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Ednra
Gene Detail
 Symbol
Name
ID
Ednra
endothelin receptor type A
MGI:105923
Synonyms ETa, ET-AR, Gpcr10
Feature Type protein coding gene
Genetic Map
Chromosome 8
36.63 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:77663031-77724464 bp, - strand
From VEGA annotation of GRCm38

  61434 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: endothelin receptor
Gene Tree: Ednra

Human
homologs
Human Homolog EDNRA, endothelin receptor type A
NCBI Gene ID 1909
neXtProt AC  NX_P25101
Human Synonyms  ETA, ET-A, ETAR, ETA-R, ETRA, hET-AR
Human Chr (Location)  4q31.22; chr4:147480917-147544954 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EDNRA
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes perinatal lethality and craniofacial deformities including middle ear defects. Homozygotes for a null allele also show severe cardiac outflow and great vessel anomalies, respiratory and PNS defects, thymus and tongue hypoplasia, and absent salivary glands.
 
Human Diseases Modeled Using Mouse Ednra (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ednra interacts with 264 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process artery smooth muscle contraction, cellular response to mechanical stimulus, ...
Component cytosol, integral component of membrane, ...
Function endothelin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (142)    Tissues (75)    Images (44)
Theiler Stages: 13, 15, 18, 19, 20, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 73
In situ reporter (knock in) 40
Northern blot 13
RT-PCR 16
cDNA source data(14)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(16) Primer pair(1) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024406 (Evidence)
Ensembl Gene ModelENSMUSG00000031616 (Evidence)
Entrez Gene13617 (Evidence)
DFCITC1577235, TC1596479, TC1621951, TC1624720
DoTSDT.101287404, DT.40143707, DT.484376, DT.55143548
NIA Mouse Gene IndexU029983, U029984
Consensus CDS ProjectCCDS22427.1
International Mouse Knockout Project StatusEdnra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024406 VEGA Gene Model | MGI Sequence Detail 61434 C57BL/6J ±  kb
transcript OTTMUST00000059825 VEGA | MGI Sequence Detail 3625 Not Applicable 
polypeptide OTTMUSP00000029132 VEGA | MGI Sequence Detail 427 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(557 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002175 Endothelin receptor A
InterPro IPR000499 Endothelin receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001221 endothelin-1 receptor
References (Earliest) J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
(Latest) J:204461 Kim KS, et al., Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms. Mech Dev. 2013 Nov-Dec;130(11-12):553-66
All references(81)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16350, MGD-MRK-33601, MGI:99570

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory