About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Was
Wiskott-Aldrich syndrome
MGI:105059
59 phenotypes from 5 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Y
involves: BALB/c * C57BL/6 		abnormal B cell physiology J:182528
abnormal renal corpuscle morphology J:182528
decreased B cell number J:182528
decreased follicular B cell number J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgM level J:182528
increased plasma cell number J:182528
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Was+
involves: BALB/c * C57BL/6 		abnormal B cell number J:182528
abnormal B cell proliferation J:182528
Cd79atm1(cre)Reth/Cd79a+
Wastm1.1Ldn/Wastm1.1Ldn
involves: BALB/c * C57BL/6 		abnormal B cell physiology J:182528
abnormal renal corpuscle morphology J:182528
decreased B cell number J:182528
decreased follicular B cell number J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgM level J:182528
increased plasma cell number J:182528
Wastm1Itl/Y
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Itl/Wastm1Itl
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Kas/Wastm1Kas
involves: 129/Sv * C57BL/6 		decreased B cell number J:87875
decreased double-positive T cell number J:87875
decreased lymphocyte cell number J:87875
decreased T cell number J:87875
lymphoid hypoplasia J:87875
thrombocytopenia J:87875
thymus hypoplasia J:87875
Wastm1Sbs/Y
involves: 129S6/SvEvTac 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased monocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Sbs/Y
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell physiology J:182528
abnormal renal corpuscle morphology J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgA level J:182528
increased IgE level J:182528
increased IgM level J:182528
increased plasma cell number J:182528
thrombocytopenia J:182528
Wastm1Sbs/Wastm1Sbs
129S6/SvEvTac-Wastm1Sbs/J 		abnormal glomerular mesangium morphology J:180407
abnormal kidney morphology J:180407
expanded mesangial matrix J:180407
glomerulonephritis J:180407
increased IgA level J:180407
increased IgM level J:180407
increased mesangial cell number J:180407
increased urine protein level J:180407
renal glomerular immunoglobulin deposits J:180407
Wastm1Sbs/Wastm1Sbs
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal crypts of Lieberkuhn morphology J:48836
colitis J:48836
crypts of Lieberkuhn abscesses J:48836
decreased B cell number J:48836
decreased lymphocyte cell number J:48836
decreased T cell number J:48836
decreased T cell proliferation J:48836
normal immune system phenotype J:48836
increased neutrophil cell number J:48836
normal neoplasm J:48836
thrombocytopenia J:48836
Wastm1Sbs/Wastm1Sbs
involves: 129S6/SvEvTac 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal double-negative T cell morphology J:125309
abnormal double-positive T cell morphology J:125309
abnormal lymphocyte morphology J:153247
abnormal thymocyte activation J:125309
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased monocyte cell number J:153247
increased splenocyte number J:153247
spleen hyperplasia J:153247
thrombocytopenia J:153247
Wastm1Sbs/Wastm1Sbs
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell physiology J:182528
abnormal megakaryocyte morphology J:195436
abnormal renal corpuscle morphology J:182528
decreased marginal zone B cell number J:182528
decreased mature B cell number J:182528
increased anti-chromatin antibody level J:182528
increased anti-double stranded DNA antibody level J:182528
increased anti-single stranded DNA antibody level J:182528
increased autoantibody level J:182528
increased germinal center B cell number J:182528
increased IgA level J:182528
increased IgE level J:182528
increased IgM level J:182528
increased plasma cell number J:182528
thrombocytopenia J:182528
Wastm1Sbs/Wastm1Sbs
involves: 129S/SvEv 		abnormal bone marrow cell morphology/development J:84888
abnormal cell migration J:84888
abnormal cytokine secretion J:86835
abnormal mast cell morphology J:86835
abnormal mast cell physiology J:86835
abnormal osteoclast differentiation J:90542
abnormal osteoclast physiology J:90542
Wastm1Sbs/Wastm1Sbs
involves: BALB/c 		abnormal dendritic cell antigen presentation J:84131
decreased T cell proliferation J:84131
normal immune system phenotype J:84131
Wastm1Sbs/Wastm1Sbs
involves: C57BL/6 * CBA 		abnormal B cell physiology J:95909
Wastm2Itl/Y
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
thrombocytopenia J:153247
Wastm2Itl/Wastm2Itl
Not Specified 		abnormal dendritic cell morphology J:153247
abnormal dendritic cell physiology J:153247
abnormal lymphocyte morphology J:153247
decreased NK cell number J:153247
decreased T cell number J:153247
decreased T cell proliferation J:153247
increased anti-double stranded DNA antibody level J:153247
increased B cell number J:153247
increased follicular B cell number J:153247
increased leukocyte cell number J:153247
increased splenocyte number J:153247
thrombocytopenia J:153247
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory