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Mttp Gene Detail
Summary
  • Symbol
    Mttp
  • Name
    microsomal triglyceride transfer protein
  • Synonyms
    1810043K16Rik, MTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:106926
    NCBI Gene: 17777
Location & Maps
more
  • Sequence Map
    Chr3:138089854-138144968 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55115 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
    Orthology source: HomoloGene
  • Synonyms
    ABL, MTP
  • Links
    NCBI Gene ID: 4547
    neXtProt AC: NX_P55157

  • Chr Location
    4q24; chr4:99564078-99623997 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 212
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MTTP
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human MTTP associations

Human Disease Mouse Models
       Abdominal Obesity-Metabolic Syndrome 1; AOMS1   OMIM: 605552
Abetalipoproteinemia; ABL   OMIM: 200100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Mttp
  • Incidental Mutations
Most embryos homozygous for a reporter allele die at midgestation displaying delayed growth, neurodevelopmental anomalies, impaired erythropoiesis, deficient yolk sac lipoprotein production, hemorrhage and necrosis. Heterozygous mutant mice display altered plasma lipid and lipoprotein profiles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052744 VEGA Gene Model | MGI Sequence Detail 55115 C57BL/6J ±  kb
transcript OTTMUST00000132050 VEGA | MGI Sequence Detail 3072 Not Applicable  
polypeptide OTTMUSP00000070472 VEGA | MGI Sequence Detail 909 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    680 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003392 microsomal triglyceride transfer protein large subunit
  • InterPro Domains
    IPR015819 Lipid transport protein, beta-sheet shell
    IPR001747 Lipid transport protein, N-terminal
    IPR015816 Vitellinogen, beta-sheet N-terminal
    IPR011030 Vitellinogen, superhelical
Molecular
Reagents
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  • All nucleic 54
    cDNA 52
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35387, MGI:1917046
References
more
  • Summaries
    All 84
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 48
  • Earliest
    J:42428 Knecht TP, et al., The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis. Adv Genet. 1995;32:141-98
  • Latest
    J:227102 Wang W, et al., Association between shear stress and platelet-derived transforming growth factor-beta1 release and activation in animal models of aortic valve stenosis. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1924-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory