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E2f5 Gene Detail
Summary
  • Symbol
    E2f5
  • Name
    E2F transcription factor 5
  • Synonyms
    E2F-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:105091
    NCBI Gene: 13559
  • Gene Overview
    MyGene.info: E2F5
Location & Maps
more
  • Sequence Map
    Chr3:14578641-14606309 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27669 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 3.10 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    E2F5, E2F transcription factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    E2F5, E2F transcription factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E2F-5
  • Links
    NCBI Gene ID: 1875
    neXtProt AC: NX_Q15329

  • Chr Location
    8q21.2; chr8:85177056-85214518 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop non-obstructive hydrocephalus, ruffled coats, ataxic gait, and dehydration after weaning and die prematurely at an average age of 6 weeks. They exhibit dilated ventricles and cerebral cortex atrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051204 VEGA Gene Model | MGI Sequence Detail 27669 C57BL/6J ±  kb
transcript OTTMUST00000129682 VEGA | MGI Sequence Detail 1779 Not Applicable  
polypeptide OTTMUSP00000069634 VEGA | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 67
    cDNA 65
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-32131, MGI:2139902
References
more
  • Summaries
    All 51
    Developmental Gene Expression 20
    Gene Ontology 9
    Phenotypes 4
  • Earliest
    J:31127 Buck V, et al., Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene. 1995 Jul 6;11(1):31-8
  • Latest
    J:228346 Danielian PS, et al., E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle. 2016 Jan 17;15(2):250-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory