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Was
Gene Detail
 Symbol
Name
ID
Was
Wiskott-Aldrich syndrome homolog (human)
MGI:105059
Synonyms U42471, Wasp
Feature Type protein coding gene
Genetic Map
Chromosome X
3.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:8081453-8090498 bp, - strand
From VEGA annotation of GRCm38

  9046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30970  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: Wasp protein, metazoan type
Gene Tree: Was

Human
homologs
Human Homolog WAS, Wiskott-Aldrich syndrome
NCBI Gene ID 7454
neXtProt AC  NX_P42768
Human Synonyms  IMD2, SCNX, THC, THC1, WASP
Human Chr (Location)  Xp11.4-p11.21; chrX:48683797-48691427 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human WAS
Alleles
and
phenotypes
All alleles(10) : Targeted(7) Gene trapped(3)
 
Homozygous mutant females and hemizygous mutant males exhibit reduced numbers of peripheral blood lymphocytes and platelets, but increased numbers of neutrophils.
 
Human Diseases Modeled Using Mouse Was (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process actin filament-based movement, actin filament organization, ...
Component cell, cell-cell junction, ...
Function actin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(11)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(3) cDNA(11) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018093 (Evidence)
Ensembl Gene ModelENSMUSG00000031165 (Evidence)
Entrez Gene22376 (Evidence)
UniGene4735
DFCITC1583549
DoTSDT.99839800
Consensus CDS ProjectCCDS29984.1
International Mouse Knockout Project StatusWas
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018093 VEGA Gene Model | MGI Sequence Detail 9046 C57BL/6J ±  kb
transcript OTTMUST00000043683 VEGA | MGI Sequence Detail 2114 Not Applicable 
polypeptide OTTMUSP00000019623 VEGA | MGI Sequence Detail 520 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000697 EVH1
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR003124 WH2 domain
InterPro IPR011026 Wiscott-Aldrich syndrome, C-terminal
Protein Ontology PR:000017371 Wiskott-Aldrich syndrome protein
References (Earliest) J:13626 Ferguson JM, et al., Stumpy. Mouse News Lett. 1973;49:23
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(120)
Other
accession IDs
MGD-MRK-32098, MGI:2144716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory