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Mttp
Gene Detail
 Symbol
Name
ID
Mttp
microsomal triglyceride transfer protein
MGI:106926
Synonyms 1810043K16Rik, MTP
Feature Type protein coding gene
Genetic Map
Chromosome 3
64.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr3:138089855-138143388 bp, - strand
From NCBI annotation of GRCm38

  53534 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mttp

Human
homologs
Human Homolog MTTP, microsomal triglyceride transfer protein
NCBI Gene ID 4547
neXtProt AC  NX_P55157
Human Synonyms  ABL, MTP
Human Chr (Location)  4q24; chr4:99564083-99623997 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MTTP
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Most embryos homozygous for a reporter allele die at midgestation displaying delayed growth, neurodevelopmental anomalies, impaired erythropoiesis, deficient yolk sac lipoprotein production, hemorrhage and necrosis. Heterozygous mutant mice display altered plasma lipid and lipoprotein profiles.
 
Phenotype Images(1)
Interactions
Mttp interacts with 201 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cholesterol homeostasis, cholesterol metabolic process, ...
Component basolateral plasma membrane, brush border membrane, ...
Function apolipoprotein binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (79)    Tissues (46)    Images (20)
Theiler Stages: 11, 15, 17, 19, 20, 21, 22, 24, 26, 28
Assay TypeResults
RNA in situ 53
Northern blot 1
Western blot 6
RT-PCR 7
RNase protection 12
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(52) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028158 (Evidence)
Entrez Gene17777 (Evidence)
UniGene2941
DFCITC1585247, TC1633183, TC1655427
DoTSDT.103564306, DT.532212, DT.97385622
Consensus CDS ProjectCCDS38650.1, CCDS51080.1
International Mouse Knockout Project StatusMttp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17777 NCBI Gene Model | MGI Sequence Detail 53534 C57BL/6J ±  kb
transcript NM_001163457 RefSeq | MGI Sequence Detail 4272 C57BL/6 
polypeptide O08601 UniProt | EBI | MGI Sequence Detail 894 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(677 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015819 Lipid transport protein, beta-sheet shell
InterPro IPR001747 Lipid transport protein, N-terminal
InterPro IPR015816 Vitellinogen, beta-sheet N-terminal
InterPro IPR011030 Vitellinogen, superhelical
Protein Ontology PR:000003392 microsomal triglyceride transfer protein large subunit
Graphical View of Protein Domain Structure
References (Earliest) J:42428 Knecht TP, et al., The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis. Adv Genet. 1995;32:141-98
(Latest) J:211003 Bjorkegren JL, et al., Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet. 2014 Feb;10(2):e1004201
All references(79)
Other
accession IDs
MGD-MRK-35387, MGI:1917046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory