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E2f5
Gene Detail
Symbol

Name
ID
E2f5
E2F transcription factor 5
MGI:105091
Synonyms
E2F-5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
3.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:14578641-14606309 bp, + strand
From VEGA annotation of GRCm38

  27669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1472  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: E2F5
Protein SuperFamily: transcription factor E2F
Gene Tree: E2f5

Human
homologs
E2F5, E2F transcription factor 5, p130-binding
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1875
neXtProt AC: NX_Q15329

Human Synonyms: E2F-5

Human Chr (Location): 8q21.2; chr8:85177056-85214518 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop non-obstructive hydrocephalus, ruffled coats, ataxic gait, and dehydration after weaning and die prematurely at an average age of 6 weeks. They exhibit dilated ventricles and cerebral cortex atrophy.
 
Interactions
E2f5 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell projection organization, G1/S transition of mitotic cell cycle, ...
Component cytoplasm, nuclear envelope, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (191)    Tissues (172)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 146
Western blot 37
RT-PCR 8
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase e2f5 ; ZFIN e2f5    NEW 
Molecular
reagents
All nucleic(67) cDNA(65) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000051204 (Evidence)
Ensembl Gene Model ENSMUSG00000027552 (Evidence)
Entrez Gene 13559 (Evidence)
UniGene 153415
DFCI TC1605389, TC1578494
DoTS DT.492451, DT.87059609
NIA Mouse Gene Index U003038
Consensus CDS Project CCDS38391.1
International Mouse Phenotyping Consortium Status E2f5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051204 VEGA Gene Model | MGI Sequence Detail 27669 C57BL/6J ±  kb
transcript OTTMUST00000129682 VEGA | MGI Sequence Detail 1779 Not Applicable 
polypeptide OTTMUSP00000069634 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015633 E2F Family
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006856 transcription factor E2F5
References
(Earliest) J:31127 Buck V, et al., Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene. 1995 Jul 6;11(1):31-8
(Latest) J:212272 Wu J, et al., Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7
All references(52)
Other
accession IDs
MGD-MRK-32131, MGI:2139902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory