Ppm1g
Gene Detail

Symbol Name ID

Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform MGI:106065

Synonyms

Fin13

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:31202668-31220545 bp, - strand From NCBI annotation of GRCm38   17878 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ppm1g ± 2 cM)

Gene Tree: Ppm1g

Human ortholog

PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G NCBI Gene ID 5496
Human Synonyms: PP2CG, PP2CGAMMA, PPP2CG
Human Chr2:27604061-27632496 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(17) : Targeted(3) Gene trapped(14)
 

Mice homozygous for a targeted mutation display perinatal lethality. Mice heterozygous for a targeted mutation display a decrease in prepulse inhibition.

 
Human Diseases Modeled Using Mouse Ppm1g (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	nucleus
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (231)    Tissues (136)    Images (82)
Theiler Stages: 17, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	3
In situ reporter (knock in)	127
Northern blot	17
RT-PCR	84

cDNA source data(186)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(189) Genomic(1) cDNA(186) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000029147 (Evidence)
Entrez Gene	14208 (Evidence)
UniGene	14501
DFCI	TC1574113
DoTS	DT.493358
NIA Mouse Gene Index	U026064
EC	3.1.3.16
Consensus CDS Project	CCDS19179.1
International Mouse Knockout Project Status	Ppm1g

Sequences

Length	Strain/Species
genomic	14208	NCBI Gene Model | MGI Sequence Detail	17878	C57BL/6J
transcript	NM_008014	RefSeq | MGI Sequence Detail	2165	C57BL/6
polypeptide	Q61074	UniProt | EBI | MGI Sequence Detail	542	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015655	Protein phosphatase 2C
InterPro	IPR001932	Protein phosphatase 2C-like
InterPro	IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site
Protein Ontology	PR:000013095	protein phosphatase 1G

Graphical View of Protein Domain Structure

References

(Earliest) J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
(Latest) J:149737 Sansom SN, et al., The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
All references(34)

Other accession IDs

MGD-MRK-33749, MGI:2140851