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Ppm1g Gene Detail
Summary
  • Symbol
    Ppm1g
  • Name
    protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
  • Synonyms
    Fin13
  • Feature Type
    protein coding gene
  • IDs
    MGI:106065
    NCBI Gene: 14208
  • Gene Overview
    MyGene.info: PPM1G
Location & Maps
more
  • Sequence Map
    Chr5:31202664-31220687 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18024 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPM1G, protein phosphatase, Mg2+/Mn2+ dependent 1G
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPM1G, protein phosphatase, Mg2+/Mn2+ dependent 1G
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP2CG, PP2CGAMMA, PPP2CG
  • Links
    NCBI Gene ID: 5496
    neXtProt AC: NX_O15355

  • Chr Location
    2p23.3; chr2:27381199-27409683 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31106
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PPM1G
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ppm1g mouse models

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Gene trapped
    14
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Ppm1g
  • Incidental Mutations
Mice homozygous for a targeted mutation display perinatal lethality. Mice heterozygous for a targeted mutation display a decrease in prepulse inhibition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055347 VEGA Gene Model | MGI Sequence Detail 18024 C57BL/6J ±  kb
transcript OTTMUST00000137018 VEGA | MGI Sequence Detail 2307 Not Applicable  
polypeptide OTTMUSP00000072215 VEGA | MGI Sequence Detail 542 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 190
    Genomic 1
    cDNA 187
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33749, MGI:2140851
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
  • Latest
    J:199575 Foster WH, et al., Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn. 2013 Sep;242(9):1101-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory