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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hells
helicase, lymphoid specific
MGI:106209
64 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hellstm1a(EUCOMM)Wtsi/Hellstm1a(EUCOMM)Wtsi
C57BL/6N-Hellstm1a(EUCOMM)Wtsi/Ieg 		abnormal gait J:165965
decreased body weight J:165965
decreased circulating cholesterol level J:165965
decreased circulating LDL cholesterol level J:165965
decreased circulating triglyceride level J:165965
decreased granulocyte number J:165965
decreased IgG1 level J:165965
Hellstm1b(EUCOMM)Wtsi/Hells+
C57BL/6N-Hellstm1b(EUCOMM)Wtsi/Ieg 		decreased heart rate J:211773
dilated heart left ventricle J:211773
increased cardiac stroke volume J:211773
Hellstm1b(EUCOMM)Wtsi/Hellstm1b(EUCOMM)Wtsi
C57BL/6N-Hellstm1b(EUCOMM)Wtsi/Ieg 		preweaning lethality, complete penetrance J:211773
Hellstm1c(EUCOMM)Wtsi/Hellstm1d(EUCOMM)Wtsi
Tg(Stra8-icre)1Reb/0
(B6(Cg)-Hellstm1c(EUCOMM)Wtsi/BakrJ x B6.Cg-Hellstm1d(EUCOMM)Wtsi Tg(Stra8-icre)1Reb/Bakr)F1 		abnormal DNA methylation J:283594
abnormal DNA methylation during gametogenesis J:283594
abnormal meiosis J:283594
arrest of male meiosis J:283594
decreased male germ cell number J:283594
decreased testis weight J:283594
increased male germ cell apoptosis J:283594
male infertility J:283594
Hellstm1Kmu/Hellstm1Kmu
involves: 129S1/Sv 		abnormal chromosome morphology J:72618
abnormal kidney morphology J:76112
abnormal proximal convoluted tubule morphology J:76112
decreased B cell number J:61948
decreased body weight J:76112
dilated renal tubule J:76112
increased CD8-positive, alpha-beta T cell number J:61948
increased double-negative T cell number J:61948
increased renal tubule apoptosis J:76112
neonatal lethality, complete penetrance J:76112
renal tubular necrosis J:76112
small spleen J:61948
small thymus J:61948
Hellstm1Kmu/Hellstm1Kmu
involves: 129S/SvEv * CZECHII/EiJ 		paternal imprinting J:96925
Hellstm1Rarc/Hellstm1Rarc
involves: 129X1/SvJ * C57BL/6J 		abnormal axial skeleton morphology J:107145
abnormal chromosome number J:107145
abnormal coat/hair pigmentation J:107145
abnormal gait J:107145
abnormal kidney morphology J:107145
abnormal long bone epiphysis morphology J:107145
abnormal long bone morphology J:107145
abnormal renal tubule morphology J:107145
abnormal thoracic vertebrae morphology J:107145
abnormal tibia morphology J:107145
alopecia J:107145
atelectasis J:107145
cachexia J:107145
decreased birth weight J:107145
decreased body weight J:107145
decreased bone mineral density J:107145
decreased cell proliferation J:107145
decreased cellular sensitivity to gamma-irradiation J:107145
decreased embryo weight J:107145
decreased fetal weight J:107145
decreased subcutaneous adipose tissue amount J:107145
delayed bone ossification J:107145
delayed endochondral bone ossification J:107145
dilated renal tubule J:107145
hyperkeratosis J:107145
hypoglycemia J:107145
kyphosis J:107145
osteoporosis J:107145
perinatal lethality, incomplete penetrance J:107145
postnatal lethality, incomplete penetrance J:107145
premature aging J:107145
respiratory failure J:107145
short femur J:107145
short tibia J:107145
small kidney J:107145
small thymus J:107145
thymus hypoplasia J:107145
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory