About   Help   FAQ
Nrp1
Gene Detail
Symbol

Name
ID
Nrp1
neuropilin 1
MGI:106206
Synonyms
Neuropilin-1, NP-1, Npn1, NPN-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
75.78 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:128359073-128505462 bp, + strand
From Ensembl annotation of GRCm38

  146390 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NRP1
Protein SuperFamily: neuropilin
Gene Tree: Nrp1

Human
homologs
NRP1, neuropilin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8829
neXtProt AC: NX_O14786

Human Synonyms: BDCA4, CD304, NP1, NRP, VEGF165R

Human Chr (Location): 10p12; chr10:33177491-33334905 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice show embryonic death, impaired neuronal migration and axon guidance, and vascular defects including a disorganized yolk sac vascular plexus, and malformed brachial arch arteries and great vessels. Mice lacking the cytoplasmic domain show altered retinal arteriovenous patterning.
 
Interactions
Nrp1 interacts with 388 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (123 annotations)
Process angiogenesis, angiogenesis involved in coronary vascular morphogenesis, ...
Component axon, cell surface, ...
Function growth factor binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (185 records)
Data Summary: Results (294)    Tissues (201)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 104
RNA in situ 162
Western blot 7
RT-PCR 21
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NRP1 ; Xenbase nrp1 ; ZFIN nrp1a, nrp1b    NEW 
Molecular
reagents
All nucleic(35) Genomic(1) cDNA(26) Primer pair(5) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000025810 (Evidence)
Entrez Gene 18186 (Evidence)
DFCI TC1575043, TC1587693, TC1600256, TC1605896, TC1627472
DoTS DT.101359634, DT.101715408, DT.101738364, DT.87068938, DT.99844648, DT.99852123
NIA Mouse Gene Index U009993
PDB 4GZ9, 4GZA
Consensus CDS Project CCDS22790.1
International Mouse Phenotyping Consortium Status Nrp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025810 Ensembl Gene Model | MGI Sequence Detail 146390 C57BL/6J ±  kb
transcript ENSMUST00000026917 Ensembl | MGI Sequence Detail 5907 Not Applicable 
polypeptide ENSMUSP00000026917 Ensembl | MGI Sequence Detail 923 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(957 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000859 CUB domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000998 MAM domain
InterPro IPR014648 Neuropilin
InterPro IPR027146 Neuropilin-1
InterPro IPR022579 Neuropilin-1, C-terminal
Protein Ontology PR:000001900 neuropilin-1
References
(Earliest) J:30346 Kitsukawa T, et al., Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development. 1995 Dec;121(12):4309-18
(Latest) J:221787 Arbeille E, et al., Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366
All references(274)
Other
accession IDs
MGD-MRK-33897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory