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Targeted Allele Detail
Symbol: Gucy2ftm1Wbae
Name: guanylate cyclase 2f; targeted mutation 1, Wolfgang Baehr
MGI ID: MGI:3709985
Synonyms: GC2-, RetGC2-
Gene: Gucy2f  Location: ChrX:140864156-140979927 bp, - strand  Genetic Position: ChrX, 62.85 cM
Alliance: Gucy2ftm1Wbae page
Abnormal rod outer segments in Gucy2etm1Gar/Gucy2etm1Gar Gucy2ftm1Wbae/Gucy2ftm1Wbae mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:120903
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the ATG and peptide leader sequence encoded by exon 2. Immunoblot confirmed absence of protein in mutant retinal lysates. (J:120903)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gucy2f Mutation:  5 strains or lines available
Original:  J:120903 Baehr W, et al., The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem. 2007 Mar 23;282(12):8837-47
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory