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Epcam
Gene Detail
Symbol

Name
ID
Epcam
epithelial cell adhesion molecule
MGI:106653
Synonyms
CD326, EGP-2, Egp314, EpCAM, Ep-CAM, EpCAM1, GA733-2, gp40, Ly74, panepithelial glycoprotein 314, Tacstd1, TROP1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:87635979-87651106 bp, + strand
From Ensembl annotation of GRCm38

  15128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1764  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: epithelial glycoprotein antigen GA733
Gene Tree: Epcam

Human
homologs
Human Homolog EPCAM, epithelial cell adhesion molecule
NCBI Gene ID 4072
neXtProt AC  NX_P16422
Human Synonyms  DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1
Human Chr (Location)  2p21; chr2:47369148-47387028 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human EPCAM
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(9) Targeted(6)
 
Homozygous null mice display embryonic lethality during organogenesis with decreased embryo size, impaired labyrinth layer development and decreased number of trophoblast giant cells. Mice homozygous for another knock-out allele exhibit impaired intestinal tight junctions with lethality.
 
Human Diseases Modeled Using Mouse Epcam (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Epcam interacts with 103 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (33 records)
Data Summary: Results (445)    Tissues (174)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 437
cDNA source data(411)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(413) Genomic(1) cDNA(411) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000045394 (Evidence)
Entrez Gene17075 (Evidence)
UniGene4259
DFCITC1573557
DoTSDT.101124579, DT.101385250, DT.101385252, DT.87072498, DT.94131074
NIA Mouse Gene IndexU018324
Consensus CDS ProjectCCDS29018.1
International Mouse Knockout Project StatusEpcam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045394 Ensembl Gene Model | MGI Sequence Detail 15128 C57BL/6J ±  kb
transcript ENSMUST00000053577 Ensembl | MGI Sequence Detail 2040 Not Applicable 
polypeptide ENSMUSP00000061935 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000001559 epithelial cell adhesion molecule
References
(Earliest) J:10429 Timblin C, et al., Application for PCR technology to subtractive cDNA cloning: identification of genes expressed specifically in murine plasmacytoma cells. Nucleic Acids Res. 1990 Mar 25;18(6):1587-93
(Latest) J:210901 Mueller JL, et al., Functional consequences of EpCam mutation in mice and men. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G278-88
All references(72)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35111, MGD-MRK-35182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory