Phenotypes Associated with This Genotype

Genotype
MGI:5300906

• Allelic Composition: Gucy2c^tm1Gar/Gucy2c^tm1Gar
• Genetic Background: B6.129S6-Gucy2c^tm1Gar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased subcutaneous adipose tissue amount ( J:178241 )

increased total body fat amount ( J:178241 )

• mutants exhibit an accumulation of adipose mass, including an increase in visceral and subcutaneous fat compartments

behavior/neurological

increased compensatory feeding amount ( J:178241 )

• fasted and refed mutants display deficient postprandial satiation

polyphagia ( J:178241 )

• mutants are hyperphagic, independent of sex, dietary nutrients, or dietary caloric content

• however, mutants exhibit normal lipid digestion, lipid absorption, distribution and clearance, normal energy mobilization and expenditure, normal circadian cycles and thermoregulatory reflexes to cold, indicating that an increase in caloric consumption is the probable cause of the excess adiposity

cardiovascular system

increased heart weight ( J:178241 )

cardiac hypertrophy ( J:178241 )

• mean heart size in mice raised on either the low calorie or high calorie diet is increased compared to wild-type mice

growth/size/body

increased heart weight ( J:178241 )

cardiac hypertrophy ( J:178241 )

• mean heart size in mice raised on either the low calorie or high calorie diet is increased compared to wild-type mice

increased body weight ( J:178241 )

• mutants raised on a standard low calorie diet, moderate calorie diet, or high calorie diet exhibit an increased body weight compared to wild-type mice

• females raised on the high calorie diet showed the highest weight increase, with mutants being 26.3% heavier than wild-type mice

homeostasis/metabolism

increased circulating insulin level ( J:178241 )

• fasted serum concentrations of 12 months old mutants raised on a high caloric diet are increased compared to wild-type mice on the same diet

increased circulating leptin level ( J:178241 )

• fasted serum leptin levels are increased at 10-12 and 18 months of age in mutants raised on either the low calorie or high calorie diet

impaired glucose tolerance ( J:178241 )

• impaired glycemic control

increased liver triglyceride level ( J:178241 )

• mice raised on a low calorie diet exhibit increased hepatic triglyceride content

integument

increased subcutaneous adipose tissue amount ( J:178241 )

liver/biliary system

increased liver triglyceride level ( J:178241 )

• mice raised on a low calorie diet exhibit increased hepatic triglyceride content

hepatic steatosis ( J:178241 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome		DOID:0060611	OMIM:PS605552	J:178241
obesity		DOID:9970	OMIM:601665	J:178241