Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables SH3 domain binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including regulation of T cell activation; regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within T cell differentiation and T cell receptor signaling pathway. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); graft-versus-host disease; and pulmonary tuberculosis. Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22).