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Bcl6
Gene Detail
Symbol

Name
ID
Bcl6
B cell leukemia/lymphoma 6
MGI:107187
Synonyms
Bcl5
Feature Type
protein coding gene
Genetic Map
Chromosome 16
15.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:23965052-23988852 bp, - strand
From VEGA annotation of GRCm38

  23801 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BCL6
Gene Tree: Bcl6

Human
homologs
BCL6, B-cell CLL/lymphoma 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 604
neXtProt AC: NX_P41182

Human Synonyms: BCL5, BCL6A, LAZ3, ZBTB27, ZNF51

Human Chr (Location): 3q27; chr3:187721377-187745725 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(3) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants develop myocarditis and pulmonary vasculitis, show impaired germinal center formation in the spleen, and display T helper 2 cell hyperimmune responsiveness.
 
Interactions
Bcl6 interacts with 297 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process actin cytoskeleton organization, B cell differentiation, ...
Component intracellular, nucleus, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (219)    Tissues (124)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
Northern blot 16
RT-PCR 97
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bcl6    NEW 
Molecular
reagents
All nucleic(56) cDNA(52) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027148 (Evidence)
Ensembl Gene Model ENSMUSG00000022508 (Evidence)
Entrez Gene 12053 (Evidence)
UniGene 347398
DFCI TC1576873
DoTS DT.101359312, DT.87072441
NIA Mouse Gene Index U036928
Consensus CDS Project CCDS28082.1
International Mouse Phenotyping Consortium Status Bcl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027148 VEGA Gene Model | MGI Sequence Detail 23801 C57BL/6J ±  kb
transcript OTTMUST00000067152 VEGA | MGI Sequence Detail 3525 Not Applicable 
polypeptide OTTMUSP00000033748 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000003450 B-cell lymphoma 6 protein
References
(Earliest) J:29534 Fukuda T, et al., The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. Oncogene. 1995 Oct 19;11(8):1657-63
(Latest) J:220339 Fujie A, et al., Bcl6 promotes osteoblastogenesis through Stat1 inhibition. Biochem Biophys Res Commun. 2015 Feb 13;457(3):451-6
All references(134)
Other
accession IDs
MGD-MRK-35648, MGI:1277984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory