Gucy2e
Gene Detail

Symbol Name ID

Gucy2e guanylate cyclase 2e MGI:105123

Synonyms

GC1, GC-E, ROS-GC1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:69218120-69237036 bp, - strand From VEGA annotation of GRCm38   18917 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2e

Human homologs

Human Homolog		GUCY2D, guanylate cyclase 2D, membrane (retina-specific)
NCBI Gene ID		3000
neXtProt AC		NX_Q02846
Human Synonyms		CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RCD2, retGC, RETGC-1, ROSGC, ROS-GC1
Human Chr (Location)		17p13.1; chr17:7905988-7923658 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GUCY2D

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit abnormal retinal cone cell morphology, impaired cone and rod electrophysiology, and severe retinal cone cell degeneration.

 
Human Diseases Modeled Using Mouse Gucy2e (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component	integral to membrane, membrane, ...
Function	ATP binding, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (98)    Tissues (97)    Images (3)
Theiler Stages: 20, 22, 28

Assay Type	Results
RNA in situ	96
RT-PCR	2

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(2) cDNA(24) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005963 (Evidence)
Ensembl Gene Model	ENSMUSG00000020890 (Evidence)
Entrez Gene	14919 (Evidence)
UniGene	291816
DFCI	TC1590014, TC1597284, TC1599159
DoTS	DT.101721044, DT.101723390, DT.91435578
NIA Mouse Gene Index	U032955
EC	4.6.1.2
Consensus CDS Project	CCDS24887.1
International Mouse Knockout Project Status	Gucy2e

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005963	VEGA Gene Model | MGI Sequence Detail	18917	C57BL/6J
transcript	OTTMUST00000013316	VEGA | MGI Sequence Detail	3645	Not Applicable
polypeptide	OTTMUSP00000006167	VEGA | MGI Sequence Detail	1108	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR011645	Haem NO binding associated
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000008353	retinal guanylyl cyclase 1

References

(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:194571 West EL, et al., Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells. 2012 Jul;30(7):1424-35
All references(43)

Other accession IDs

MGD-MRK-32164, MGI:3528170