Gucy2c
Gene Detail

Symbol Name ID

Gucy2c guanylate cyclase 2c MGI:106903

Synonyms

GC-C

Feature Type

protein coding gene

Genetic Map

Chromosome 6

66.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:136697285-136781765 bp, - strand From VEGA annotation of GRCm38   84481 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2c

Human homologs

Human Homolog		GUCY2C, guanylate cyclase 2C (heat stable enterotoxin receptor)
NCBI Gene ID		2984
neXtProt AC		NX_P25092
Human Synonyms		DIAR6, GUC2C, MECIL, MUCIL, STAR
Human Chr (Location)		12p12; chr12:14765566-14849519 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GUCY2C

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice are viable and have an increased resistance to heat-stable enterotoxins.

 
Human Diseases Modeled Using Mouse Gucy2c (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	ATP binding, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (151)    Tissues (117)    Images (12)
Theiler Stages: 20, 22, 23, 28

Assay Type	Results
RNA in situ	112
Northern blot	37
RT-PCR	2

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(18) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033823 (Evidence)
Ensembl Gene Model	ENSMUSG00000042638 (Evidence)
Entrez Gene	14917 (Evidence)
UniGene	222729
DFCI	TC1586408, TC1604883
DoTS	DT.40170647, DT.528822
NIA Mouse Gene Index	U027971
EC	4.6.1.2
Consensus CDS Project	CCDS20653.1, CCDS51941.1
International Mouse Knockout Project Status	Gucy2c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033823	VEGA Gene Model | MGI Sequence Detail	84481	C57BL/6J
transcript	OTTMUST00000085207	VEGA | MGI Sequence Detail	3958	Not Applicable
polypeptide	OTTMUSP00000046000	VEGA | MGI Sequence Detail	1072	Not Applicable

All sequences(31) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(420 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000008352	heat-stable enterotoxin receptor

References

(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:185303 Lin JE, et al., GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One. 2012;7(2):e31686
All references(51)

Other accession IDs

MGD-MRK-35363, MGI:2141513