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Hells Gene Detail
Summary
  • Symbol
    Hells
  • Name
    helicase, lymphoid specific
  • Synonyms
    E130115I21Rik, LSH, Lysh, PASG, proliferation-associated SNF2-like, YFK8
  • Feature Type
    protein coding gene
  • IDs
    MGI:106209
    NCBI Gene: 15201
  • Gene Overview
    MyGene.info: HELLS
Location & Maps
more
  • Sequence Map
    Chr19:38930915-38971051 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40137 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 33.57 cM, cytoband C3-D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HELLS, helicase, lymphoid-specific
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HELLS, helicase, lymphoid-specific
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ICF4, LSH, Nbla10143, PASG, SMARCA6
  • Links
    NCBI Gene ID: 3070
    neXtProt AC: NX_Q9NRZ9

  • Chr Location
    10q24.2; chr10:94545767-94602099 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HELLS associations

Human Disease Mouse Models
       Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 4; ICF4   OMIM: 616911
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show DNA hypomethylation, delayed growth, multiorgan and skeletal defects, premature graying, alopecia, low fat deposition, kyphosis, cachexia and early death. Homozygotes for another null allele show neonatal death, low birth weight, lymphoid defects and renal lesions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021232 VEGA Gene Model | MGI Sequence Detail 40137 C57BL/6J ±  kb
transcript OTTMUST00000050285 VEGA | MGI Sequence Detail 5868 Not Applicable  
polypeptide OTTMUSP00000023455 VEGA | MGI Sequence Detail 821 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    101 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029539 lymphoid-specific helicase
  • EC
  • InterPro Domains
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000330 SNF2-related, N-terminal domain
Molecular
Reagents
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  • All nucleic 22
    Genomic 5
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-33900, MGD-MRK-33901, MGI:106208, MGI:1925121, MGI:2147507
References
more
  • Summaries
    All 55
    Developmental Gene Expression 9
    Gene Ontology 10
    Phenotypes 19
  • Earliest
    J:32111 Jarvis CD, et al., A novel putative helicase produced in early murine lymphocytes. Gene. 1996 Mar 9;169(2):203-7
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory