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Gucy2c
Gene Detail
 Symbol
Name
ID
Gucy2c
guanylate cyclase 2c
MGI:106903
Synonyms GC-C
Feature Type protein coding gene
Genetic Map
Chromosome 6
66.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:136697285-136781765 bp, - strand
From VEGA annotation of GRCm38

  84481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2c

Human
homologs
Human Homolog GUCY2C, guanylate cyclase 2C (heat stable enterotoxin receptor)
NCBI Gene ID 2984
neXtProt AC  NX_P25092
Human Synonyms  DIAR6, GUC2C, MECIL, MUCIL, STAR
Human Chr (Location)  12p12; chr12:14612632-14696585 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GUCY2C
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Homozygous null mice are viable and have an increased resistance to heat-stable enterotoxins.
 
Human Diseases Modeled Using Mouse Gucy2c (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (151)    Tissues (117)    Images (12)
Theiler Stages: 20, 22, 23, 28
Assay TypeResults
RNA in situ 112
Northern blot 37
RT-PCR 2
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(18) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033823 (Evidence)
Ensembl Gene ModelENSMUSG00000042638 (Evidence)
Entrez Gene14917 (Evidence)
UniGene222729
DFCITC1586408, TC1604883
DoTSDT.40170647, DT.528822
NIA Mouse Gene IndexU027971
EC4.6.1.2
Consensus CDS ProjectCCDS20653.1, CCDS51941.1
International Mouse Knockout Project StatusGucy2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033823 VEGA Gene Model | MGI Sequence Detail 84481 C57BL/6J ±  kb
transcript OTTMUST00000085207 VEGA | MGI Sequence Detail 3958 Not Applicable 
polypeptide OTTMUSP00000046000 VEGA | MGI Sequence Detail 1072 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(1150 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1152)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000008352 heat-stable enterotoxin receptor
References (Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:205053 Gibbons AV, et al., Intestinal GUCY2C prevents TGF-beta secretion coordinating desmoplasia and hyperproliferation in colorectal cancer. Cancer Res. 2013 Nov 15;73(22):6654-66
All references(52)
Other
accession IDs
MGD-MRK-35363, MGI:2141513

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory