Myo5b^tm1.1Cle
Targeted Allele Detail

Summary

• Symbol: Myo5b^tm1.1Cle
• Name: myosin VB; targeted mutation 1.1, Hans Clevers
• MGI ID: MGI:5790962
• Synonyms: Myo5b^fl
• Gene: Myo5b Location: Chr18:74575435-74905769 bp, + strand Genetic Position: Chr18, 50.7 cM
• Alliance: Myo5b^tm1.1Cle page

Microvillus inclusion disease phenotype in Myo5b^tm1.1Cle/Myo5b^tm1.1Cle Tg(Vil1-cre/ERT2)23Syr/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227079
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: LoxP sites were inserted flanking exon 4. An FRT-flanked neomycin resistance cassette was inserted upstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:227079)

Generation of the Myo5b^tm1.1Cle allele

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo5b Mutation: 62 strains or lines available

References

• Original: J:227079 Schneeberger K, et al., An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12408-13
• All: 1 reference(s)