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Ednra
Gene Detail
Symbol

Name
ID
Ednra
endothelin receptor type A
MGI:105923
Synonyms
ETa, ET-AR, Gpcr10
Feature Type
protein coding gene
Genetic Map
Chromosome 8
36.63 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:77663031-77724464 bp, - strand
From VEGA annotation of GRCm38

  61434 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EDNRA
Protein SuperFamily: endothelin receptor
Gene Tree: Ednra

Human
homologs
EDNRA, endothelin receptor type A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1909
neXtProt AC: NX_P25101

Human Synonyms: ETA, ET-A, ETAR, ETA-R, ETRA, hET-AR, MFDA

Human Chr (Location): 4q31.22; chr4:147480917-147544954 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human EDNRA

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes perinatal lethality and craniofacial deformities including middle ear defects. Homozygotes for a null allele also show severe cardiac outflow and great vessel anomalies, respiratory and PNS defects, thymus and tongue hypoplasia, and absent salivary glands.
 
Human Diseases Modeled in Mice Using Ednra (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ednra interacts with 263 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (28 records)
Data Summary: Results (142)    Tissues (75)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
In situ reporter (knock in) 40
Northern blot 13
RT-PCR 16
cDNA source data(14)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase ednra ; ZFIN ednraa, ednrab    NEW 
Molecular
reagents
All nucleic(21) cDNA(16) Primer pair(1) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000024406 (Evidence)
Ensembl Gene Model ENSMUSG00000031616 (Evidence)
Entrez Gene 13617 (Evidence)
DFCI TC1596479, TC1577235, TC1621951, TC1624720
DoTS DT.101287404, DT.55143548, DT.484376, DT.40143707
NIA Mouse Gene Index U029984, U029983
Consensus CDS Project CCDS22427.1
International Mouse Phenotyping Consortium Status Ednra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024406 VEGA Gene Model | MGI Sequence Detail 61434 C57BL/6J ±  kb
transcript OTTMUST00000059825 VEGA | MGI Sequence Detail 3625 Not Applicable 
polypeptide OTTMUSP00000029132 VEGA | MGI Sequence Detail 427 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(557 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002175 Endothelin receptor A
InterPro IPR000499 Endothelin receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001221 endothelin-1 receptor
References
(Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:216371 Lehmann LH, et al., Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504
All references(82)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16350, MGD-MRK-33601, MGI:99570

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory