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Hsd17b1 Gene Detail
Summary
  • Symbol
    Hsd17b1
  • Name
    hydroxysteroid (17-beta) dehydrogenase 1
  • Synonyms
    17beta-HSD, Hsd17ba
  • Feature Type
    protein coding gene
  • IDs
    MGI:105077
    NCBI Gene: 15485
Location & Maps
more
  • Sequence Map
    Chr11:101078411-101080527 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2117 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HSD17B1, hydroxysteroid (17-beta) dehydrogenase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSD17B1, hydroxysteroid (17-beta) dehydrogenase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDH17B2, EDHB17, HSD17, SDR28C1
  • Links
    NCBI Gene ID: 3292
    neXtProt AC: NX_P14061

  • Chr Location
    17q11-q21; chr17:42551943-42555214 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Hsd17b1
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002687 VEGA Gene Model | MGI Sequence Detail 2117 C57BL/6J ±  kb
transcript OTTMUST00000005287 VEGA | MGI Sequence Detail 1339 Not Applicable  
polypeptide OTTMUSP00000002510 VEGA | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    23 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 3
    cDNA 15
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-24094, MGD-MRK-32117, MGI:700002
References
more
  • Summaries
    All 44
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:25103 Deyashiki Y, et al., Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995 May 5;270(18):10461-7
  • Latest
    J:225533 Hakkarainen J, et al., Hydroxysteroid (17beta)-dehydrogenase 1-deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production. FASEB J. 2015 Sep;29(9):3806-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory