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Gucy2c Gene Detail
Summary
  • Symbol
    Gucy2c
  • Name
    guanylate cyclase 2c
  • Synonyms
    GC-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:106903
    NCBI Gene: 14917
  • Gene Overview
    MyGene.info: GUCY2C
Location & Maps
more
  • Sequence Map
    Chr6:136697284-136781765 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84482 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 66.67 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GUCY2C, guanylate cyclase 2C
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GUCY2C, guanylate cyclase 2C
    Orthology source: HomoloGene
  • Synonyms
    DIAR6, GUC2C, MECIL, MUCIL, STAR
  • Links
    NCBI Gene ID: 2984
    neXtProt AC: NX_P25092

  • Chr Location
    12p12; chr12:14612632-14696618 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human GUCY2C associations

Human Disease Mouse Models
       Diarrhea 6; DIAR6   OMIM: 614616
Meconium Ileus   OMIM: 614665
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and have an increased resistance to heat-stable enterotoxins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033823 VEGA Gene Model | MGI Sequence Detail 84482 C57BL/6J ±  kb
transcript OTTMUST00000085207 VEGA | MGI Sequence Detail 3959 Not Applicable  
polypeptide OTTMUSP00000046000 VEGA | MGI Sequence Detail 1072 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1128 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008352 heat-stable enterotoxin receptor
  • EC
  • InterPro Domains
    IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
    IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
    IPR029787 Nucleotide cyclase
    IPR028082 Periplasmic binding protein-like I
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001828 Receptor, ligand binding region
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 18
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-35363, MGI:2141513
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
  • Latest
    J:231317 Lin JE, et al., Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis. Cancer Res. 2016 Jan 15;76(2):339-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory