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Was Gene Detail
Summary
  • Symbol
    Was
  • Name
    Wiskott-Aldrich syndrome
  • Synonyms
    U42471, Wasp
  • Feature Type
    protein coding gene
  • IDs
    MGI:105059
    NCBI Gene: 22376
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:8081466-8090491 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105059
protein coding gene ChrX:8081453-8090498 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035539
protein coding gene ChrX:2721312-2732210 (-)
A/J MGP_AJ_G0035516
protein coding gene ChrX:2703578-2711879 (-)
AKR/J MGP_AKRJ_G0035449
protein coding gene ChrX:2803797-2813203 (-)
BALB/cJ MGP_BALBcJ_G0035513
protein coding gene ChrX:2697967-2707035 (-)
C3H/HeJ MGP_C3HHeJ_G0035221
protein coding gene ChrX:2772280-2782591 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036037
protein coding gene ChrX:2808414-2819058 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032912
protein coding gene ChrX:2228024-2236511 (-)
CAST/EiJ MGP_CASTEiJ_G0034522
protein coding gene ChrX:2664668-2673611 (-)
CBA/J MGP_CBAJ_G0035191
protein coding gene ChrX:2961958-2972927 (-)
DBA/2J MGP_DBA2J_G0035348
protein coding gene ChrX:2689750-2698526 (-)
FVB/NJ MGP_FVBNJ_G0035295
protein coding gene ChrX:2654014-2662690 (-)
LP/J MGP_LPJ_G0035425
protein coding gene ChrX:2739347-2747873 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035335
protein coding gene ChrX:2915900-2927077 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036055
protein coding gene ChrX:2705759-2714469 (-)
PWK/PhJ MGP_PWKPhJ_G0034222
protein coding gene ChrX:2625455-2635045 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034061
protein coding gene ChrX:2684053-2696058 (-)
WSB/EiJ MGP_WSBEiJ_G0034645
protein coding gene ChrX:2710597-2721335 (-)



Homology
more
  • Human Ortholog
    WAS, Wiskott-Aldrich syndrome
  • Vertebrate Orthologs
    6
  • Human Ortholog
    WAS, Wiskott-Aldrich syndrome
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD2, SCNX, THC, THC1, WASP, WASPA
  • Links
    NCBI Gene ID: 7454
    neXtProt AC: NX_P42768
    UniProt: P42768

  • Chr Location
    Xp11.23; chrX:48683753-48691427 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Was mouse models; 3 with human WAS associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 5 alleles in 10 genetic backgrounds
    11 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant females and hemizygous mutant males exhibit reduced numbers of peripheral blood lymphocytes and platelets, but increased numbers of neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22376 NCBI Gene Model | MGI Sequence Detail 9026 C57BL/6J ±  kb
    transcript NM_009515 RefSeq | MGI Sequence Detail 2094 C57BL/6  
    polypeptide P70315 UniProt | EBI | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 3
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32098, MGI:2144716
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 13
      Phenotypes 86
    • Earliest
      J:29221 Derry JM, et al., The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome. Genomics. 1995 Sep 20;29(2):471-7
    • Latest
      J:262847 Biswas A, et al., WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 May 3;9(1):1779

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory