Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2ftm1Wbae mutation
(0 available);
any
Gucy2f mutation
(4 available)
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vision/eye
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• a-wave amplitude and sensitivity of scotopic response are reduced at high flash stimulus intensities
• after exposure to high intensity light, followed by 1 hour of dark adaptation, a-wave amplitude recovery is delayed relative to wild-type, with only 50% recovery
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2etm1Gar mutation
(1 available);
any
Gucy2e mutation
(45 available)
Gucy2ftm1Wbae mutation
(0 available);
any
Gucy2f mutation
(4 available)
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Abnormal rod outer segments in Gucy2etm1Gar/Gucy2etm1Gar Gucy2ftm1Wbae/Gucy2ftm1Wbae mice
vision/eye
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• retinas have slightly decreased cone numbers relative to controls
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• at 2 months of age, outer segment lengths are ~50-70% of normal
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• cone cell remnants are identified in the retina, but outer segments are absent
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• cone degeneration is most severe inferior to the optic nerve
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• complete lack of cGMP
• rods are surrounded by blebs in interphotoreceptor matrix
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• at 6 months of age, rod outer segments are severely reduced in superior/inferior and nasal/temporal quadrants
• in retina, rod outer segments are shorter and narrower than in wild-type, and appear banded by alternating regions of dense membrane layers and lumen-containing tubules
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• at 6 months of age, outer nuclear layer (ONL) contains only 4-6 rows of nuclei
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• scotopic electroretinographic responses are absent in all double homozygotes
• no detectable light-sensitive current is detectable in rods
• after exposure to high intensity light, followed by 1 hour of dark adaptation, a-wave amplitude recovery is completely absent in mutants compared to 70% recovery in wild-type
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nervous system
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• retinas have slightly decreased cone numbers relative to controls
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• at 2 months of age, outer segment lengths are ~50-70% of normal
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• cone cell remnants are identified in the retina, but outer segments are absent
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• cone degeneration is most severe inferior to the optic nerve
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• complete lack of cGMP
• rods are surrounded by blebs in interphotoreceptor matrix
|
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• at 6 months of age, rod outer segments are severely reduced in superior/inferior and nasal/temporal quadrants
• in retina, rod outer segments are shorter and narrower than in wild-type, and appear banded by alternating regions of dense membrane layers and lumen-containing tubules
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