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Mttp Gene Detail
Summary
  • Symbol
    Mttp
  • Name
    microsomal triglyceride transfer protein
  • Synonyms
    1810043K16Rik, MTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:106926
    NCBI Gene: 17777
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:138089854-138144968 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55115 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 64.06 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABL, MTP
  • Links
    NCBI Gene ID: 4547
    neXtProt AC: NX_P55157
    UniProt: P55157

  • Chr Location
    4q23; chr4:99564078-99623997 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 212
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MTTP
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human MTTP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most embryos homozygous for a reporter allele die at midgestation displaying delayed growth, neurodevelopmental anomalies, impaired erythropoiesis, deficient yolk sac lipoprotein production, hemorrhage and necrosis. Heterozygous mutant mice display altered plasma lipid and lipoprotein profiles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000052744 VEGA Gene Model | MGI Sequence Detail 55115 C57BL/6J ±  kb
    transcript OTTMUST00000132050 VEGA | MGI Sequence Detail 3072 Not Applicable  
    polypeptide OTTMUSP00000070472 VEGA | MGI Sequence Detail 909 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      680 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR015819 Lipid transport protein, beta-sheet shell
      IPR001747 Lipid transport protein, N-terminal
      IPR011030 Lipovitellin-phosvitin complex, superhelical domain
      IPR015816 Vitellinogen, beta-sheet N-terminal
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 53
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35387, MGI:1917046
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 51
    • Earliest
      J:42428 Knecht TP, et al., The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis. Adv Genet. 1995;32:141-98
    • Latest
      J:263839 Haider A, et al., PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress. Dev Cell. 2018 May 21;45(4):481-495.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory