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Ddx6 Gene Detail
Summary
  • Symbol
    Ddx6
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
  • Synonyms
    1110001P04Rik, C430015D01Rik, E230023J21Rik, HLR2, mRCK/P54, p54, rck
  • Feature Type
    protein coding gene
  • IDs
    MGI:104976
    NCBI Gene: 13209
  • Gene Overview
    MyGene.info: DDX6
Location & Maps
more
  • Sequence Map
    Chr9:44604892-44640731 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35840 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    DDX6, DEAD-box helicase 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX6, DEAD-box helicase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HLR2, P54, RCK
  • Links
    NCBI Gene ID: 1656
    neXtProt AC: NX_P26196

  • Chr Location
    11q23.3; chr11:118747763-118791263 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032097 Ensembl Gene Model | MGI Sequence Detail 35840 C57BL/6J ±  kb
transcript ENSMUST00000170489 Ensembl | MGI Sequence Detail 6065 Not Applicable  
polypeptide ENSMUSP00000128421 Ensembl | MGI Sequence Detail 483 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    235 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000029398 ATP-dependent RNA helicase DDX6
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 139
    Genomic 10
    cDNA 123
    Primer pair 5
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-31049, MGI:1923546, MGI:1925955, MGI:2444175
References
more
  • Summaries
    All 52
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:30308 Seto M, et al., Cloning and expression of a murine cDNA homologous to the human RCK/P54, a lymphoma-linked chromosomal translocation junction gene on 11q23. Gene. 1995 Dec 12;166(2):293-6
  • Latest
    J:217461 Yang G, et al., An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014 Nov 19;84(4):723-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory