Was
Gene Detail

Symbol Name ID

Was Wiskott-Aldrich syndrome homolog (human) MGI:105059

Synonyms

U42471, Wasp

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:8081453-8090498 bp, - strand From VEGA annotation of GRCm38   9046 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30970  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: Wasp protein, metazoan type
Gene Tree: Was

Human homologs

Human Homolog		WAS, Wiskott-Aldrich syndrome
NCBI Gene ID		7454
neXtProt AC		NX_P42768
Human Synonyms		IMD2, SCNX, THC, THC1, WASP
Human Chr (Location)		Xp11.4-p11.21; chrX:48542186-48549818 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human WAS

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(3)
 

Homozygous mutant females and hemizygous mutant males exhibit reduced numbers of peripheral blood lymphocytes and platelets, but increased numbers of neutrophils.

 
Human Diseases Modeled Using Mouse Was (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	actin filament-based movement, actin filament organization, ...
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(11)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(3) cDNA(11) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018093 (Evidence)
Ensembl Gene Model	ENSMUSG00000031165 (Evidence)
Entrez Gene	22376 (Evidence)
UniGene	4735
DFCI	TC1583549
DoTS	DT.99839800
Consensus CDS Project	CCDS29984.1
International Mouse Knockout Project Status	Was

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018093	VEGA Gene Model | MGI Sequence Detail	9046	C57BL/6J
transcript	OTTMUST00000043683	VEGA | MGI Sequence Detail	2114	Not Applicable
polypeptide	OTTMUSP00000019623	VEGA | MGI Sequence Detail	520	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000697	EVH1
InterPro	IPR000095	PAK-box/P21-Rho-binding
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR003124	WH2 domain
InterPro	IPR011026	Wiscott-Aldrich syndrome, C-terminal
Protein Ontology	PR:000017371	Wiskott-Aldrich syndrome protein

References

(Earliest) J:13626 Ferguson JM, et al., Stumpy. Mouse News Lett. 1973;49:23
(Latest) J:195436 Schachtner H, et al., Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood. 2013 Mar 28;121(13):2542-52
All references(114)

Other accession IDs

MGD-MRK-32098, MGI:2144716