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Epcam
Gene Detail
Symbol

Name
ID
Epcam
epithelial cell adhesion molecule
MGI:106653
Synonyms
CD326, EGP-2, Egp314, EpCAM, Ep-CAM, EpCAM1, GA733-2, gp40, Ly74, panepithelial glycoprotein 314, Tacstd1, TROP1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
57.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:87635979-87651106 bp, + strand
From Ensembl annotation of GRCm38

  15128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1764  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EPCAM
Protein SuperFamily: epithelial glycoprotein antigen GA733
Gene Tree: Epcam

Human
homologs
EPCAM, epithelial cell adhesion molecule
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4072
neXtProt AC: NX_P16422

Human Synonyms: DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1

Human Chr (Location): 2p21; chr2:47369148-47387028 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human EPCAM

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(9) Targeted(6) Transgenic(1)
Incidental mutations (data from CvDC )
 
Homozygous null mice display embryonic lethality during organogenesis with decreased embryo size, impaired labyrinth layer development and decreased number of trophoblast giant cells. Mice homozygous for another knock-out allele exhibit impaired intestinal tight junctions with lethality.
 
Human Diseases Modeled in Mice Using Epcam (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Epcam interacts with 102 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (36 records)
Data Summary: Results (465)    Tissues (189)    Images (74)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 437
RT-PCR 6
cDNA source data(411)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EPCAM ; Xenbase epcam ; ZFIN epcam    NEW 
Molecular
reagents
All nucleic(414) Genomic(1) cDNA(411) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000045394 (Evidence)
Entrez Gene 17075 (Evidence)
UniGene 4259
DFCI TC1573557
DoTS DT.94131074, DT.87072498, DT.101385252, DT.101385250, DT.101124579
NIA Mouse Gene Index U018324
Consensus CDS Project CCDS29018.1
International Mouse Phenotyping Consortium Status Epcam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045394 Ensembl Gene Model | MGI Sequence Detail 15128 C57BL/6J ±  kb
transcript ENSMUST00000053577 Ensembl | MGI Sequence Detail 2040 Not Applicable 
polypeptide ENSMUSP00000061935 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000001559 epithelial cell adhesion molecule
References
(Earliest) J:10429 Timblin C, et al., Application for PCR technology to subtractive cDNA cloning: identification of genes expressed specifically in murine plasmacytoma cells. Nucleic Acids Res. 1990 Mar 25;18(6):1587-93
(Latest) J:217438 Antas VI, et al., Gastrokine-2 is transiently expressed in the endodermal and endothelial cells of the maturing mouse yolk sac. Gene Expr Patterns. 2014 Nov;16(2):69-74
All references(74)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35111, MGD-MRK-35182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory