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Myo5b
Gene Detail
Symbol

Name
ID
Myo5b
myosin VB
MGI:106598
Feature Type
protein coding gene
Genetic Map
Chromosome 18
50.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr18:74440936-74771493 bp, + strand
From VEGA annotation of GRCm38

  330558 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MYO5B
Gene Tree: Myo5b

Human
homologs
MYO5B, myosin VB
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4645
neXtProt AC: NX_Q9ULV0

Human Chr (Location): 18q21; chr18:49822786-50195081 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYO5B

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Myo5b interacts with 228 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process endosome localization, metabolic process, ...
Component apical cortex, brush border, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (100)    Tissues (52)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myo5b ; ZFIN myo5b    NEW 
Molecular
reagents
All nucleic(53) cDNA(52) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000029560 (Evidence)
Ensembl Gene Model ENSMUSG00000025885 (Evidence)
Entrez Gene 17919 (Evidence)
UniGene 260098
DFCI TC1589259, TC1597431, TC1583892, TC1674612, TC1625430, TC1611756, TC1699038
DoTS DT.40175166, DT.110756887, DT.110756878, DT.101367827, DT.94391489, DT.526952, DT.97394580
NIA Mouse Gene Index U018896
Consensus CDS Project CCDS37858.1
International Mouse Phenotyping Consortium Status Myo5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029560 VEGA Gene Model | MGI Sequence Detail 330558 C57BL/6J ±  kb
transcript OTTMUST00000073304 VEGA | MGI Sequence Detail 6065 Not Applicable 
polypeptide OTTMUSP00000037920 VEGA | MGI Sequence Detail 1844 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(9) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(3382 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018444 Dil domain
InterPro IPR002710 Dilute
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR016038 Thiolase-like, subgroup
Protein Ontology PR:000010866 myosin-Vb
References
(Earliest) J:36578 Huang WM, et al., Molecular cloning and amino acid sequence of brain L-glutamate decarboxylase. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8491-5
(Latest) J:219877 Lv K, et al., Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization. J Neurosci. 2015 Feb 11;35(6):2559-71
All references(46)
Other
accession IDs
MGD-MRK-35054, MGI:2147254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory