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| Caption | At day 4 after tamoxifen induction, Myo5btm1.1Cle/Myo5btm1.1Cle Tg(Vil1-cre/ERT2)23Syr/0 (Myo5bfl/fl;Vil-CreERT2) mice showed (C) subapical accumulation of PAS-positive vesicles (small arrows) and villus fusion (white arrowheads) and (D) mislocalization of the apical marker alkaline phosphatase (ALP) to the cytoplasm (arrows). (E and F) Transmission electron microscopy (TEM) revealed (E) erosion and loss of apical microvilli (large arrows), subapical accumulation of vesicles (small arrows), intracellular microvillus inclusions (black arrowhead), auto lysosomes (A/Ls), and widened intercellular spaces (*) in villus epithelial cells of Myo5btm1.1Cle/Myo5btm1.1Cle Tg(Vil1-cre/ERT2)23Syr/0 mice. (F) Electron microscopy (EM)-cytochemistry shows epithelial cells at the crypt-villus transition with PAS-positive, classical secretory granules (small arrows). | ||||||
| Copyright | This image is from Schneeberger K, Proc Natl Acad Sci U S A 2015 Oct 6;112(40):12408-13. Copyright 2015 National Academy of Sciences, U.S.A. J:227079 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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