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Gucy2e
Gene Detail
Symbol

Name
ID
Gucy2e
guanylate cyclase 2e
MGI:105123
Synonyms
GC1, GC-E, ROS-GC1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:69218120-69237036 bp, - strand
From VEGA annotation of GRCm38

  18917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2e

Human
homologs
Human Homolog GUCY2D, guanylate cyclase 2D, membrane (retina-specific)
NCBI Gene ID 3000
neXtProt AC  NX_Q02846
Human Synonyms  CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RCD2, retGC, RETGC-1, ROSGC, ROS-GC1
Human Chr (Location)  17p13.1; chr17:8002670-8020340 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GUCY2D
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal retinal cone cell morphology, impaired cone and rod electrophysiology, and severe retinal cone cell degeneration.
 
Human Diseases Modeled Using Mouse Gucy2e (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Gucy2e interacts with 419 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component integral component of membrane, membrane, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (98)    Tissues (97)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
RT-PCR 2
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(24) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005963 (Evidence)
Ensembl Gene ModelENSMUSG00000020890 (Evidence)
Entrez Gene14919 (Evidence)
UniGene291816
DFCITC1590014, TC1597284, TC1599159
DoTSDT.101721044, DT.101723390, DT.91435578
NIA Mouse Gene IndexU032955
EC4.6.1.2
Consensus CDS ProjectCCDS24887.1
International Mouse Knockout Project StatusGucy2e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005963 VEGA Gene Model | MGI Sequence Detail 18917 C57BL/6J ±  kb
transcript OTTMUST00000013316 VEGA | MGI Sequence Detail 3645 Not Applicable 
polypeptide OTTMUSP00000006167 VEGA | MGI Sequence Detail 1108 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(318 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR011645 Haem NO binding associated
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000008353 retinal guanylyl cyclase 1
References
(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:207409 Ma H, et al., Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3602-7
All references(46)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-32164, MGI:3528170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory