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Hells Gene Detail
Summary
  • Symbol
    Hells
  • Name
    helicase, lymphoid specific
  • Synonyms
    E130115I21Rik, LSH, Lysh, PASG, proliferation-associated SNF2-like, YFK8
  • Feature Type
    protein coding gene
  • IDs
    MGI:106209
    NCBI Gene: 15201
  • Gene Overview
    MyGene.info: HELLS
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38930990-38970470 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 33.57 cM, cytoband C3-D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106209
protein coding gene Chr19:38930915-38971051 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025096
protein coding gene Chr19:38038578-38084354 (+)
A/J MGP_AJ_G0025072
protein coding gene Chr19:36183232-36229435 (+)
AKR/J MGP_AKRJ_G0025040
protein coding gene Chr19:37384416-37425311 (+)
BALB/cJ MGP_BALBcJ_G0025070
protein coding gene Chr19:36280218-36320951 (+)
C3H/HeJ MGP_C3HHeJ_G0024829
protein coding gene Chr19:37495209-37540998 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025511
protein coding gene Chr19:39099538-39143816 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022930
protein coding gene Chr19:35493046-35532834 (+)
CAST/EiJ MGP_CASTEiJ_G0024296
protein coding gene Chr19:37360662-37404747 (+)
CBA/J MGP_CBAJ_G0024806
protein coding gene Chr19:40968707-41015988 (+)
DBA/2J MGP_DBA2J_G0024938
protein coding gene Chr19:36017838-36059634 (+)
FVB/NJ MGP_FVBNJ_G0024899
protein coding gene Chr19:35845762-35888973 (+)
LP/J MGP_LPJ_G0025024
protein coding gene Chr19:38108210-38148754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024930
protein coding gene Chr19:40675867-40732117 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025569
protein coding gene Chr19:37512892-37552872 (+)
PWK/PhJ MGP_PWKPhJ_G0024048
protein coding gene Chr19:35893436-35935409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023848
protein coding gene Chr19:36340343-36381274 (+)
WSB/EiJ MGP_WSBEiJ_G0024363
protein coding gene Chr19:37595630-37639607 (+)



Homology
more
  • Human Ortholog
    HELLS, helicase, lymphoid specific
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HELLS, helicase, lymphoid specific
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ICF4, LSH, Nbla10143, PASG, SMARCA6
  • Links
    NCBI Gene ID: 3070
    neXtProt AC: NX_Q9NRZ9
    UniProt: Q9NRZ9

  • Chr Location
    10q23.33; chr10:94545767-94613905 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HELLS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 4 alleles in 5 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show DNA hypomethylation, delayed growth, multiorgan and skeletal defects, premature graying, alopecia, low fat deposition, kyphosis, cachexia and early death. Homozygotes for another null allele show neonatal death, low birth weight, lymphoid defects and renal lesions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15201 NCBI Gene Model | MGI Sequence Detail 39481 C57BL/6J ±  kb
    transcript NM_008234 RefSeq | MGI Sequence Detail 3039 C57BL/6  
    polypeptide Q60848 UniProt | EBI | MGI Sequence Detail 821 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR001650 Helicase, C-terminal
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR038718 SNF2-like, N-terminal domain superfamily
      IPR000330 SNF2-related, N-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 5
      cDNA 16
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33900, MGD-MRK-33901, MGI:106208, MGI:1925121, MGI:2147507
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:32111 Jarvis CD, et al., A novel putative helicase produced in early murine lymphocytes. Gene. 1996 Mar 9;169(2):203-7
    • Latest
      J:247213 Termanis A, et al., The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells. Nucleic Acids Res. 2016 Sep 19;44(16):7592-604

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory