Gene Expression Literature Summary

• Symbol: Ddx6
• Name: DEAD-box helicase 6
• ID: MGI:104976

20 matching records from 20 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E6.5	E7.5	E8.5	E9.5	E10.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)				1	1	1			2	1	1	1	2	2	3		4
In situ RNA (section)											1				1
Immunohistochemistry (whole mount)		1
In situ RNA (whole mount)					1	1		1
Northern blot	1	1															1
Western blot							1	2			1					1	3
RT-PCR			1									1		1			2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ddx6  DEAD-box helicase 6   (Synonyms: 1110001P04Rik, C430015D01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, E230023J21Rik, HLR2, mRCK/P54, p54, rck)
Results	Reference
1	J:155865 Aravin AA, van der Heijden GW, Castaneda J, Vagin VV, Hannon GJ, Bortvin A, Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 2009 Dec;5(12):e1000764
1	J:324707 Dhandapani L, Salzer MC, Duran JM, Zaffagnini G, De Guirior C, Martinez-Zamora MA, Boke E, Comparative analysis of vertebrates reveals that mouse primordial oocytes do not contain a Balbiani body. J Cell Sci. 2022 Dec 1;135(1):jcs259394
1	J:343469 Ding Y, He Z, Sha Y, Kee K, Li L, Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility. Development. 2023 Dec 1;150(23):dev202151
1	J:282329 Hildebrandt MR, Wang Y, Li L, Yasmin L, Glubrecht DD, Godbout R, Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout. Dev Biol. 2019 Nov 15;455(2):420-433
2*	J:305571 Ibayashi M, Aizawa R, Tsukamoto S, mRNA decapping factor Dcp1a is essential for embryonic growth in mice. Biochem Biophys Res Commun. 2021 May 28;555:128-133
4	J:282136 Kato Y, Iwamori T, Ninomiya Y, Kohda T, Miyashita J, Sato M, Saga Y, ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles. EMBO Rep. 2019 Dec 5;20(12):e48251
3	J:329565 Kim J, Muraoka M, Okada H, Toyoda A, Ajima R, Saga Y, The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing. PLoS Genet. 2022 Oct;18(10):e1009967
1*	J:321979 Kurz J, Weiss AC, Thiesler H, Qasrawi F, Deuper L, Kaur J, Rudat C, Ludtke TH, Wojahn I, Hildebrandt H, Trowe MO, Kispert A, Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735
2	J:169836 Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL, Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6
1*	J:103128 Machka C, Kersten M, Zobawa M, Harder A, Horsch M, Halder T, Lottspeich F, Hrabe de Angelis M, Beckers J, Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns. 2005 Dec;6(1):94-101
4	J:264953 Nicklas S, Okawa S, Hillje AL, Gonzalez-Cano L, Del Sol A, Schwamborn JC, The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs. Nucleic Acids Res. 2015 Mar 11;43(5):2638-54
5*	J:51694 Paynton BV, RNA-binding proteins in mouse oocytes and embryos: expression of genes encoding Y box, DEAD box RNA helicase, and polyA binding proteins. Dev Genet. 1998;23(4):285-98
3	J:156018 Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S, The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009 Dec;17(6):775-87
4	J:157579 Suzuki A, Igarashi K, Aisaki K, Kanno J, Saga Y, NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3594-9
1	J:217384 Suzuki A, Niimi Y, Saga Y, Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells. Biol Open. 2014;3(12):1207-16
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1*	J:342865 Wan Y, Yang S, Li T, Cai Y, Wu X, Zhang M, Muhammad T, Huang T, Lv Y, Chan WY, Lu G, Li J, Sha QQ, Chen ZJ, Liu H, LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Res. 2023 Nov 27;51(21):11652-11667
2	J:345099 Wang X, Zhang Y, Yu J, Ma Y, Xu Y, Shi J, Qi Z, Liu X, Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
1	J:169934 Watanabe T, Chuma S, Yamamoto Y, Kuramochi-Miyagawa S, Totoki Y, Toyoda A, Hoki Y, Fujiyama A, Shibata T, Sado T, Noce T, Nakano T, Nakatsuji N, Lin H, Sasaki H, MITOPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline. Dev Cell. 2011 Mar 15;20(3):364-75
1	J:279388 Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Ludtke TH, Kleppa MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO, Kispert A, Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019 Aug;248(4):452-463