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Bcl6
Gene Detail
Symbol

Name
ID
Bcl6
B cell leukemia/lymphoma 6
MGI:107187
Synonyms
Bcl5
Feature Type
protein coding gene
Genetic Map
Chromosome 16
15.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:23965052-23988852 bp, - strand
From VEGA annotation of GRCm38

  23801 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bcl6

Human
homologs
Human Homolog BCL6, B-cell CLL/lymphoma 6
NCBI Gene ID 604
neXtProt AC  NX_P41182
Human Synonyms  BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Human Chr (Location)  3q27; chr3:187721377-187745725 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(3) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants develop myocarditis and pulmonary vasculitis, show impaired germinal center formation in the spleen, and display T helper 2 cell hyperimmune responsiveness.
 
Interactions
Bcl6 interacts with 298 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process actin cytoskeleton organization, B cell differentiation, ...
Component intracellular, nucleus, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (219)    Tissues (124)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
Northern blot 16
RT-PCR 97
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) cDNA(52) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027148 (Evidence)
Ensembl Gene ModelENSMUSG00000022508 (Evidence)
Entrez Gene12053 (Evidence)
UniGene347398
DFCITC1576873
DoTSDT.101359312, DT.87072441
NIA Mouse Gene IndexU036928
Consensus CDS ProjectCCDS28082.1
International Mouse Knockout Project StatusBcl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027148 VEGA Gene Model | MGI Sequence Detail 23801 C57BL/6J ±  kb
transcript OTTMUST00000067152 VEGA | MGI Sequence Detail 3525 Not Applicable 
polypeptide OTTMUSP00000033748 VEGA | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000003450 B-cell lymphoma 6 protein
References
(Earliest) J:29534 Fukuda T, et al., The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. Oncogene. 1995 Oct 19;11(8):1657-63
(Latest) J:213941 Ise W, et al., Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11792-7
All references(130)
Other
accession IDs
MGD-MRK-35648, MGI:1277984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory