E2f5
Gene Detail

Symbol Name ID

E2f5 E2F transcription factor 5 MGI:105091

Synonyms

E2F-5

Feature Type

protein coding gene

Genetic Map

Chromosome 3

3.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:14578671-14606308 bp, + strand From Ensembl annotation of GRCm38   27638 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1472  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f5

Human homologs

Human Homolog		E2F5, E2F transcription factor 5, p130-binding
NCBI Gene ID		1875
neXtProt AC		NX_Q15329
Human Synonyms		E2F-5
Human Chr (Location)		8q21.2; chr8:86089619-86126753 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice develop non-obstructive hydrocephalus, ruffled coats, ataxic gait, and dehydration after weaning and die prematurely at an average age of 6 weeks. They exhibit dilated ventricles and cerebral cortex atrophy.

 
Human Diseases Modeled Using Mouse E2f5 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	G1/S transition of mitotic cell cycle, organ morphogenesis, ...
Component	cytoplasm, nuclear envelope, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (198)    Tissues (177)    Images (6)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	146
Western blot	37
RT-PCR	15

cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(67) cDNA(65) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000027552 (Evidence)
Entrez Gene	13559 (Evidence)
UniGene	153415
DFCI	TC1578494, TC1605389
DoTS	DT.492451, DT.87059609
NIA Mouse Gene Index	U003038
Consensus CDS Project	CCDS38391.1
International Mouse Knockout Project Status	E2f5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000027552	Ensembl Gene Model | MGI Sequence Detail	27638	C57BL/6J
transcript	ENSMUST00000165922	Ensembl | MGI Sequence Detail	1751	Not Applicable
polypeptide	ENSMUSP00000127877	Ensembl | MGI Sequence Detail	336	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(94 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015633	E2F Family
InterPro	IPR003316	Transcription factor E2F/dimerisation partner (TDP)
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000006856	transcription factor E2F5

References

(Earliest) J:31127 Buck V, et al., Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene. 1995 Jul 6;11(1):31-8
(Latest) J:190713 Chen HZ, et al., Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov;14(11):1192-202
All references(50)

Other accession IDs

MGD-MRK-32131, MGI:2139902