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities. Cancer Discov. 2026 Aug 3;16(8):1666-1690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory