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E2f5
Gene Detail
Symbol

Name
ID
E2f5
E2F transcription factor 5
MGI:105091
Synonyms
E2F-5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
3.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:14578671-14606309 bp, + strand
From NCBI annotation of GRCm38

  27639 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1472  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor E2F
Gene Tree: E2f5

Human
homologs
Human Homolog E2F5, E2F transcription factor 5, p130-binding
NCBI Gene ID 1875
neXtProt AC  NX_Q15329
Human Synonyms  E2F-5
Human Chr (Location)  8q21.2; chr8:85177384-85214518 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop non-obstructive hydrocephalus, ruffled coats, ataxic gait, and dehydration after weaning and die prematurely at an average age of 6 weeks. They exhibit dilated ventricles and cerebral cortex atrophy.
 
Interactions
E2f5 interacts with 202 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell projection organization, G1/S transition of mitotic cell cycle, ...
Component cytoplasm, nuclear envelope, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (191)    Tissues (172)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 146
Western blot 37
RT-PCR 8
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(65) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000027552 (Evidence)
Entrez Gene13559 (Evidence)
UniGene153415
DFCITC1578494, TC1605389
DoTSDT.87059609, DT.492451
NIA Mouse Gene IndexU003038
Consensus CDS ProjectCCDS38391.1
International Mouse Knockout Project StatusE2f5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13559 NCBI Gene Model | MGI Sequence Detail 27639 C57BL/6J ±  kb
transcript NM_007892 RefSeq | MGI Sequence Detail 1763 Not Specified 
polypeptide Q61502 UniProt | EBI | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015633 E2F Family
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006856 transcription factor E2F5
Graphical View of Protein Domain Structure
References
(Earliest) J:31127 Buck V, et al., Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene. 1995 Jul 6;11(1):31-8
(Latest) J:190713 Chen HZ, et al., Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov;14(11):1192-202
All references(51)
Other
accession IDs
MGD-MRK-32131, MGI:2139902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory