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Ppm1g
Gene Detail
Symbol

Name
ID
Ppm1g
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
MGI:106065
Synonyms
Fin13
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:31202668-31220545 bp, - strand
From NCBI annotation of GRCm38

  17878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31106  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPM1G
Gene Tree: Ppm1g

Human
homologs
PPM1G, protein phosphatase, Mg2+/Mn2+ dependent, 1G
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5496
neXtProt AC: NX_O15355

Human Synonyms: PP2CG, PP2CGAMMA, PPP2CG

Human Chr (Location): 2p23.3; chr2:27381199-27409683 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(14) Radiation induced(3) Targeted(3)
Genomic Mutations involving Ppm1g (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display perinatal lethality. Mice heterozygous for a targeted mutation display a decrease in prepulse inhibition.
 
Human Diseases Modeled in Mice Using Ppm1g (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Ppm1g interacts with 107 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, cell cycle arrest, ...
Component nucleoplasm, nucleus
Function catalytic activity, cation binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (231)    Tissues (135)    Images (82)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
In situ reporter (knock in) 127
Northern blot 17
RT-PCR 84
cDNA source data(187)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppm1g ; ZFIN ppm1g    NEW 
Molecular
reagents
All nucleic(190) Genomic(1) cDNA(187) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029147 (Evidence)
Entrez Gene 14208 (Evidence)
UniGene 14501
DFCI TC1574113
DoTS DT.493358
NIA Mouse Gene Index U026064
EC 3.1.3.16
Consensus CDS Project CCDS19179.1
International Mouse Phenotyping Consortium Status Ppm1g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14208 NCBI Gene Model | MGI Sequence Detail 17878 C57BL/6J ±  kb
transcript NM_008014 RefSeq | MGI Sequence Detail 2165 C57BL/6 
polypeptide Q61074 UniProt | EBI | MGI Sequence Detail 542 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
Protein Ontology PR:000013095 protein phosphatase 1G
Graphical View of Protein Domain Structure
References
(Earliest) J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
(Latest) J:199575 Foster WH, et al., Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn. 2013 Sep;242(9):1101-9
All references(35)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33749, MGI:2140851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory