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Ddx6 Gene Detail
Summary
  • Symbol
    Ddx6
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
  • Synonyms
    1110001P04Rik, C430015D01Rik, E230023J21Rik, HLR2, mRCK/P54, p54, rck
  • Feature Type
    protein coding gene
  • IDs
    MGI:104976
    NCBI Gene: 13209
  • Gene Overview
    MyGene.info: DDX6
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44604892-44640731 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104976
protein coding gene Chr9:44603817-44640731 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034714
protein coding gene Chr9:43113748-43154555 (+)
A/J MGP_AJ_G0034695
protein coding gene Chr9:41901568-41937510 (+)
AKR/J MGP_AKRJ_G0034622
protein coding gene Chr9:42781771-42816513 (+)
BALB/cJ MGP_BALBcJ_G0034686
protein coding gene Chr9:41649236-41685368 (+)
C3H/HeJ MGP_C3HHeJ_G0034397
protein coding gene Chr9:43225312-43264014 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035207
protein coding gene Chr9:44386024-44419678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032122
protein coding gene Chr9:41478159-41511922 (+)
CAST/EiJ MGP_CASTEiJ_G0033719
protein coding gene Chr9:43080691-43122102 (+)
CBA/J MGP_CBAJ_G0034369
protein coding gene Chr9:46008609-46047228 (+)
DBA/2J MGP_DBA2J_G0034528
protein coding gene Chr9:41805562-41840752 (+)
FVB/NJ MGP_FVBNJ_G0034469
protein coding gene Chr9:41068202-41106794 (+)
LP/J MGP_LPJ_G0034609
protein coding gene Chr9:43412809-43446916 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034513
protein coding gene Chr9:47844174-47887477 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035228
protein coding gene Chr9:42688949-42725081 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0033259
protein coding gene Chr9:42999118-43033150 (+)
WSB/EiJ MGP_WSBEiJ_G0033832
protein coding gene Chr9:42715729-42751118 (+)



Homology
more
  • Human Ortholog
    DDX6, DEAD-box helicase 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX6, DEAD-box helicase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HLR2, P54, RCK
  • Links
    NCBI Gene ID: 1656
    neXtProt AC: NX_P26196
    UniProt: P26196

  • Chr Location
    11q23.3; chr11:118747763-118791263 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032097 Ensembl Gene Model | MGI Sequence Detail 35840 C57BL/6J ±  kb
transcript ENSMUST00000217034 Ensembl | MGI Sequence Detail 6029 Not Applicable  
polypeptide ENSMUSP00000149620 Ensembl | MGI Sequence Detail 483 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 140
    Genomic 10
    cDNA 124
    Primer pair 5
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-31049, MGI:1923546, MGI:1925955, MGI:2444175
References
more
  • Summaries
    All 55
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:30308 Seto M, et al., Cloning and expression of a murine cDNA homologous to the human RCK/P54, a lymphoma-linked chromosomal translocation junction gene on 11q23. Gene. 1995 Dec 12;166(2):293-6
  • Latest
    J:264953 Nicklas S, et al., The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs. Nucleic Acids Res. 2015 Mar 11;43(5):2638-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory