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Ptpn22 Gene Detail
Summary
  • Symbol
    Ptpn22
  • Name
    protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
  • Synonyms
    70zpep, Ptpn8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107170
    NCBI Gene: 19260
  • Gene Overview
    MyGene.info: PTPN22
Location & Maps
more
  • Sequence Map
    Chr3:103859795-103912247 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52453 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PTPN22, protein tyrosine phosphatase, non-receptor type 22
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPN22, protein tyrosine phosphatase, non-receptor type 22
    Orthology source: HomoloGene
  • Synonyms
    LYP, LYP1, LYP2, PEP, PTPN8
  • Links
    NCBI Gene ID: 26191
    neXtProt AC: NX_Q9Y2R2

  • Chr Location
    1p13.2; chr1:113813811-113871757 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human PTPN22 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
Rheumatoid Arthritis; RA   OMIM: 180300
Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 5 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    5 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Ptpn22
  • Incidental Mutations
Homozygous null mice display antigen dependent increases in T cell proliferation and cytokine production, enlarged spleens and lymph nodes, increased spontaneous germinal center formation, increased B cell numbers, and increased serum IgG and IgE levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022455 VEGA Gene Model | MGI Sequence Detail 52453 C57BL/6J ±  kb
transcript OTTMUST00000053696 VEGA | MGI Sequence Detail 2743 Not Applicable  
polypeptide OTTMUSP00000025543 VEGA | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    505 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013457 tyrosine-protein phosphatase non-receptor type 22
  • PDB
  • EC
  • InterPro Domains
    IPR016276 Non-receptor tyrosine-protein phosphatase 22
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35631
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:32702 Matthews RJ, et al., Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol. 1992 May;12(5):2396-405
  • Latest
    J:226353 Holmes DA, et al., Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-alpha receptor signaling. J Exp Med. 2015 Jun 29;212(7):1081-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory