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E2f5 Gene Detail
Summary
  • Symbol
    E2f5
  • Name
    E2F transcription factor 5
  • Synonyms
    E2F-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:105091
    NCBI Gene: 13559
  • Gene Overview
    MyGene.info: E2F5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:14578641-14606309 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 3.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105091
protein coding gene Chr3:14578602-14606309 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027074
protein coding gene Chr3:11705260-11732532 (+)
A/J MGP_AJ_G0027038
protein coding gene Chr3:11696879-11721610 (+)
AKR/J MGP_AKRJ_G0027008
protein coding gene Chr3:11681168-11708505 (+)
BALB/cJ MGP_BALBcJ_G0027047
protein coding gene Chr3:11433575-11458851 (+)
C3H/HeJ MGP_C3HHeJ_G0026787
protein coding gene Chr3:12006866-12036164 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027491
protein coding gene Chr3:12506759-12532805 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024853
protein coding gene Chr3:10026446-10049570 (+)
CAST/EiJ MGP_CASTEiJ_G0026245
protein coding gene Chr3:12003138-12028006 (+)
CBA/J MGP_CBAJ_G0026765
protein coding gene Chr3:12705163-12732578 (+)
DBA/2J MGP_DBA2J_G0026901
protein coding gene Chr3:11266455-11296298 (+)
FVB/NJ MGP_FVBNJ_G0026868
protein coding gene Chr3:11092918-11118266 (+)
LP/J MGP_LPJ_G0027011
protein coding gene Chr3:12282774-12312217 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026889
protein coding gene Chr3:14469783-14495249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027551
protein coding gene Chr3:11496550-11520855 (+)
PWK/PhJ MGP_PWKPhJ_G0025980
protein coding gene Chr3:11381083-11408846 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025783
protein coding gene Chr3:11549152-11572299 (+)
WSB/EiJ MGP_WSBEiJ_G0026316
protein coding gene Chr3:11558314-11585260 (+)



Homology
more
  • Human Ortholog
    E2F5, E2F transcription factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    E2F5, E2F transcription factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E2F-5
  • Links
    NCBI Gene ID: 1875
    neXtProt AC: NX_Q15329
    UniProt: Q15329

  • Chr Location
    8q21.2; chr8:85177384-85214518 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with E2f5 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice develop non-obstructive hydrocephalus, ruffled coats, ataxic gait, and dehydration after weaning and die prematurely at an average age of 6 weeks. They exhibit dilated ventricles and cerebral cortex atrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027552 Ensembl Gene Model | MGI Sequence Detail 27669 C57BL/6J ±  kb
    transcript ENSMUST00000165922 Ensembl | MGI Sequence Detail 1751 Not Applicable  
    polypeptide ENSMUSP00000127877 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR003316 E2F/DP family, winged-helix DNA-binding domain
      IPR037241 E2F-DP heterodimerization region
      IPR015633 E2F Family
      IPR032198 E2F transcription factor, CC-MB domain
      IPR028316 Transcription factor E2F5
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 67
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32131, MGI:2139902
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 11
      Phenotypes 4
    • Earliest
      J:31127 Buck V, et al., Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene. 1995 Jul 6;11(1):31-8
    • Latest
      J:256929 Otto T, et al., Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10660-10665

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory