About   Help   FAQ
Hsd17b1
Gene Detail
Symbol

Name
ID
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
MGI:105077
Synonyms
17beta-HSD, Hsd17ba
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:101078411-101080527 bp, + strand
From VEGA annotation of GRCm38

  2117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HSD17B1
Protein SuperFamily: estradiol 17beta-dehydrogenase
Gene Tree: Hsd17b1

Human
homologs
HSD17B1, hydroxysteroid (17-beta) dehydrogenase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3292
neXtProt AC: NX_P14061

Human Synonyms: EDH17B2, EDHB17, HSD17, SDR28C1

Human Chr (Location): 17q11-q21; chr17:42551943-42555214 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Hsd17b1 (1)
Incidental mutations (data from APF )
Interactions
Hsd17b1 interacts with 76 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process estrogen biosynthetic process, lipid metabolic process, ...
Component cytoplasm, cytosol, ...
Function estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (104)    Tissues (98)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 10
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hsd17b1    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(15) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002687 (Evidence)
Ensembl Gene Model ENSMUSG00000019301 (Evidence)
Entrez Gene 15485 (Evidence)
UniGene 188939
DFCI TC1586778
DoTS DT.40154594
NIA Mouse Gene Index U013354
EC 1.1.1.62
Consensus CDS Project CCDS25445.1
International Mouse Phenotyping Consortium Status Hsd17b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002687 VEGA Gene Model | MGI Sequence Detail 2117 C57BL/6J ±  kb
transcript OTTMUST00000005287 VEGA | MGI Sequence Detail 1339 Not Applicable 
polypeptide OTTMUSP00000002510 VEGA | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011348 17beta-dehydrogenase
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008773 estradiol 17-beta-dehydrogenase 1
References
(Earliest) J:25103 Deyashiki Y, et al., Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995 May 5;270(18):10461-7
(Latest) J:220472 Zhao L, et al., Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1. Development. 2015 Mar 15;142(6):1083-8
All references(46)
Other
accession IDs
MGD-MRK-24094, MGD-MRK-32117, MGI:700002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory