Symbol
Name
ID

Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
MGI:107170

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Abnormality of chromosome stability

Chromosome breakage

Abnormality of metabolism/homeostasis

Hyperkalemia

Hyponatremia

Decreased level of 1,5 anhydroglucitol in serum

Hyperbilirubinemia

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Elevated circulating C-reactive protein concentration

Elevated circulating hepatic transaminase concentration

Elevated circulating alkaline phosphatase concentration

Elevated erythrocyte sedimentation rate

Hyperglycemia

Hypoglycemia

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Ketoacidosis

Joint swelling

Fever

Hematuria

Pyuria

Decreased level of D-mannose in urine

Proteinuria

Increased circulating free T3

Increased circulating free T4 concentration

Decreased thyroid-stimulating hormone level

Disease(s) Associated with PTPN22

Addison's disease

Behcet's disease

coronary artery disease

graft-versus-host disease

Graves' disease

rheumatoid arthritis

Sjogren's syndrome

systemic lupus erythematosus

systemic scleroderma

temporal arteritis

type 1 diabetes mellitus

Mouse Phenotypes		increased physiological sensitivity to xenobiotic
Availability	Mouse Genotype	increased physiological sensitivity to xenobiotic
	Ptpn22^tm1.1Draw/Ptpn22^tm1.1Draw

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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