Mttp
Gene Detail

Symbol Name ID

Mttp microsomal triglyceride transfer protein MGI:106926

Synonyms

1810043K16Rik, MTP

Feature Type

protein coding gene

Genetic Map

Chromosome 3

64.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr3:138089855-138143388 bp, - strand From NCBI annotation of GRCm38   53534 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; hamster, golden    (Mammalian Orthology)
Comparative Map (Mouse/Human Mttp ± 2 cM)

Gene Tree: Mttp

Human ortholog

MTTP microsomal triglyceride transfer protein NCBI Gene ID 4547
Human Synonyms: ABL, MTP
Human Chr4:100485240-100545154 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human MTTP (2)

Alleles and phenotypes

All alleles(14) : Targeted(5) Gene trapped(9)
 

Most embryos homozygous for a reporter allele die at midgestation displaying delayed growth, neurodevelopmental anomalies, impaired erythropoiesis, deficient yolk sac lipoprotein production, hemorrhage and necrosis. Heterozygous mutant mice display altered plasma lipid and lipoprotein profiles.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cholesterol homeostasis, cholesterol metabolic process, ...
Component	basolateral plasma membrane, brush border membrane, ...
Function	apolipoprotein binding, lipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (81)    Tissues (47)    Images (20)
Theiler Stages: 11, 15, 17, 19, 20, 21, 22, 24, 26, 28

Assay Type	Results
RNA in situ	53
Northern blot	1
Western blot	6
RT-PCR	8
RNase protection	13

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(54) cDNA(52) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000028158 (Evidence)
Entrez Gene	17777 (Evidence)
UniGene	2941
DFCI	TC1585247, TC1633183, TC1655427
DoTS	DT.103564306, DT.532212, DT.97385622
Consensus CDS Project	CCDS38650.1, CCDS51080.1
International Mouse Knockout Project Status	Mttp

Sequences

Length	Strain/Species
genomic	17777	NCBI Gene Model | MGI Sequence Detail	53534	C57BL/6J
transcript	NM_001163457	RefSeq | MGI Sequence Detail	4272	C57BL/6
polypeptide	O08601	UniProt | EBI | MGI Sequence Detail	894	Not Applicable

All sequences(27) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(380 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015819	Lipid transport protein, beta-sheet shell
InterPro	IPR001747	Lipid transport protein, N-terminal
InterPro	IPR015816	Vitellinogen, beta-sheet N-terminal
InterPro	IPR011030	Vitellinogen, superhelical
Protein Ontology	PR:000003392	microsomal triglyceride transfer protein large subunit

Graphical View of Protein Domain Structure

References

(Earliest) J:42428 Knecht TP, et al., The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis. Adv Genet. 1995;32:141-98
(Latest) J:183750 Feig JE, et al., Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation. 2011 Mar 8;123(9):989-98
All references(69)

Other accession IDs

MGD-MRK-35387, MGI:1917046