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Ddx6 Gene Detail
Summary
  • Symbol
    Ddx6
  • Name
    DEAD-box helicase 6
  • Synonyms
    1110001P04Rik, C430015D01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, E230023J21Rik, HLR2, mRCK/P54, p54, rck
  • Feature Type
    protein coding gene
  • IDs
    MGI:104976
    NCBI Gene: 13209
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44516189-44552028 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    772 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104976
 protein coding gene Chr9:44514113-44552028 (+)
129S1/SvImJ ENSMUSG00200018369
 protein coding gene Chr9:41592682-41628837 (+)
A/J ENSMUSG00195023501
 protein coding gene Chr9:41345949-41382493 (+)
AKR/J ENSMUSG00220038811
 protein coding gene Chr9:41432703-41468566 (+)
BALB/cJ ENSMUSG00180022213
 protein coding gene Chr9:41457674-41494218 (+)
C3H/HeJ ENSMUSG00175012963
 protein coding gene Chr9:41469355-41506117 (+)
C57BL/6NJ ENSMUSG00215034901
 protein coding gene Chr9:41436487-41472330 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032122
 protein coding gene Chr9:41478159-41511922 (+)
CAST/EiJ ENSTCUG00005015112
 protein coding gene Chr9:41422277-41457982 (+)
CBA/J ENSMUSG00210016577
 protein coding gene Chr9:41515914-41551731 (+)
DBA/2J ENSMUSG00185009828
 protein coding gene Chr9:41584274-41620811 (+)
FVB/NJ ENSMUSG00205034566
 protein coding gene Chr9:41832153-41868013 (+)
JF1/MsJ ENSUMUG00000016047
 protein coding gene Chr9:41632381-41668537 (+)
LP/J ENSMUSG00230036277
 protein coding gene Chr9:41883146-41919296 (+)
NOD/ShiLtJ ENSMUSG00190020861
 protein coding gene Chr9:41663244-41699780 (+)
NZO/HlLtJ ENSMUSG00225041536
 protein coding gene Chr9:41844096-41879912 (+)
PWK/PhJ ENSLUMG00010018602
 protein coding gene Chr9:41592633-41628542 (+)
SPRET/EiJ ENSMSPG00010008852
 protein coding gene Chr9:42356406-42385353 (+)
WSB/EiJ ENSIUOG00005019208
 protein coding gene Chr9:41077181-41113007 (+)



Homology
more
  • Human Ortholog
    DDX6, DEAD-box helicase 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX6, DEAD-box helicase 6
  • Synonyms
    HLR2, IDDILF, P54, RCK, Rck/p54
  • Links
    NCBI Gene ID: 1656
    UniProt: P26196

  • Chr Location
    11q23.3; chr11:118747763-118791744 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit lethality prior to E11.5, decreased embryo size, embryonic growth retardation, caudal body truncation, and delayed primitive streak formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    678
  • Tissues
    28
  • cDNA Data
    122
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032097 Ensembl Gene Model | MGI Sequence Detail 35840 C57BL/6J ±  kb
    transcript ENSMUST00000170489 Ensembl | MGI Sequence Detail 6065 Not Applicable  
    polypeptide ENSMUSP00000128421 Ensembl | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000029398 probable ATP-dependent RNA helicase DDX6
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR011545 DEAD/DEAH-box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    • GlyGen
      P54823 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 143
      Genomic 10
      cDNA 124
      Primer pair 6
      Other 3
      Antibodies 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-31049, MGI:1923546, MGI:1925955, MGI:2444175
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 21
      Gene Ontology 14
      Phenotypes 18
    • Earliest
      J:28620 Akao Y, et al., The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues. Cancer Res. 1995 Aug 1;55(15):3444-9
    • Latest
      J:386593 Lu Y, et al., DDX6 interacts with DDX3X to repress translation in microRNA-mediated silencing. Nucleic Acids Res. 2025 Sep 5;53(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory