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Nrp1 Gene Detail
Summary
  • Symbol
    Nrp1
  • Name
    neuropilin 1
  • Synonyms
    Neuropilin-1, NP-1, Npn1, NPN-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106206
    NCBI Gene: 18186
  • Gene Overview
    MyGene.info: NRP1
Location & Maps
more
  • Sequence Map
    Chr8:128359073-128505462 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      146390 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NRP1, neuropilin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NRP1, neuropilin 1
    Orthology source: HomoloGene
  • Synonyms
    BDCA4, CD304, NP1, NRP, VEGF165R
  • Links
    NCBI Gene ID: 8829
    neXtProt AC: NX_O14786

  • Chr Location
    10p12; chr10:33177491-33334905 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2876
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NRP1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 6 alleles in 11 genetic backgrounds
    10 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice show embryonic death, impaired neuronal migration and axon guidance, and vascular defects including a disorganized yolk sac vascular plexus, and malformed brachial arch arteries and great vessels. Mice lacking the cytoplasmic domain show altered retinal arteriovenous patterning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025810 Ensembl Gene Model | MGI Sequence Detail 146390 C57BL/6J ±  kb
transcript ENSMUST00000026917 Ensembl | MGI Sequence Detail 5907 Not Applicable  
polypeptide ENSMUSP00000026917 Ensembl | MGI Sequence Detail 923 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    957 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
less
  • All nucleic 37
    Genomic 1
    cDNA 27
    Primer pair 6
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33897
References
more
  • Summaries
    All 284
    Developmental Gene Expression 193
    Gene Ontology 32
    Phenotypes 80
  • Earliest
    J:30346 Kitsukawa T, et al., Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development. 1995 Dec;121(12):4309-18
  • Latest
    J:226996 Ge X, et al., Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory