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Ddx6
Gene Detail
Symbol

Name
ID
Ddx6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
MGI:104976
Synonyms
1110001P04Rik, C430015D01Rik, E230023J21Rik, HLR2, mRCK/P54, p54, rck
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:44604892-44640731 bp, + strand
From Ensembl annotation of GRCm38

  35840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ATP-dependent RNA helicase DHH1
Gene Tree: Ddx6

Human
homologs
Human Homolog   DDX6, DEAD (Asp-Glu-Ala-Asp) box helicase 6
NCBI Gene ID 1656
neXtProt AC  NX_P26196
Human Synonyms  HLR2, P54, RCK
Human Chr (Location)  11q23.3; chr11:118747763-118791263 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(100) : Gene trapped(98) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ddx6 interacts with 481 markers (Mir1a-2, Mir1b, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cytoplasmic mRNA processing body assembly, negative regulation of neuron differentiation, ...
Component cytoplasm, cytoplasmic mRNA processing body, ...
Function ATP binding, helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (42)    Tissues (9)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
Northern blot 6
RT-PCR 16
cDNA source data(121)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) Genomic(10) cDNA(123) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000032097 (Evidence)
Entrez Gene13209
UniGene267061
DFCITC1609037, TC1579438, TC1631917, TC1686126, TC1651300
DoTSDT.534646, DT.87050229, DT.97365528, DT.91330726
NIA Mouse Gene IndexU052832, U010398, U010397
EC3.6.4.13
Consensus CDS ProjectCCDS23116.1
International Mouse Knockout Project StatusDdx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032097 Ensembl Gene Model | MGI Sequence Detail 35840 C57BL/6J ±  kb
transcript ENSMUST00000170489 Ensembl | MGI Sequence Detail 6065 Not Applicable 
polypeptide ENSMUSP00000128421 Ensembl | MGI Sequence Detail 483 Not Applicable 

For the selected sequences
All sequences(26) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000629 RNA helicase, ATP-dependent, DEAD-box, conserved site
InterPro IPR014014 RNA helicase, DEAD-box type, Q motif
Protein Ontology PR:000029398 ATP-dependent RNA helicase DDX6
References
(Earliest) J:30308 Seto M, et al., Cloning and expression of a murine cDNA homologous to the human RCK/P54, a lymphoma-linked chromosomal translocation junction gene on 11q23. Gene. 1995 Dec 12;166(2):293-6
(Latest) J:217461 Yang G, et al., An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014 Nov 19;84(4):723-39
All references(54)
Other
accession IDs
MGD-MRK-31049, MGI:1923546, MGI:1925955, MGI:2444175

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory