About   Help   FAQ
Targeted Allele Detail
Symbol: Nrltm1Asw
Name: neural retina leucine zipper gene; targeted mutation 1, Anand Swaroop
MGI ID: MGI:2152376
Synonyms: cone-full, Nrl-
Gene: Nrl  Location: Chr14:55756435-55762438 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Nrltm1Asw page
Adult rods are reprogrammed into cone-like cells in Nrltm1.1Jcco/Nrltm1.1Jcco and Nrltm1Asw/Nrltm1Asw retinas

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:71808
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced the entire coding region (exons 2 and 3). Immunoblot analysis did not detect protein in retina from 10 day old homozygous mutant mice. RT-PCR studies of retina from 10 day old homozygous mutant mice did not detect mRNA. (J:78692)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 52119 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrl Mutation:  14 strains or lines available
Original:  J:71808 Swain PK, et al., Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. J Biol Chem. 2001 Sep 28;276(39):36824-30
All:  118 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory