Ednra^tm1Ywa
Targeted Allele Detail

Summary

• Symbol: Ednra^tm1Ywa
• Name: endothelin receptor type A; targeted mutation 1, Masashi Yanagisawa
• MGI ID: MGI:1857473
• Synonyms: ET/A -
• Gene: Ednra Location: Chr8:78389658-78451081 bp, - strand Genetic Position: Chr8, 36.63 cM, cytoband C2
• Alliance: Ednra^tm1Ywa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46639
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 5 and 6, which encode the sixth and seventh transmembrane domains of the protein. Radioligand binding assays on samples derived from skin of homozygous embryos demonstrated that no functional protein was produced from this allele. (J:46639)

Disease models

Expression

In Mice Carrying this Mutation:	153 assay results
In Structures Affected by this Mutation:	47 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ednra Mutation: 34 strains or lines available

References

• Original: J:46639 Clouthier DE, et al., Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development. 1998 Mar;125(5):813-24
• All: 16 reference(s)