About   Help   FAQ
Ptpn22
Gene Detail
Symbol

Name
ID
Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
MGI:107170
Synonyms
70zpep, Ptpn8
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.52 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:103859795-103912247 bp, + strand
From VEGA annotation of GRCm38

  52453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 8/22 types
Gene Tree: Ptpn22

Human
homologs
Human Homolog PTPN22, protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
NCBI Gene ID 26191
neXtProt AC  NX_Q9Y2R2
Human Synonyms  LYP, LYP1, LYP2, PEP, PTPN8
Human Chr (Location)  1p13.2; chr1:113813811-113871753 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PTPN22
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display antigen dependent increases in T cell proliferation and cytokine production, enlarged spleens and lymph nodes, increased spontaneous germinal center formation, increased B cell numbers, and increased serum IgG and IgE levels.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ptpn22 interacts with 119 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process dephosphorylation, immune system process, ...
Component cytoplasm, cytoplasmic side of plasma membrane, ...
Function hydrolase activity, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (10)    Tissues (3)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) cDNA(49)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022455 (Evidence)
Ensembl Gene ModelENSMUSG00000027843 (Evidence)
Entrez Gene19260 (Evidence)
UniGene395
DFCITC1579598
DoTSDT.101287463, DT.489539
NIA Mouse Gene IndexU003673
EC3.1.3.48
PDB1JEG
Consensus CDS ProjectCCDS38577.1
International Mouse Knockout Project StatusPtpn22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022455 VEGA Gene Model | MGI Sequence Detail 52453 C57BL/6J ±  kb
transcript OTTMUST00000053696 VEGA | MGI Sequence Detail 2740 Not Applicable 
polypeptide OTTMUSP00000025543 VEGA | MGI Sequence Detail 802 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(506 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016276 Non-receptor tyrosine-protein phosphatase, 8/22
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013457 tyrosine-protein phosphatase non-receptor type 22
References
(Earliest) J:32702 Matthews RJ, et al., Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol. 1992 May;12(5):2396-405
(Latest) J:208596 Zheng P, et al., PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant. Diabetes. 2013 Mar;62(3):896-904
All references(45)
Other
accession IDs
MGD-MRK-35631

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory