Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chromatin binding activity. Involved in kidney development; lymphocyte proliferation; and negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including DNA methylation; cellular response to leukemia inhibitory factor; and negative regulation of intrinsic apoptotic signaling pathway. Located in chromosome, centromeric region and nucleus. Part of pericentric heterochromatin. Is expressed in several structures, including gut; hippocampus; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).