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Gucy2c
Gene Detail
Symbol

Name
ID
Gucy2c
guanylate cyclase 2c
MGI:106903
Synonyms
GC-C
Feature Type
protein coding gene
Genetic Map
Chromosome 6
66.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:136697285-136781765 bp, - strand
From VEGA annotation of GRCm38

  84481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GUCY2C
Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2c

Human
homologs
GUCY2C, guanylate cyclase 2C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2984
neXtProt AC: NX_P25092

Human Synonyms: DIAR6, GUC2C, MECIL, MUCIL, STAR

Human Chr (Location): 12p12; chr12:14612632-14696618 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GUCY2C

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and have an increased resistance to heat-stable enterotoxins.
 
Interactions
Gucy2c interacts with 147 markers (Mir7-1, Mir10b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (151)    Tissues (117)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
Northern blot 37
RT-PCR 2
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gucy2c    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(18) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033823 (Evidence)
Ensembl Gene Model ENSMUSG00000042638 (Evidence)
Entrez Gene 14917 (Evidence)
UniGene 222729
DFCI TC1586408, TC1604883
DoTS DT.528822, DT.40170647
NIA Mouse Gene Index U027971
EC 4.6.1.2
Consensus CDS Project CCDS20653.1, CCDS51941.1
International Mouse Phenotyping Consortium Status Gucy2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033823 VEGA Gene Model | MGI Sequence Detail 84481 C57BL/6J ±  kb
transcript OTTMUST00000085207 VEGA | MGI Sequence Detail 3958 Not Applicable 
polypeptide OTTMUSP00000046000 VEGA | MGI Sequence Detail 1072 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(1150 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1152)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000008352 heat-stable enterotoxin receptor
References
(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:209706 Harmel-Laws E, et al., Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis. PLoS One. 2013;8(11):e79180
All references(52)
Other
accession IDs
MGD-MRK-35363, MGI:2141513

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory