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Hells
Gene Detail
 Symbol
Name
ID
Hells
helicase, lymphoid specific
MGI:106209
Synonyms E130115I21Rik, LSH, Lysh, PASG, proliferation-associated SNF2-like, YFK8
Feature Type protein coding gene
Genetic Map
Chromosome 19
33.57 cM, cytoband C3-D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:38930915-38971051 bp, + strand
From VEGA annotation of GRCm38

  40137 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:50037  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Hells

Human
homologs
Human Homolog HELLS, helicase, lymphoid-specific
NCBI Gene ID 3070
neXtProt AC  NX_Q9NRZ9
Human Synonyms  LSH, PASG, SMARCA6
Human Chr (Location)  10q24.2; chr10:94545767-94602871 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(59) : Gene trapped(53) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show DNA hypomethylation, delayed growth, multiorgan and skeletal defects, premature graying, alopecia, low fat deposition, kyphosis, cachexia and early death. Homozygotes for another null allele show neonatal death, low birth weight, lymphoid defects and renal lesions.
 
Interactions
Hells interacts with 358 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell cycle, cell division, ...
Component chromosome, centromeric region, nucleus, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (33)    Images (12)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 16
Northern blot 16
RT-PCR 14
cDNA source data(12)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(5) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021232 (Evidence)
Ensembl Gene ModelENSMUSG00000025001 (Evidence)
Entrez Gene15201 (Evidence)
DFCITC1575339, TC1605226
DoTSDT.530501, DT.94132752
NIA Mouse Gene IndexU043725, U356990
EC3.6.4.-
Consensus CDS ProjectCCDS29789.1
International Mouse Knockout Project StatusHells
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021232 VEGA Gene Model | MGI Sequence Detail 40137 C57BL/6J ±  kb
transcript OTTMUST00000050285 VEGA | MGI Sequence Detail 5868 Not Applicable 
polypeptide OTTMUSP00000023455 VEGA | MGI Sequence Detail 821 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000330 SNF2-related
Protein Ontology PR:000029539 lymphoid-specific helicase
References (Earliest) J:32111 Jarvis CD, et al., A novel putative helicase produced in early murine lymphocytes. Gene. 1996 Mar 9;169(2):203-7
(Latest) J:208860 Yu W, et al., CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5890-5
All references(56)
Other
accession IDs
MGD-MRK-33900, MGD-MRK-33901, MGI:106208, MGI:1925121, MGI:2147507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory