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Hsd17b1
Gene Detail
 Symbol
Name
ID
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
MGI:105077
Synonyms 17beta-HSD, Hsd17ba
Feature Type protein coding gene
Genetic Map
Chromosome 11
64.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:101078411-101080527 bp, + strand
From VEGA annotation of GRCm38

  2117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: estradiol 17beta-dehydrogenase
Gene Tree: Hsd17b1

Human
homologs
Human Homolog HSD17B1, hydroxysteroid (17-beta) dehydrogenase 1
NCBI Gene ID 3292
neXtProt AC  NX_P14061
Human Synonyms  EDH17B2, EDHB17, HSD17, SDR28C1
Human Chr (Location)  17q11-q21; chr17:42548357-42555214 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
Interactions
Hsd17b1 interacts with 76 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process estrogen biosynthetic process, lipid metabolic process, ...
Component cytoplasm, cytosol, ...
Function estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (104)    Tissues (98)   
Theiler Stages: 22, 23, 25, 27, 28
Assay TypeResults
RNA in situ 94
RT-PCR 10
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(15) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002687 (Evidence)
Ensembl Gene ModelENSMUSG00000019301 (Evidence)
Entrez Gene15485 (Evidence)
UniGene188939
DFCITC1586778
DoTSDT.40154594
NIA Mouse Gene IndexU013354
EC1.1.1.62
Consensus CDS ProjectCCDS25445.1
International Mouse Knockout Project StatusHsd17b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002687 VEGA Gene Model | MGI Sequence Detail 2117 C57BL/6J ±  kb
transcript OTTMUST00000005287 VEGA | MGI Sequence Detail 1339 Not Applicable 
polypeptide OTTMUSP00000002510 VEGA | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011348 17beta-dehydrogenase
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008773 estradiol 17-beta-dehydrogenase 1
References (Earliest) J:25103 Deyashiki Y, et al., Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995 May 5;270(18):10461-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(45)
Other
accession IDs
MGD-MRK-24094, MGD-MRK-32117, MGI:700002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory