Phenotypes for Was MGI:5307127 MGI Mouse

homeostasis/metabolism

increased urine protein level ( J:180407 )

• mutants older than 6 months of age exhibit proteinuria

immune system

increased IgA level ( J:180407 )

• elevation in serum IgA, both in young and old mutants

• B cells exhibit increased IgA production after stimulation with LPS, TGF-beta1, IL-4, and IL-5

• reduced ratio of sialylated and galactosylated IgA in the serum, indicating that glycosylation of IgA is abnormal in mutants

• mutants exhibit higher titers of circulating IgA-containing complexes

• mutants exhibit increased glomerular IgA deposition in the kidneys

increased IgM level ( J:180407 )

• mutants exhibit increased glomerular IgM and C3 complement deposition in the kidneys

glomerulonephritis ( J:180407 )

• mutants develop proliferative glomerulonephritis similar to human IgA nephropathy

renal/urinary system

increased urine protein level ( J:180407 )

• mutants older than 6 months of age exhibit proteinuria

abnormal kidney morphology ( J:180407 )

• mutants exhibit renal injury with increasing severity with advancing age

glomerulonephritis ( J:180407 )

• mutants develop proliferative glomerulonephritis similar to human IgA nephropathy

• mutants older than 6 months of age exhibit hump-like mesangial and paramesangial deposits

increased mesangial cell number ( J:180407 )

• mutants older than 6 months of age, exhibit increased mesangial cellularity with or without endocapillary proliferation

expanded mesangial matrix ( J:180407 )

• mutants older than 6 months of age, exhibit increased matrix deposition with or without endocapillary proliferation

• increased glomerular IgA deposition

hematopoietic system